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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Spo-108082
UUCD1 version UUC-ScP-00087
Ensembl Protein ID SPBC1A4.01.1:pep
UniProt Accession O42971; APC10_SCHPO
Genbank Protein ID CAA16839.1; BAA32157.1
Protein Name Anaphase-promoting complex subunit 10; 20S cyclosome/APC complex protein apc10
Genbank Nucleotide ID CU329671; AB012919
Gene Name apc10; SPBC1A4.01; SPBC1E8.06
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SPBC1A4.01 SPBC1A4.01.1 SPBC1A4.01.1:pep
Annotation
mRNA Expression
GEO
Protein-protein Interaction
iRefIndexHINTMentha
Protein Expression/Proteomics
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 44.90 7.00e-36 147.00 IUUC-Hsa-046971
E3 adaptor/Cullin RING/APC_C/APC_C 37.24 9.00e-26 110.00 IUUC-Sce-106448
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Schizosaccharomyces pombe
Functional Description
(View)

Functional Description


     Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to nitrogen starvation. Required for ubiquitination and degradation of the mitotic B-type cyclin, cdc13.
 Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to nitrogen starvation. Required for ubiquitination and degradation of the mitotic B-type cyclin, cdc13.
Protein Sequence
(Fasta)
MAQIRQEALK KQKSETQKST EGFVDIGNLA QWTCSSEKSG FPIRLVRDDN IDTYWQSDGS 60
QPHTIHIKFV KRVSIKYVSM YLQYTLDESY TPSTLRISAG TGFQDLEIVT TVQVEEPTGW 120
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Protein Fasta Sequence


>IUUC-Spo-108082|E3,APC_C|Schizosaccharomyces pombe
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Nucleotide Sequence
(Fasta)
AGCCTTGGGA GGACGTTATG TCAACATCTC ACAAGTCCGC ATTGTTTACA TTTAGCTTAT 60
GGCGCAAATT CGACAAGAAG CATTGAAAAA ACAAAAGTCT GAGACGCAAA AATCAACAGA 120
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Nucleotide Fasta Sequence


>IUUC-Spo-108082|E3,APC_C|Schizosaccharomyces pombe
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR016901--APC10
IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
PROSITE

PS51284--DOC
Pfam

PF03256--ANAPC10
SMART

SM01337--APC10
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
GO:0030071--P:regulation of mitotic metaphase/anaphase transition
KEGG spo:SPBC1A4.01
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000560 Aegilops tauschii 43.68 4.00e-18 81.60
IUUC-Aml-001522 Ailuropoda melanoleuca 44.90 8.00e-38 147.00
IUUC-Atr-002797 Amborella trichopoda 36.42 2.00e-35 139.00
IUUC-Apl-004185 Anas platyrhynchos 44.22 6.00e-38 148.00
IUUC-Aca-004900 Anolis carolinensis 44.22 5.00e-38 148.00
IUUC-Aly-005760 Arabidopsis lyrata 42.17 1.00e-33 134.00
IUUC-Ath-007516 Arabidopsis thaliana 42.17 1.00e-33 133.00
IUUC-Ago-007889 Ashbya gossypii 42.20 1.00e-34 137.00
IUUC-Acl-008130 Aspergillus clavatus 41.58 4.00e-21 94.00
IUUC-Afl-008640 Aspergillus flavus 44.04 6.00e-22 96.30
IUUC-Afu-009101 Aspergillus fumigatus 40.59 8.00e-20 89.40
IUUC-Ani-009484 Aspergillus nidulans 42.28 8.00e-23 99.40
IUUC-Ang-009847 Aspergillus niger 37.12 4.00e-20 90.90
IUUC-Aor-010077 Aspergillus oryzae 44.04 6.00e-22 96.30
IUUC-Ate-010544 Aspergillus terreus 44.04 4.00e-22 97.10
IUUC-Ame-011330 Astyanax mexicanus 43.94 3.00e-34 135.00
IUUC-Bgr-011978 Blumeria graminis 44.90 1.00e-33 134.00
IUUC-Bta-013351 Bos taurus 44.90 8.00e-38 147.00
IUUC-Bci-013611 Botrytis cinerea 43.15 5.00e-33 132.00
IUUC-Bdi-014443 Brachypodium distachyon 41.98 1.00e-34 137.00
IUUC-Bol-015534 Brassica oleracea 41.57 8.00e-38 147.00
IUUC-Bra-017298 Brassica rapa 41.57 8.00e-38 147.00
IUUC-Cel-018170 Caenorhabditis elegans 38.46 1.00e-28 117.00
IUUC-Cja-019877 Callithrix jacchus 44.90 8.00e-38 147.00
IUUC-Cfa-020698 Canis familiaris 44.90 8.00e-38 147.00
IUUC-Cpo-022007 Cavia porcellus 44.90 8.00e-38 147.00
IUUC-Cre-023013 Chlamydomonas reinhardtii 41.73 7.00e-35 137.00
IUUC-Csa-023980 Chlorocebus sabaeus 44.90 8.00e-38 147.00
IUUC-Cho-024703 Choloepus hoffmanni 44.27 2.00e-33 132.00
IUUC-Cin-025346 Ciona intestinalis 40.67 3.00e-34 135.00
IUUC-Csv-026225 Ciona savignyi 36.42 2.00e-29 119.00
IUUC-Cgl-026544 Colletotrichum gloeosporioides 38.12 1.00e-30 124.00
IUUC-Cne-027042 Cryptococcus neoformans 37.41 1.00e-29 120.00
IUUC-Cme-027223 Cyanidioschyzon merolae 39.42 3.00e-25 107.00
IUUC-Dre-027804 Danio rerio 44.22 2.00e-38 149.00
IUUC-Dno-029995 Dasypus novemcinctus 44.90 8.00e-38 147.00
IUUC-Dor-030429 Dipodomys ordii 44.90 1.00e-37 147.00
IUUC-Dse-031499 Dothistroma septosporum 36.65 6.00e-30 122.00
IUUC-Dme-031675 Drosophila melanogaster 46.15 2.00e-36 143.00
IUUC-Ete-032499 Echinops telfairi 45.07 2.00e-36 142.00
IUUC-Eca-034281 Equus caballus 44.90 8.00e-38 147.00
IUUC-Eeu-034913 Erinaceus europaeus 45.00 3.00e-27 111.00
IUUC-Fca-036364 Felis catus 44.90 9.00e-38 147.00
IUUC-Fal-037041 Ficedula albicollis 44.22 6.00e-38 148.00
IUUC-Fox-037777 Fusarium oxysporum 40.82 9.00e-31 126.00
IUUC-Fso-038311 Fusarium solani 43.24 8.00e-32 129.00
IUUC-Gmo-039318 Gadus morhua 38.61 1.00e-20 89.70
IUUC-Ggr-039935 Gaeumannomyces graminis 39.33 2.00e-27 114.00
IUUC-Gga-041006 Gallus gallus 42.17 4.00e-38 148.00
IUUC-Gac-042367 Gasterosteus aculeatus 43.54 4.00e-38 148.00
IUUC-Gma-043650 Glycine max 42.07 4.00e-38 149.00
IUUC-Ggo-045044 Gorilla gorilla 44.90 8.00e-38 147.00
IUUC-Hsa-046971 Homo sapiens 44.90 8.00e-38 147.00
IUUC-Hvu-047485 Hordeum vulgare 38.71 6.00e-07 43.10
IUUC-Itr-048324 Ictidomys tridecemlineatus 46.99 8.00e-22 93.20
IUUC-Kpa-049293 Komagataella pastoris 38.97 2.00e-36 143.00
IUUC-Lch-049462 Latimeria chalumnae 44.70 2.00e-33 132.00
IUUC-Lpe-050846 Leersia perrieri 40.74 1.00e-33 133.00
IUUC-Loc-052857 Lepisosteus oculatus 44.22 7.00e-39 150.00
IUUC-Lma-052974 Leptosphaeria maculans 40.48 3.00e-15 73.90
IUUC-Laf-053536 Loxodonta africana 44.90 8.00e-38 147.00
IUUC-Mcc-054806 Macaca mulatta 44.90 8.00e-38 147.00
IUUC-Meu-056282 Macropus eugenii 37.97 1.00e-11 60.50
IUUC-Mor-057080 Magnaporthe oryzae 39.58 2.00e-27 114.00
IUUC-Mpo-057503 Magnaporthe poae 38.56 8.00e-28 115.00
IUUC-Mtr-057837 Medicago truncatula 40.00 1.00e-37 147.00
IUUC-Mla-059010 Melampsora laricipopulina 40.71 7.00e-29 117.00
IUUC-Mga-059728 Meleagris gallopavo 44.22 6.00e-38 148.00
IUUC-Mvi-060224 Microbotryum violaceum 36.17 1.00e-32 130.00
IUUC-Mdo-062602 Monodelphis domestica 44.22 6.00e-38 148.00
IUUC-Mmu-063528 Mus musculus 44.90 8.00e-38 147.00
IUUC-Mac-065629 Musa acuminata 40.96 6.00e-34 134.00
IUUC-Mpu-066046 Mustela putorius furo 44.90 8.00e-38 147.00
IUUC-Mlu-068107 Myotis lucifugus 44.90 8.00e-38 147.00
IUUC-Nfi-068426 Neosartorya fischeri 40.59 1.00e-19 89.40
IUUC-Ncr-068810 Neurospora crassa 41.36 9.00e-31 125.00
IUUC-Nle-069550 Nomascus leucogenys 44.90 8.00e-38 147.00
IUUC-Opr-071205 Ochotona princeps 45.00 2.00e-36 142.00
IUUC-Ont-071625 Oreochromis niloticus 42.86 9.00e-37 144.00
IUUC-Oan-073396 Ornithorhynchus anatinus 44.22 5.00e-38 148.00
IUUC-Ocu-074136 Oryctolagus cuniculus 44.90 8.00e-38 147.00
IUUC-Oba-075504 Oryza barthii 41.36 4.00e-34 135.00
IUUC-Obr-076300 Oryza brachyantha 41.36 3.00e-35 139.00
IUUC-Ogl-077163 Oryza glaberrima 41.36 4.00e-34 135.00
IUUC-Ogu-078459 Oryza glumaepatula 41.36 4.00e-34 135.00
IUUC-Oin-079095 Oryza indica 36.41 5.00e-30 122.00
IUUC-Olo-080226 Oryza longistaminata 37.16 3.00e-30 125.00
IUUC-Ome-081690 Oryza meridionalis 41.36 4.00e-34 135.00
IUUC-Oni-082984 Oryza nivara 41.36 4.00e-34 135.00
IUUC-Opu-083753 Oryza punctata 40.74 2.00e-37 146.00
IUUC-Oru-084459 Oryza rufipogon 41.36 4.00e-34 135.00
IUUC-Osa-085969 Oryza sativa 41.36 4.00e-34 135.00
IUUC-Ola-087291 Oryzias latipes 43.54 3.00e-38 148.00
IUUC-Olu-087704 Ostreococcus lucimarinus 42.66 6.00e-36 142.00
IUUC-Oga-088086 Otolemur garnettii 44.90 8.00e-38 147.00
IUUC-Oar-089191 Ovis aries 44.90 8.00e-38 147.00
IUUC-Ptr-091583 Pan troglodytes 44.90 8.00e-38 147.00
IUUC-Pan-092440 Papio anubis 44.90 8.00e-38 147.00
IUUC-Psi-093158 Pelodiscus sinensis 44.22 6.00e-38 148.00
IUUC-Pma-094382 Petromyzon marinus 44.23 3.00e-11 57.40
IUUC-Pno-094776 Phaeosphaeria nodorum 41.24 1.00e-18 85.50
IUUC-Ppa-095243 Physcomitrella patens 38.35 1.00e-28 117.00
IUUC-Pfo-096853 Poecilia formosa 43.54 4.00e-38 148.00
IUUC-Pab-098464 Pongo abelii 44.27 2.00e-33 132.00
IUUC-Pop-099055 Populus trichocarpa 42.59 1.00e-35 140.00
IUUC-Pca-100402 Procavia capensis 43.51 2.00e-32 129.00
IUUC-Ppe-101826 Prunus persica 43.83 8.00e-37 144.00
IUUC-Pva-102272 Pteropus vampyrus 44.90 8.00e-38 147.00
IUUC-Pgr-103519 Puccinia graminis 40.25 7.00e-32 128.00
IUUC-Ptt-103904 Puccinia triticina 40.21 4.00e-15 72.00
IUUC-Pte-104017 Pyrenophora teres 42.27 2.00e-19 88.60
IUUC-Pyt-104453 Pyrenophora triticirepentis 41.24 3.00e-19 87.00
IUUC-Rno-105561 Rattus norvegicus 44.90 8.00e-38 147.00
IUUC-Sce-106448 Saccharomyces cerevisiae 37.24 1.00e-26 110.00
IUUC-Sha-106901 Sarcophilus harrisii 44.22 6.00e-38 148.00
IUUC-Sja-107924 Schizosaccharomyces japonicus 66.48 2.00e-72 262.00
IUUC-Ssl-108422 Sclerotinia sclerotiorum 40.00 3.00e-33 133.00
IUUC-Smo-109182 Selaginella moellendorffii 40.00 2.00e-37 145.00
IUUC-Sit-110070 Setaria italica 42.59 8.00e-36 141.00
IUUC-Sly-111772 Solanum lycopersicum 39.76 5.00e-32 128.00
IUUC-Stu-112789 Solanum tuberosum 39.76 3.00e-32 129.00
IUUC-Sar-113731 Sorex araneus 31.68 1.00e-11 60.80
IUUC-Sbi-114468 Sorghum bicolor 42.17 1.00e-39 153.00
IUUC-Sre-115201 Sporisorium reilianum 30.98 5.00e-24 102.00
IUUC-Ssc-115318 Sus scrofa 44.90 8.00e-38 147.00
IUUC-Tgu-116782 Taeniopygia guttata 44.22 5.00e-38 148.00
IUUC-Tru-117918 Takifugu rubripes 43.54 5.00e-38 148.00
IUUC-Tni-120731 Tetraodon nigroviridis 43.54 3.00e-38 149.00
IUUC-Tca-121546 Theobroma cacao 43.21 1.00e-35 140.00
IUUC-Tre-122092 Trichoderma reesei 41.96 7.00e-30 120.00
IUUC-Tvi-122416 Trichoderma virens 42.36 2.00e-30 124.00
IUUC-Tae-125041 Triticum aestivum 41.24 6.00e-36 141.00
IUUC-Tur-126519 Triticum urartu 40.68 5.00e-34 135.00
IUUC-Tme-127131 Tuber melanosporum 46.59 1.00e-43 167.00
IUUC-Tbe-128098 Tupaia belangeri 46.99 8.00e-22 93.20
IUUC-Ttr-128765 Tursiops truncatus 40.14 2.00e-30 123.00
IUUC-Uma-129533 Ustilago maydis 31.55 2.00e-24 103.00
IUUC-Vda-129741 Verticillium dahliae 42.18 6.00e-32 129.00
IUUC-Vpa-130667 Vicugna pacos 44.90 8.00e-38 147.00
IUUC-Vvi-131400 Vitis vinifera 42.35 4.00e-39 152.00
IUUC-Xtr-132526 Xenopus tropicalis 42.86 8.00e-38 147.00
IUUC-Xma-133326 Xiphophorus maculatus 43.54 5.00e-38 148.00
IUUC-Yli-134645 Yarrowia lipolytica 44.17 2.00e-37 146.00
IUUC-Zma-135101 Zea mays 42.59 1.00e-38 150.00
Created Date 25-Jun-2017

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