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Tag Content
UUCD2 ID IUUC-Oga-088219
UUCD1 version UUC-OtG-00113
Ensembl Protein ID ENSOGAP00000000987.2
UniProt Accession H0WHW5; H0WHW5_OTOGA
Genbank Protein ID ENSOGAP00000000987
Protein Name Platelet-activating factor acetylhydrolase IB subunit alpha; Lissencephaly-1 protein; PAF acetylhydrolase 45 kDa subunit; PAF-AH alpha
Genbank Nucleotide ID AAQR03150306
Gene Name PAFAH1B1; LIS1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSOGAG00000001110.2 ENSOGAT00000001111.2 ENSOGAP00000000987.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.30e-60 196.9 190 229
UBD/Beta-Prp 6.90e-95 317.7 107 410
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH   v+++a  ++ +++vs+s+D+tik+W++ tg ++k+
   Q: 190  GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVQTGYCVKT 229
           899*******99777********************99875 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd++++ 
   Q: 283  SWAPESsyssiseatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372  CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           *****************.99*****************985 PP
   
Organism Otolemur garnettii
Functional Description
(View)

Functional Description


     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
 Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.
Protein Sequence
(Fasta)
ELLNKISSKQ KNRAIADYLR SNGYEEAYSV FKKEAELDMN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Oga-088219|E3,WD_repeat;UBD,Beta-Prp|Otolemur garnettii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCTTTTAA ATAAAATATC TTCAAAACAG AAATGAGATT TTTTTTAAGA GTCATTTGAA 60
TTTTTTTTTC TTTCAGAAAT CGAGCTATAG CAGATTATCT TCGTTCAAAT GGCTATGAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Oga-088219|E3,WD_repeat;UBD,Beta-Prp|Otolemur garnettii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08513--LisH
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00667--LisH
SM00320--WD40
Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0031965--C:nuclear membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0007268--P:chemical synaptic transmission
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0016042--P:lipid catabolic process
GO:0051661--P:maintenance of centrosome location
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0007405--P:neuroblast proliferation
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0036035--P:osteoclast development
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0008090--P:retrograde axonal transport
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 99.75 0.00e+00 835.00
IUUC-Apl-004024 Anas platyrhynchos 96.58 0.00e+00 830.00
IUUC-Aca-004564 Anolis carolinensis 96.33 0.00e+00 824.00
IUUC-Ago-007862 Ashbya gossypii 26.70 1.00e-35 144.00
IUUC-Acl-008360 Aspergillus clavatus 45.68 1.00e-102 367.00
IUUC-Afl-008502 Aspergillus flavus 45.69 1.00e-94 339.00
IUUC-Afu-008848 Aspergillus fumigatus 46.34 1.00e-104 373.00
IUUC-Ani-009173 Aspergillus nidulans 41.94 4.00e-89 321.00
IUUC-Ang-009873 Aspergillus niger 43.69 1.00e-92 333.00
IUUC-Aor-009973 Aspergillus oryzae 43.18 7.00e-90 323.00
IUUC-Ate-010523 Aspergillus terreus 40.95 9.00e-89 320.00
IUUC-Ame-010969 Astyanax mexicanus 92.67 0.00e+00 802.00
IUUC-Bgr-011972 Blumeria graminis 46.43 1.00e-102 366.00
IUUC-Bta-013106 Bos taurus 97.80 0.00e+00 837.00
IUUC-Bci-013615 Botrytis cinerea 43.41 4.00e-96 345.00
IUUC-Cel-018459 Caenorhabditis elegans 56.97 3.00e-145 507.00
IUUC-Cja-018755 Callithrix jacchus 98.04 0.00e+00 838.00
IUUC-Cfa-020749 Canis familiaris 97.80 0.00e+00 837.00
IUUC-Cpo-022371 Cavia porcellus 97.80 0.00e+00 837.00
IUUC-Cre-022578 Chlamydomonas reinhardtii 35.44 5.00e-50 191.00
IUUC-Csa-023524 Chlorocebus sabaeus 99.42 0.00e+00 722.00
IUUC-Cho-024764 Choloepus hoffmanni 89.22 0.00e+00 680.00
IUUC-Cin-025753 Ciona intestinalis 69.44 3.00e-175 607.00
IUUC-Csv-025817 Ciona savignyi 67.89 5.00e-178 617.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 45.75 2.00e-95 342.00
IUUC-Cne-027087 Cryptococcus neoformans 50.39 2.00e-110 392.00
IUUC-Dre-027554 Danio rerio 92.42 0.00e+00 795.00
IUUC-Dno-029050 Dasypus novemcinctus 97.56 0.00e+00 836.00
IUUC-Dor-030222 Dipodomys ordii 89.49 0.00e+00 753.00
IUUC-Dse-031164 Dothistroma septosporum 42.86 1.00e-99 356.00
IUUC-Dme-031745 Drosophila melanogaster 68.05 1.00e-166 578.00
IUUC-Ete-032508 Echinops telfairi 99.64 5.00e-169 587.00
IUUC-Eca-034288 Equus caballus 99.50 0.00e+00 831.00
IUUC-Eeu-034984 Erinaceus europaeus 89.24 0.00e+00 749.00
IUUC-Fca-036498 Felis catus 97.80 0.00e+00 837.00
IUUC-Fal-036920 Ficedula albicollis 96.58 0.00e+00 830.00
IUUC-Fox-037996 Fusarium oxysporum 45.45 6.00e-102 364.00
IUUC-Fso-038160 Fusarium solani 43.26 1.00e-96 346.00
IUUC-Gmo-038983 Gadus morhua 91.69 0.00e+00 790.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.99 2.00e-96 345.00
IUUC-Gga-040623 Gallus gallus 96.58 0.00e+00 830.00
IUUC-Gac-041613 Gasterosteus aculeatus 90.71 0.00e+00 787.00
IUUC-Ggo-045410 Gorilla gorilla 89.22 0.00e+00 726.00
IUUC-Hsa-046358 Homo sapiens 97.56 0.00e+00 834.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 97.80 0.00e+00 837.00
IUUC-Kpa-049351 Komagataella pastoris 28.84 2.00e-41 163.00
IUUC-Lch-049936 Latimeria chalumnae 94.62 0.00e+00 812.00
IUUC-Loc-052476 Lepisosteus oculatus 95.99 0.00e+00 805.00
IUUC-Lma-053170 Leptosphaeria maculans 48.42 4.00e-99 355.00
IUUC-Laf-053713 Loxodonta africana 97.56 0.00e+00 835.00
IUUC-Mcc-054628 Macaca mulatta 97.31 0.00e+00 833.00
IUUC-Meu-055927 Macropus eugenii 86.28 2.00e-140 491.00
IUUC-Mor-056962 Magnaporthe oryzae 44.12 1.00e-95 343.00
IUUC-Mpo-057583 Magnaporthe poae 46.15 3.00e-92 332.00
IUUC-Mla-058819 Melampsora laricipopulina 47.54 1.00e-115 410.00
IUUC-Mga-059945 Meleagris gallopavo 96.33 0.00e+00 829.00
IUUC-Mvi-060403 Microbotryum violaceum 48.66 8.00e-125 440.00
IUUC-Mmr-061289 Microcebus murinus 99.75 0.00e+00 835.00
IUUC-Mdo-061912 Monodelphis domestica 97.07 0.00e+00 829.00
IUUC-Mmu-063253 Mus musculus 97.80 0.00e+00 837.00
IUUC-Mpu-066638 Mustela putorius furo 97.80 0.00e+00 837.00
IUUC-Mlu-067267 Myotis lucifugus 99.50 0.00e+00 834.00
IUUC-Nfi-068571 Neosartorya fischeri 44.72 8.00e-97 347.00
IUUC-Ncr-068895 Neurospora crassa 50.13 1.00e-103 369.00
IUUC-Nle-069087 Nomascus leucogenys 97.01 0.00e+00 677.00
IUUC-Opr-070579 Ochotona princeps 97.56 0.00e+00 836.00
IUUC-Ont-072432 Oreochromis niloticus 92.42 0.00e+00 801.00
IUUC-Oan-073072 Ornithorhynchus anatinus 97.80 0.00e+00 837.00
IUUC-Ocu-074180 Oryctolagus cuniculus 97.56 0.00e+00 836.00
IUUC-Ola-086772 Oryzias latipes 91.93 0.00e+00 792.00
IUUC-Oar-090394 Ovis aries 97.80 0.00e+00 837.00
IUUC-Ptr-091517 Pan troglodytes 97.80 0.00e+00 837.00
IUUC-Pan-092421 Papio anubis 97.31 0.00e+00 833.00
IUUC-Psi-093370 Pelodiscus sinensis 96.82 0.00e+00 831.00
IUUC-Pma-094319 Petromyzon marinus 88.83 0.00e+00 643.00
IUUC-Pno-094815 Phaeosphaeria nodorum 46.30 5.00e-102 364.00
IUUC-Pfo-097089 Poecilia formosa 91.44 0.00e+00 794.00
IUUC-Pab-098421 Pongo abelii 97.80 0.00e+00 837.00
IUUC-Pca-100120 Procavia capensis 72.68 3.00e-161 561.00
IUUC-Pva-102960 Pteropus vampyrus 97.56 0.00e+00 832.00
IUUC-Pgr-103538 Puccinia graminis 46.44 7.00e-115 407.00
IUUC-Ptt-103990 Puccinia triticina 40.78 8.00e-41 162.00
IUUC-Pte-104261 Pyrenophora teres 46.54 6.00e-102 364.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 46.78 2.00e-102 365.00
IUUC-Rno-105123 Rattus norvegicus 97.80 0.00e+00 837.00
IUUC-Sha-107010 Sarcophilus harrisii 96.82 0.00e+00 828.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.19 5.00e-63 234.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 43.88 4.00e-97 348.00
IUUC-Sar-113309 Sorex araneus 99.25 0.00e+00 825.00
IUUC-Sre-115003 Sporisorium reilianum 49.20 2.00e-121 428.00
IUUC-Ssc-116148 Sus scrofa 97.80 0.00e+00 837.00
IUUC-Tgu-117299 Taeniopygia guttata 96.33 0.00e+00 827.00
IUUC-Tru-118179 Takifugu rubripes 89.98 0.00e+00 787.00
IUUC-Tsy-119493 Tarsius syrichta 96.33 0.00e+00 819.00
IUUC-Tni-120355 Tetraodon nigroviridis 90.95 0.00e+00 761.00
IUUC-Tre-121977 Trichoderma reesei 42.61 1.00e-98 353.00
IUUC-Tvi-122661 Trichoderma virens 44.78 2.00e-97 349.00
IUUC-Tme-127031 Tuber melanosporum 47.29 8.00e-101 360.00
IUUC-Tbe-127492 Tupaia belangeri 83.08 1.00e-115 409.00
IUUC-Ttr-128929 Tursiops truncatus 97.56 0.00e+00 833.00
IUUC-Uma-129347 Ustilago maydis 46.91 5.00e-118 417.00
IUUC-Vda-129837 Verticillium dahliae 45.54 9.00e-98 350.00
IUUC-Vpa-130532 Vicugna pacos 83.12 0.00e+00 644.00
IUUC-Xtr-131985 Xenopus tropicalis 95.35 0.00e+00 823.00
IUUC-Xma-133314 Xiphophorus maculatus 91.93 0.00e+00 796.00
IUUC-Yli-134403 Yarrowia lipolytica 40.81 1.00e-73 270.00
Created Date 25-Jun-2017

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