iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046288

UUCD1 version

UUC-HoS-00212

Ensembl Protein ID

ENSP00000319482.3

UniProt Accession

Q8IWE4; B3KVY4; DCNL3_HUMAN

Genbank Protein ID

AAQ76806.1; BAG53946.1; EAW66842.1; AAH40442.1

Protein Name

DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3; Squamous cell carcinoma-related oncogene 3

Genbank Nucleotide ID

AY364247; AK123719; CH471228; BC040442

Gene Name

DCUN1D3; SCCRO3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000188215.9	ENST00000324344.8	ENSP00000319482.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/DCUN1	DCUN1	19617556

Classification

Family	E-value	Score	Start	End
E3 activity/DCUN1	3.00e-84	283.5	87	278

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkdeqk 93
           s ++leelf+rYkd++ed+i++eg+e+fc+dl+vdp++++vL+lawk++aat+c+f+r+ef+dg++a+++dsi+++++++++l +e+k+e+k
   Q: 87   SLQRLEELFRRYKDEREDAILEEGMERFCNDLCVDPTEFRVLLLAWKFQAATMCKFTRKEFFDGCKAISADSIDGICARFPSLLTEAKQEDK 178
           679***************************************************************************************** PP
   S: 94   fkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeegaWPvli 181
           fkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++++ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++aWP+l+
   Q: 179  FKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNNPPVLDQWLNFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDEAWPSLF 270
           ************998899**********************************9889************************************ PP
   S: 182  Defveylk 189
           D+fve+++
   Q: 271  DTFVEWEM 278
           ******85 PP

Organism

Homo sapiens

Functional Description
(View)

Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane (PubMed:25349211). When overexpressed in transformed cells, may promote mesenchymal to epithelial-like changes and inhibit colony formation in soft agar (PubMed:25349211).

Protein Sequence
(Fasta)

MGQCVTKCKN PSSTLGSKNG DREPSNKSHS RRGAGHREEQ VPPCGKPGGD ILVNGTKKAE 60
AATEACQLPT SSGDAGRESK SNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGGCGGCC GCCGCCGGTG GGCCGCAGAT GAAGAGGAGG CGGTGGCAGT GGTGGAAGAA 60
GAGGCGGCGG CGGCGGGGGT AGGGAGCCTG GAAACGCGAG CGGGGATGGT AGGTGGTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0030308--P:negative regulation of cell growth
GO:0043065--P:positive regulation of apoptotic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
GO:0010332--P:response to gamma radiation
GO:0010225--P:response to UV-C

KEGG

hsa:123879

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001689	Ailuropoda melanoleuca	97.04	4.00e-166	577.00
IUUC-Apl-003497	Anas platyrhynchos	82.57	2.00e-143	501.00
IUUC-Aca-004961	Anolis carolinensis	80.59	2.00e-146	511.00
IUUC-Aor-009902	Aspergillus oryzae	33.83	2.00e-11	60.80
IUUC-Ame-011413	Astyanax mexicanus	63.25	1.00e-99	356.00
IUUC-Bta-013338	Bos taurus	97.04	6.00e-167	579.00
IUUC-Cja-019458	Callithrix jacchus	99.34	2.00e-171	594.00
IUUC-Cfa-020160	Canis familiaris	97.37	6.00e-167	579.00
IUUC-Cpo-021835	Cavia porcellus	98.03	2.00e-159	554.00
IUUC-Csa-023328	Chlorocebus sabaeus	99.67	6.00e-172	596.00
IUUC-Cho-024888	Choloepus hoffmanni	95.36	1.00e-164	572.00
IUUC-Cin-025134	Ciona intestinalis	52.24	4.00e-60	225.00
IUUC-Csv-025904	Ciona savignyi	50.41	2.00e-32	130.00
IUUC-Dre-027780	Danio rerio	64.03	2.00e-97	348.00
IUUC-Dno-028866	Dasypus novemcinctus	97.04	2.00e-165	574.00
IUUC-Dor-030387	Dipodomys ordii	98.03	2.00e-168	584.00
IUUC-Dme-032081	Drosophila melanogaster	45.61	2.00e-48	186.00
IUUC-Eca-033857	Equus caballus	97.04	3.00e-167	580.00
IUUC-Eeu-034825	Erinaceus europaeus	89.80	2.00e-151	528.00
IUUC-Fca-036130	Felis catus	97.70	7.00e-168	582.00
IUUC-Fal-037296	Ficedula albicollis	82.57	3.00e-142	497.00
IUUC-Gmo-039626	Gadus morhua	64.77	3.00e-98	351.00
IUUC-Ggr-039959	Gaeumannomyces graminis	26.64	4.00e-15	76.60
IUUC-Gga-040741	Gallus gallus	81.91	4.00e-140	490.00
IUUC-Gac-042271	Gasterosteus aculeatus	66.55	2.00e-92	332.00
IUUC-Ggo-044727	Gorilla gorilla	99.67	6.00e-172	596.00
IUUC-Itr-049054	Ictidomys tridecemlineatus	98.36	7.00e-179	619.00
IUUC-Lch-050289	Latimeria chalumnae	78.22	5.00e-133	466.00
IUUC-Loc-052455	Lepisosteus oculatus	72.30	3.00e-108	384.00
IUUC-Laf-054369	Loxodonta africana	95.39	2.00e-158	551.00
IUUC-Mcc-055413	Macaca mulatta	79.55	1.00e-123	435.00
IUUC-Meu-056535	Macropus eugenii	86.51	3.00e-152	530.00
IUUC-Mga-059290	Meleagris gallopavo	82.57	3.00e-142	497.00
IUUC-Mmr-060689	Microcebus murinus	99.67	1.00e-171	595.00
IUUC-Mdo-062128	Monodelphis domestica	86.84	4.00e-147	513.00
IUUC-Mmu-064396	Mus musculus	97.70	2.00e-177	614.00
IUUC-Mpu-065926	Mustela putorius furo	97.04	4.00e-166	577.00
IUUC-Mlu-067044	Myotis lucifugus	95.07	1.00e-172	598.00
IUUC-Nle-069346	Nomascus leucogenys	99.67	6.00e-172	596.00
IUUC-Opr-070682	Ochotona princeps	98.36	5.00e-158	550.00
IUUC-Ont-071772	Oreochromis niloticus	68.46	5.00e-101	360.00
IUUC-Oan-072765	Ornithorhynchus anatinus	83.55	1.00e-144	505.00
IUUC-Ocu-074272	Oryctolagus cuniculus	92.74	2.00e-119	421.00
IUUC-Ola-087561	Oryzias latipes	68.75	2.00e-107	381.00
IUUC-Oga-088440	Otolemur garnettii	78.72	3.00e-125	441.00
IUUC-Oar-089403	Ovis aries	97.37	1.00e-167	582.00
IUUC-Ptr-091384	Pan troglodytes	99.67	6.00e-172	596.00
IUUC-Pan-092650	Papio anubis	99.67	6.00e-172	596.00
IUUC-Psi-093806	Pelodiscus sinensis	83.22	8.00e-135	473.00
IUUC-Pma-094196	Petromyzon marinus	51.89	9.00e-88	316.00
IUUC-Pfo-096584	Poecilia formosa	69.29	4.00e-105	374.00
IUUC-Pab-098605	Pongo abelii	99.67	6.00e-172	596.00
IUUC-Pca-100933	Procavia capensis	79.28	2.00e-116	411.00
IUUC-Pva-102172	Pteropus vampyrus	92.51	3.00e-161	560.00
IUUC-Rno-105406	Rattus norvegicus	98.03	3.00e-178	617.00
IUUC-Sha-106531	Sarcophilus harrisii	86.18	1.00e-152	531.00
IUUC-Sar-113051	Sorex araneus	76.97	3.00e-117	414.00
IUUC-Ssc-115555	Sus scrofa	97.37	7.00e-168	582.00
IUUC-Tgu-117178	Taeniopygia guttata	82.89	5.00e-144	503.00
IUUC-Tru-117876	Takifugu rubripes	66.78	4.00e-105	374.00
IUUC-Tsy-118790	Tarsius syrichta	97.05	9.00e-137	479.00
IUUC-Tni-119673	Tetraodon nigroviridis	66.56	4.00e-107	380.00
IUUC-Tbe-127429	Tupaia belangeri	98.68	1.00e-170	592.00
IUUC-Ttr-128467	Tursiops truncatus	97.70	2.00e-168	584.00
IUUC-Vpa-130376	Vicugna pacos	67.64	2.00e-96	345.00
IUUC-Xtr-132134	Xenopus tropicalis	79.27	7.00e-123	433.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence