iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027797

UUCD1 version

UUC-DaR-00155

Ensembl Protein ID

ENSDARP00000025140.8

UniProt Accession

Q6E2N3; Q29RE2; TRI33_DANRE

Genbank Protein ID

AAT70732.1; AAI14246.1

Protein Name

E3 ubiquitin-protein ligase TRIM33; Ectodermin homolog; Protein moonshine; RING-type E3 ubiquitin transferase TRIM33; Transcription intermediary factor 1-gamma; Tripartite motif-containing protein 33

Genbank Nucleotide ID

AY598453; BC114245

Gene Name

trim33; mon

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000016181.10	ENSDART00000139603.1	ENSDARP00000113637.1
ENSDARG00000016181.10	ENSDART00000020116.8	ENSDARP00000025140.8

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20447379

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00021	22.7	144	202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf...kdgplvlpCgHvfhadCl....qkw.......pglknssskefrCPlC 45
           Ca+C++++   +++p++lpC H f+++C+     k+       +g+     +  rC +C
   Q: 144  CAVCKQSLqnrDCEPKLLPCLHSFCLKCIpqpdRKItmpvqgpHGQDTRIVNVMRCTVC 202
           ******99888667**************9766433366643332222223333357777 PP

Organism

Danio rerio

Functional Description
(View)

May act as an E3 ubiquitin-protein ligase and a transcriptional repressor (By similarity). Involved in the regulation of embryonic and adult hematopoiesis. Required for normal development and survival of both committed erythroid progenitor cells and posterior mesenchymal cells.

Protein Sequence
(Fasta)

MADNKGQDCT ESSANMEVEA SGTEENGDGG AKEPEAVVSI DTEPKEAADE AKSQETVPQA 60
PTTSSDSSSS GGGGEATDGT PNAESADPPP PPPPPPPPPP STPADSTAAA ASPAVVTEMS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGGAGCA AAGATGGCGG ACAACAAAGG CCAAGATTGT ACGGAGAGCT CCGCAAATAT 60
GGAGGTAGAG GCGTCGGGGA CGGAAGAAAA CGGAGACGGT GGCGCAAAAG AGCCTGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003649--Bbox_C
IPR001487--Bromodomain
IPR019786--Zinc_finger_PHD-type_CS
IPR000315--Znf_B-box
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50014--BROMODOMAIN_2
PS50119--ZF_BBOX
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF00643--zf-B_box

SMART

SM00502--BBC
SM00336--BBOX
SM00297--BROMO
SM00249--PHD
SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0048066--P:developmental pigmentation
GO:0035162--P:embryonic hemopoiesis
GO:0030218--P:erythrocyte differentiation
GO:0033333--P:fin development
GO:0035166--P:post-embryonic hemopoiesis
GO:0060215--P:primitive hemopoiesis
GO:0016567--P:protein ubiquitination
GO:0034243--P:regulation of transcription elongation from RNA polymerase II promoter
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002364	Ailuropoda melanoleuca	72.30	4.00e-169	588.00
IUUC-Apl-003894	Anas platyrhynchos	64.70	0.00e+00	675.00
IUUC-Aca-004658	Anolis carolinensis	73.47	1.00e-146	514.00
IUUC-Ame-011619	Astyanax mexicanus	75.47	0.00e+00	1352.00
IUUC-Bta-013341	Bos taurus	72.93	4.00e-168	585.00
IUUC-Cja-018733	Callithrix jacchus	73.04	3.00e-172	599.00
IUUC-Cfa-020725	Canis familiaris	72.77	2.00e-166	580.00
IUUC-Cpo-021833	Cavia porcellus	73.51	6.00e-172	598.00
IUUC-Csa-023040	Chlorocebus sabaeus	72.48	5.00e-172	598.00
IUUC-Cho-024934	Choloepus hoffmanni	72.00	4.00e-145	509.00
IUUC-Cin-025200	Ciona intestinalis	44.00	1.00e-45	179.00
IUUC-Csv-026278	Ciona savignyi	42.73	3.00e-21	95.10
IUUC-Dno-028955	Dasypus novemcinctus	72.79	3.00e-172	599.00
IUUC-Dor-030744	Dipodomys ordii	41.20	2.00e-72	267.00
IUUC-Dme-032143	Drosophila melanogaster	30.23	1.00e-43	172.00
IUUC-Ete-032728	Echinops telfairi	76.36	5.00e-114	405.00
IUUC-Eca-033573	Equus caballus	73.27	9.00e-172	597.00
IUUC-Eeu-035138	Erinaceus europaeus	59.90	2.00e-129	457.00
IUUC-Fca-035776	Felis catus	75.07	4.00e-151	528.00
IUUC-Fal-037583	Ficedula albicollis	62.75	0.00e+00	706.00
IUUC-Gmo-039353	Gadus morhua	75.13	5.00e-178	619.00
IUUC-Gga-040874	Gallus gallus	62.70	0.00e+00	758.00
IUUC-Gac-041689	Gasterosteus aculeatus	65.79	0.00e+00	1257.00
IUUC-Ggo-045151	Gorilla gorilla	54.77	5.00e-98	352.00
IUUC-Hsa-046169	Homo sapiens	73.04	3.00e-172	599.00
IUUC-Hvu-047073	Hordeum vulgare	44.29	5.00e-13	70.90
IUUC-Itr-048262	Ictidomys tridecemlineatus	56.19	3.00e-139	489.00
IUUC-Lch-050411	Latimeria chalumnae	70.43	2.00e-170	593.00
IUUC-Loc-051992	Lepisosteus oculatus	66.98	0.00e+00	672.00
IUUC-Laf-054552	Loxodonta africana	75.07	2.00e-151	530.00
IUUC-Mcc-055744	Macaca mulatta	72.48	5.00e-172	598.00
IUUC-Meu-056647	Macropus eugenii	73.52	2.00e-156	546.00
IUUC-Mga-059589	Meleagris gallopavo	63.13	0.00e+00	682.00
IUUC-Mmr-060727	Microcebus murinus	72.91	2.00e-171	596.00
IUUC-Mdo-063029	Monodelphis domestica	71.74	3.00e-171	596.00
IUUC-Mmu-064033	Mus musculus	73.28	5.00e-173	602.00
IUUC-Mpu-066679	Mustela putorius furo	72.79	2.00e-171	597.00
IUUC-Mlu-067286	Myotis lucifugus	74.79	8.00e-151	528.00
IUUC-Nle-069156	Nomascus leucogenys	72.86	3.00e-172	599.00
IUUC-Opr-070309	Ochotona princeps	58.69	3.00e-104	373.00
IUUC-Ont-071586	Oreochromis niloticus	77.97	0.00e+00	655.00
IUUC-Oan-073205	Ornithorhynchus anatinus	57.14	6.00e-109	389.00
IUUC-Ocu-074667	Oryctolagus cuniculus	75.07	2.00e-151	530.00
IUUC-Ola-086481	Oryzias latipes	60.68	0.00e+00	1145.00
IUUC-Oga-089101	Otolemur garnettii	73.04	2.00e-172	599.00
IUUC-Oar-090167	Ovis aries	72.79	7.00e-172	598.00
IUUC-Ptr-090901	Pan troglodytes	73.04	3.00e-172	599.00
IUUC-Pan-092448	Papio anubis	72.48	7.00e-172	598.00
IUUC-Psi-093657	Pelodiscus sinensis	63.62	2.00e-168	586.00
IUUC-Pma-094506	Petromyzon marinus	63.64	6.00e-49	185.00
IUUC-Pfo-097104	Poecilia formosa	76.18	8.00e-177	614.00
IUUC-Pab-097704	Pongo abelii	73.04	3.00e-172	599.00
IUUC-Pca-100540	Procavia capensis	52.51	9.00e-112	398.00
IUUC-Pva-102733	Pteropus vampyrus	73.48	3.00e-151	530.00
IUUC-Rno-105512	Rattus norvegicus	73.28	6.00e-173	602.00
IUUC-Sha-107423	Sarcophilus harrisii	54.95	3.00e-150	526.00
IUUC-Sar-113615	Sorex araneus	56.70	9.00e-87	315.00
IUUC-Ssc-115424	Sus scrofa	73.04	6.00e-172	597.00
IUUC-Tgu-117388	Taeniopygia guttata	57.49	1.00e-148	520.00
IUUC-Tru-118728	Takifugu rubripes	62.41	0.00e+00	1107.00
IUUC-Tsy-119053	Tarsius syrichta	75.50	7.00e-150	525.00
IUUC-Tni-120279	Tetraodon nigroviridis	53.04	0.00e+00	673.00
IUUC-Tbe-127573	Tupaia belangeri	63.94	3.00e-128	453.00
IUUC-Ttr-128594	Tursiops truncatus	73.04	3.00e-172	599.00
IUUC-Vpa-130619	Vicugna pacos	50.67	6.00e-84	305.00
IUUC-Xtr-132837	Xenopus tropicalis	71.68	1.00e-164	574.00
IUUC-Xma-133624	Xiphophorus maculatus	76.12	0.00e+00	639.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence