iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-115380

Ensembl Protein ID

ENSSSCP00000011578.2

UniProt Accession

Q0MS45; PSN2_PIG

Genbank Protein ID

ABI15722.1; ABX84376.1

Protein Name

Presenilin-2; Presenilin-2 NTF subunit; Presenilin-2 CTF subunit

Genbank Nucleotide ID

DQ853415; EU287432

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000010860.2	ENSSSCT00000011882.2	ENSSSCP00000011578.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	3.80e-08	33.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Sus scrofa

Functional Description
(View)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity).

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTPRS CQEGRQGLED GESAAQWRSQ DSEEDHEEDP 60
DRYVCSGVPG RPPGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCACTT TCATGGCCTC TGACAGCGAG GAAGAAGTGT GTGACGAGCG GACGTCCCTG 60
ATGTCGGCCG AGAGCCCCAC GCCTCGCTCC TGCCAGGAAG GCAGGCAGGG CCTGGAGGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

ssc:780410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	89.96	0.00e+00	635.00
IUUC-Apl-003959	Anas platyrhynchos	77.20	2.00e-163	568.00
IUUC-Aca-005160	Anolis carolinensis	75.91	3.00e-159	554.00
IUUC-Ang-009768	Aspergillus niger	48.15	5.90e-01	29.30
IUUC-Ame-010686	Astyanax mexicanus	79.43	6.00e-147	513.00
IUUC-Bta-013097	Bos taurus	97.77	0.00e+00	736.00
IUUC-Cja-018824	Callithrix jacchus	95.98	0.00e+00	739.00
IUUC-Cfa-020253	Canis familiaris	96.88	0.00e+00	751.00
IUUC-Cpo-021401	Cavia porcellus	96.21	0.00e+00	744.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	9.00e-30	124.00
IUUC-Csa-023369	Chlorocebus sabaeus	97.77	0.00e+00	761.00
IUUC-Dre-028526	Danio rerio	70.56	1.00e-144	505.00
IUUC-Dor-031127	Dipodomys ordii	92.19	0.00e+00	693.00
IUUC-Ete-033081	Echinops telfairi	84.40	1.00e-94	339.00
IUUC-Eca-034387	Equus caballus	97.10	0.00e+00	706.00
IUUC-Eeu-034846	Erinaceus europaeus	82.35	2.00e-151	528.00
IUUC-Fca-035396	Felis catus	95.97	0.00e+00	762.00
IUUC-Fal-037457	Ficedula albicollis	76.96	3.00e-162	564.00
IUUC-Gga-040706	Gallus gallus	77.14	3.00e-158	551.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.24	5.00e-130	457.00
IUUC-Ggo-045338	Gorilla gorilla	97.99	0.00e+00	761.00
IUUC-Hsa-046455	Homo sapiens	97.99	0.00e+00	761.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	97.77	0.00e+00	759.00
IUUC-Lch-049638	Latimeria chalumnae	68.74	2.00e-145	508.00
IUUC-Loc-052427	Lepisosteus oculatus	75.06	3.00e-157	547.00
IUUC-Laf-053758	Loxodonta africana	90.47	0.00e+00	732.00
IUUC-Mcc-054755	Macaca mulatta	97.99	0.00e+00	760.00
IUUC-Mmr-060890	Microcebus murinus	96.43	0.00e+00	745.00
IUUC-Mdo-062197	Monodelphis domestica	81.26	6.00e-179	619.00
IUUC-Mmu-063823	Mus musculus	95.98	0.00e+00	748.00
IUUC-Mac-064858	Musa acuminata	43.86	7.00e-23	100.00
IUUC-Mpu-066181	Mustela putorius furo	96.88	0.00e+00	752.00
IUUC-Nle-069596	Nomascus leucogenys	97.72	0.00e+00	711.00
IUUC-Opr-070344	Ochotona princeps	95.31	0.00e+00	757.00
IUUC-Ont-071867	Oreochromis niloticus	70.79	9.00e-133	466.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.94	2.00e-155	541.00
IUUC-Ocu-074652	Oryctolagus cuniculus	95.76	0.00e+00	710.00
IUUC-Obr-076302	Oryza brachyantha	36.96	8.00e-17	81.60
IUUC-Ola-086707	Oryzias latipes	71.05	9.00e-106	375.00
IUUC-Oga-088560	Otolemur garnettii	96.23	0.00e+00	709.00
IUUC-Oar-089200	Ovis aries	96.88	0.00e+00	711.00
IUUC-Ptr-090569	Pan troglodytes	97.77	0.00e+00	759.00
IUUC-Pan-091742	Papio anubis	97.99	0.00e+00	761.00
IUUC-Psi-093297	Pelodiscus sinensis	77.19	5.00e-133	466.00
IUUC-Pma-094612	Petromyzon marinus	77.57	9.00e-128	449.00
IUUC-Ppa-095431	Physcomitrella patens	31.40	2.00e-27	116.00
IUUC-Pab-098531	Pongo abelii	97.77	0.00e+00	761.00
IUUC-Pca-101120	Procavia capensis	93.53	0.00e+00	720.00
IUUC-Pva-102934	Pteropus vampyrus	87.95	0.00e+00	710.00
IUUC-Rno-106052	Rattus norvegicus	94.42	0.00e+00	753.00
IUUC-Sha-106876	Sarcophilus harrisii	80.30	6.00e-177	613.00
IUUC-Tgu-117280	Taeniopygia guttata	77.83	2.00e-163	568.00
IUUC-Tbe-127632	Tupaia belangeri	96.76	0.00e+00	632.00
IUUC-Ttr-129008	Tursiops truncatus	96.65	0.00e+00	748.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence