iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Hvu-047563

Ensembl Protein ID

MLOC_55822.2

UniProt Accession

M0WZD0; M0WZD0_HORVV

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MLOC_55822	MLOC_55822.3	MLOC_55822.3
MLOC_55822	MLOC_55822.2	MLOC_55822.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.90e-54	184.3	147	629
UBD/Alpha-Helix/UBA	4.00e-13	50.1	506	545

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw........kskkkavsprellkalkkeaeefsgye 88
           tGl NlgN+CYm Sv+Q++++++++ + ++e +  ++  + ++ +p+ +l ++++kl + ++         + ++ + pr++++++++ ++efs+++
   Q: 147  TGLVNLGNSCYMASVMQVMFSTHPFISRYFEkQSLKAAFAISQADPTLDLNMQMTKLAHGMLsgkysapsPEGQEGIRPRMFKSVIAASHPEFSSMR 243
           7************************99988832233333445689999*************855545554555669********************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvs.sreepfldlslpvpgkeetkk 184
           qqDa Ef ++l+d+++++                           + +++ +   + F++ ++++++c++ + ++ +  ++fl+ls+p+++ +++++
   Q: 244  QQDALEFYHHLIDKVDQAN--------------------------PGNHELN-PCTGFKFIIEERVQCPSGKVSYnQHCDNFLTLSIPLHEATNKEQ 313
           ***************9988..........................3444444.4568************999888788899*********9997766 PP
   S: 185  e...........................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkve 254
           +                            l+ cL+sf+  ee+ +   +y++  ++k++a k+++lk++P++L+l++ +f +  ++++++k++ +++
   Q: 314  LevfhekkaamdldgkelskeeivrprvPLEACLASFSGGEEVPE---FYSTALNSKTTAIKTTGLKTFPDYLVLQMRKF-VMGAGWVPKKLDVYID 406
           69*****************************************96...********************************.77889*********** PP
   S: 255  fpleLdlspfcts.................................................................................... 267
           +p+ +d+s++ ++                                                                                    
   Q: 407  VPDIIDISHMRSHgvqpgeellpegascgnkaesarpvadedivsqlanmgfnyfacqkaaintsnagleeamnwlllhtedpdindpisqdpmpae 503
           ********88888888898888888888888888888887777777777777777777777777777777777777777766666666666666666 PP
   S: 268  ..............................peekqke....................................kkkYeLiavvvHsG.slssGHYva 297
                                         +                                          + +Y+L+a v+H+G s+++GHYva
   Q: 504  dtideaslqtlvsfgfpedvsrmalkasggN-----IeratewvfshpeasnsvsadsststvkddnshisdgSGRYKLTAFVSHMGtSTHCGHYVA 595
           6666555555555555555555555555550.....0555555555555555566666777777788888888************************ PP
   S: 298  yvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           ++ + +g+W  f+D+kV ++   +  +   + +Y++f++r
   Q: 596  HILK-DGRWTIFNDNKVAAS--VDLPK---DMGYLYFFQR 629
           ****.9***********999..68888...999**99997 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           +de  l+ lv+ GF+++  + aL a+++n+e+A+e+++++
   Q: 506  IDEASLQTLVSFGFPEDVSRMALKASGGNIERATEWVFSH 545
           58899*********************************97 PP

Organism

Hordeum vulgare

Protein Sequence
(Fasta)

MDLQQLDNGV IVPPTGWKCS KCDKTENLWL NLTDGMILCG RWVWDGTGGN NHAVEHYQQT 60
KYPLAVKLGT ITADLEGADV YSYPEDDSVE DPILAQHLSH FGIDFSSLQK TEMTTAEREL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCGTGCAGC GCCGGAAGCC GGAGCCGGAC GAGACAGATC GCCCGCTGAA GAAGCCAACC 60
CTGCTCGCCA TCGGTATGAC AGACTTGCAG CTCATAGAAC TTCGTGTTTG TATCGTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	92.09	0.00e+00	1184.00
IUUC-Aml-002104	Ailuropoda melanoleuca	48.04	2.00e-173	601.00
IUUC-Atr-002580	Amborella trichopoda	65.47	2.00e-150	525.00
IUUC-Apl-003774	Anas platyrhynchos	48.61	4.00e-177	613.00
IUUC-Aca-005368	Anolis carolinensis	50.08	2.00e-180	624.00
IUUC-Aly-005727	Arabidopsis lyrata	67.81	0.00e+00	874.00
IUUC-Ath-006974	Arabidopsis thaliana	68.28	0.00e+00	875.00
IUUC-Ago-007890	Ashbya gossypii	31.80	2.00e-67	248.00
IUUC-Acl-008057	Aspergillus clavatus	37.20	4.00e-111	394.00
IUUC-Afl-008547	Aspergillus flavus	37.72	1.00e-105	375.00
IUUC-Afu-008805	Aspergillus fumigatus	36.87	2.00e-99	355.00
IUUC-Ani-009441	Aspergillus nidulans	35.59	3.00e-90	324.00
IUUC-Ang-009720	Aspergillus niger	35.85	1.00e-95	342.00
IUUC-Aor-010111	Aspergillus oryzae	37.72	2.00e-105	375.00
IUUC-Ate-010531	Aspergillus terreus	35.06	1.00e-91	329.00
IUUC-Ame-011470	Astyanax mexicanus	43.97	6.00e-163	566.00
IUUC-Bgr-012183	Blumeria graminis	35.35	1.00e-97	349.00
IUUC-Bta-013179	Bos taurus	48.03	4.00e-174	603.00
IUUC-Bci-013858	Botrytis cinerea	35.32	3.00e-102	365.00
IUUC-Bdi-014904	Brachypodium distachyon	88.92	0.00e+00	1112.00
IUUC-Bol-015536	Brassica oleracea	68.70	0.00e+00	879.00
IUUC-Bra-017939	Brassica rapa	68.23	0.00e+00	875.00
IUUC-Cel-018625	Caenorhabditis elegans	35.22	3.00e-103	368.00
IUUC-Cja-019063	Callithrix jacchus	47.02	3.00e-172	597.00
IUUC-Cfa-020976	Canis familiaris	49.85	3.00e-178	617.00
IUUC-Cpo-022265	Cavia porcellus	49.85	6.00e-178	616.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	41.82	1.00e-121	429.00
IUUC-Csa-024078	Chlorocebus sabaeus	44.59	6.00e-169	586.00
IUUC-Cho-024702	Choloepus hoffmanni	41.84	2.00e-113	402.00
IUUC-Cin-025411	Ciona intestinalis	43.47	1.00e-148	519.00
IUUC-Csv-026347	Ciona savignyi	43.83	2.00e-150	525.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	36.19	3.00e-93	335.00
IUUC-Cne-026831	Cryptococcus neoformans	38.12	4.00e-111	394.00
IUUC-Cme-027335	Cyanidioschyzon merolae	37.97	9.00e-35	141.00
IUUC-Dre-027651	Danio rerio	45.10	7.00e-174	602.00
IUUC-Dno-029034	Dasypus novemcinctus	48.20	2.00e-176	611.00
IUUC-Dor-030479	Dipodomys ordii	47.68	1.00e-85	310.00
IUUC-Dse-031467	Dothistroma septosporum	38.47	4.00e-107	381.00
IUUC-Dme-032075	Drosophila melanogaster	46.91	1.00e-161	562.00
IUUC-Ete-032865	Echinops telfairi	45.30	8.00e-156	543.00
IUUC-Eca-034059	Equus caballus	48.18	1.00e-172	599.00
IUUC-Eeu-035304	Erinaceus europaeus	48.76	8.00e-176	609.00
IUUC-Fca-035515	Felis catus	48.33	1.00e-175	608.00
IUUC-Fal-037271	Ficedula albicollis	50.08	3.00e-175	607.00
IUUC-Fox-037745	Fusarium oxysporum	37.66	6.00e-105	374.00
IUUC-Fso-038158	Fusarium solani	36.59	2.00e-100	358.00
IUUC-Gmo-039071	Gadus morhua	46.50	2.00e-151	528.00
IUUC-Ggr-040098	Gaeumannomyces graminis	35.06	2.00e-98	352.00
IUUC-Gga-040635	Gallus gallus	48.24	1.00e-176	612.00
IUUC-Gac-042528	Gasterosteus aculeatus	44.11	2.00e-154	538.00
IUUC-Gma-043614	Glycine max	66.61	0.00e+00	836.00
IUUC-Ggo-044602	Gorilla gorilla	48.61	1.00e-175	609.00
IUUC-Hsa-045959	Homo sapiens	48.61	1.00e-175	609.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	47.45	2.00e-175	608.00
IUUC-Kpa-049156	Komagataella pastoris	34.46	2.00e-96	345.00
IUUC-Lch-049648	Latimeria chalumnae	48.43	2.00e-176	611.00
IUUC-Lpe-051523	Leersia perrieri	80.84	0.00e+00	1049.00
IUUC-Loc-052072	Lepisosteus oculatus	44.56	1.00e-162	565.00
IUUC-Lma-053216	Leptosphaeria maculans	37.32	9.00e-101	361.00
IUUC-Laf-054327	Loxodonta africana	48.33	1.00e-174	605.00
IUUC-Mcc-055443	Macaca mulatta	48.61	9.00e-176	609.00
IUUC-Meu-056298	Macropus eugenii	52.53	1.00e-115	409.00
IUUC-Mor-057106	Magnaporthe oryzae	36.87	2.00e-106	379.00
IUUC-Mpo-057589	Magnaporthe poae	34.80	4.00e-98	351.00
IUUC-Mtr-058680	Medicago truncatula	66.77	0.00e+00	881.00
IUUC-Mla-058903	Melampsora laricipopulina	34.99	4.00e-97	348.00
IUUC-Mga-059669	Meleagris gallopavo	48.40	3.00e-174	604.00
IUUC-Mvi-060476	Microbotryum violaceum	35.51	3.00e-95	341.00
IUUC-Mmr-060575	Microcebus murinus	48.18	1.00e-174	605.00
IUUC-Mdo-062183	Monodelphis domestica	48.02	1.00e-174	605.00
IUUC-Mmu-063592	Mus musculus	48.10	2.00e-174	604.00
IUUC-Mac-065634	Musa acuminata	64.76	0.00e+00	880.00
IUUC-Mpu-066082	Mustela putorius furo	49.70	2.00e-177	614.00
IUUC-Mlu-067345	Myotis lucifugus	47.17	8.00e-173	599.00
IUUC-Nfi-068558	Neosartorya fischeri	37.95	2.00e-108	385.00
IUUC-Ncr-068960	Neurospora crassa	34.01	3.00e-90	324.00
IUUC-Nle-070173	Nomascus leucogenys	50.00	6.00e-178	616.00
IUUC-Opr-070556	Ochotona princeps	47.89	3.00e-178	617.00
IUUC-Ont-071502	Oreochromis niloticus	47.36	4.00e-156	543.00
IUUC-Oan-072959	Ornithorhynchus anatinus	51.49	2.00e-66	243.00
IUUC-Ocu-074861	Oryctolagus cuniculus	49.70	3.00e-180	624.00
IUUC-Oba-075109	Oryza barthii	83.33	0.00e+00	1070.00
IUUC-Obr-076292	Oryza brachyantha	85.26	0.00e+00	1041.00
IUUC-Ogl-077065	Oryza glaberrima	86.19	0.00e+00	1120.00
IUUC-Ogu-078776	Oryza glumaepatula	83.02	0.00e+00	1073.00
IUUC-Oin-080048	Oryza indica	86.03	0.00e+00	1105.00
IUUC-Olo-080711	Oryza longistaminata	81.14	0.00e+00	1043.00
IUUC-Ome-081506	Oryza meridionalis	83.49	0.00e+00	1060.00
IUUC-Oni-082320	Oryza nivara	83.17	0.00e+00	1069.00
IUUC-Opu-083801	Oryza punctata	83.33	0.00e+00	1027.00
IUUC-Oru-085139	Oryza rufipogon	83.02	0.00e+00	1065.00
IUUC-Osa-085713	Oryza sativa	86.19	0.00e+00	1122.00
IUUC-Ola-086951	Oryzias latipes	44.09	1.00e-149	522.00
IUUC-Olu-087822	Ostreococcus lucimarinus	43.16	2.00e-141	494.00
IUUC-Oga-088625	Otolemur garnettii	47.02	1.00e-173	602.00
IUUC-Oar-089995	Ovis aries	47.08	5.00e-172	596.00
IUUC-Ptr-090640	Pan troglodytes	47.30	1.00e-174	605.00
IUUC-Pan-091974	Papio anubis	47.45	9.00e-174	602.00
IUUC-Psi-093957	Pelodiscus sinensis	48.10	4.00e-180	623.00
IUUC-Pma-094242	Petromyzon marinus	47.03	1.00e-100	358.00
IUUC-Pno-094835	Phaeosphaeria nodorum	36.59	5.00e-101	360.00
IUUC-Ppa-095901	Physcomitrella patens	60.85	0.00e+00	813.00
IUUC-Pfo-097148	Poecilia formosa	46.23	7.00e-156	543.00
IUUC-Pab-098672	Pongo abelii	41.79	4.00e-151	527.00
IUUC-Pop-098943	Populus trichocarpa	68.54	0.00e+00	863.00
IUUC-Pca-100738	Procavia capensis	44.90	2.00e-140	491.00
IUUC-Ppe-101315	Prunus persica	67.85	0.00e+00	867.00
IUUC-Pva-102154	Pteropus vampyrus	47.74	1.00e-171	595.00
IUUC-Pgr-103343	Puccinia graminis	35.76	9.00e-88	316.00
IUUC-Ptt-103928	Puccinia triticina	30.65	2.00e-82	298.00
IUUC-Pte-104306	Pyrenophora teres	35.09	4.00e-90	324.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	35.10	9.00e-94	336.00
IUUC-Rno-105801	Rattus norvegicus	48.33	2.00e-174	605.00
IUUC-Sce-106304	Saccharomyces cerevisiae	32.66	1.00e-72	266.00
IUUC-Sha-107635	Sarcophilus harrisii	49.55	9.00e-177	612.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	35.20	2.00e-89	322.00
IUUC-Spo-108144	Schizosaccharomyces pombe	36.46	1.00e-98	353.00
IUUC-Smo-108703	Selaginella moellendorffii	59.59	0.00e+00	736.00
IUUC-Sit-110728	Setaria italica	84.02	0.00e+00	1100.00
IUUC-Sly-111523	Solanum lycopersicum	66.67	0.00e+00	893.00
IUUC-Sar-113733	Sorex araneus	52.77	2.00e-78	285.00
IUUC-Sbi-114419	Sorghum bicolor	83.70	0.00e+00	1083.00
IUUC-Sre-115225	Sporisorium reilianum	34.76	2.00e-94	338.00
IUUC-Ssc-115686	Sus scrofa	47.31	4.00e-175	607.00
IUUC-Tgu-117346	Taeniopygia guttata	48.32	3.00e-171	593.00
IUUC-Tru-118627	Takifugu rubripes	43.85	8.00e-167	579.00
IUUC-Tsy-119278	Tarsius syrichta	40.50	3.00e-147	514.00
IUUC-Tni-120804	Tetraodon nigroviridis	44.25	2.00e-166	578.00
IUUC-Tca-121585	Theobroma cacao	68.32	0.00e+00	858.00
IUUC-Tre-122043	Trichoderma reesei	36.12	3.00e-99	355.00
IUUC-Tvi-122303	Trichoderma virens	37.11	5.00e-98	350.00
IUUC-Tae-125686	Triticum aestivum	97.31	0.00e+00	1245.00
IUUC-Tur-126732	Triticum urartu	91.46	0.00e+00	1172.00
IUUC-Tme-126909	Tuber melanosporum	36.97	1.00e-94	339.00
IUUC-Tbe-127261	Tupaia belangeri	41.02	2.00e-118	419.00
IUUC-Ttr-129119	Tursiops truncatus	41.38	1.00e-80	293.00
IUUC-Uma-129599	Ustilago maydis	36.97	6.00e-104	370.00
IUUC-Vda-129688	Verticillium dahliae	35.94	2.00e-99	355.00
IUUC-Vpa-130170	Vicugna pacos	37.79	4.00e-131	461.00
IUUC-Vvi-131116	Vitis vinifera	70.52	0.00e+00	872.00
IUUC-Xtr-131953	Xenopus tropicalis	46.93	7.00e-167	579.00
IUUC-Xma-133837	Xiphophorus maculatus	46.08	2.00e-155	541.00
IUUC-Yli-134510	Yarrowia lipolytica	36.16	5.00e-98	350.00
IUUC-Zma-135786	Zea mays	81.80	0.00e+00	1030.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence