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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046148
UUCD1 version UUC-HoS-00006
Ensembl Protein ID ENSP00000352069.2
UniProt Accession O00308; A6NEP1; B2R706; B4DTL5; F5H213; H3BRF3; I3RSG8; Q6ZTQ5; Q96CZ2; Q9BWN6; WWP2_HUMAN
Genbank Protein ID AAC51325.1; AFK29253.1; BAC86528.1; BAG62027.1; BAG35653.1; EAW83287.1; AAH00108.1; AAH13645.1; AAH64531.1
Protein Name NEDD4-like E3 ubiquitin-protein ligase WWP2; Atrophin-1-interacting protein 2; HECT-type E3 ubiquitin transferase WWP2; WW domain-containing protein 2
Genbank Nucleotide ID U96114; JN712744; AK126332; AK300266; AK312792; AC026468; BC000108; BC013645; BC064531
Gene Name WWP2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198373.12 ENST00000359154.6 ENSP00000352069.2
ENSG00000198373.12 ENST00000569620.5 ENSP00000456582.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 20522958; 19651900; 15047715; 12202215
Classification
Family E-value Score Start End
E3 activity/HECT 1.50e-135 453.6 537 869
Active Site
Position(s) Description Evidence
838 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+ ++
   Q: 537  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDTGFT 627
           6799********************************************************9.89**************************** PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkeg 185
            +fyk++l+k+ +l+dle++dpe+y+s+ +iken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l++++r+++g
   Q: 628  LPFYKRMLNKRPTLKDLESIDPEFYNSIVWIKEN---NLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTDWRFTRG 716
           ********************************99...9****************************************************** PP
   S: 186  ikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlg 277
           ++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k t y++ yt++s++iqwFw+v++e+++e+r ++LqFvTg++rlP+g
   Q: 717  VEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKSTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGTCRLPVG 807
           **************************************************99.*************************************** PP
   S: 278  Gfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Gfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+l+ekLlyAieet+gF++
   Q: 808  GFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLREKLLYAIEETEGFGQ 869
           ************************************************************96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Protein Sequence
(Fasta)
MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 60
GSSELLWNEI IILNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENMQLT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046148|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCGGTCAC GTGACCCGGC CCGAGTGCGG GCGGTGGAAG GCGGAAGTAG GAGAGGAGTT 60
CGGCGCCGCT TCTGTGGCCA CGGCAGGTAG CGAGCGCTGG CGCGGGGGGC GCGGTGGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046148|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0945--Host-virus interaction
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0008134--F:transcription factor binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006464--P:cellular protein modification process
GO:0010629--P:negative regulation of gene expression
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0034765--P:regulation of ion transmembrane transport
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0046718--P:viral entry into host cell
KEGG hsa:11060
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001575 Ailuropoda melanoleuca 96.10 0.00e+00 1642.00
IUUC-Apl-003912 Anas platyrhynchos 77.16 0.00e+00 1246.00
IUUC-Aca-004291 Anolis carolinensis 81.49 0.00e+00 1443.00
IUUC-Bta-013231 Bos taurus 95.29 0.00e+00 1599.00
IUUC-Cel-018299 Caenorhabditis elegans 67.18 0.00e+00 831.00
IUUC-Cja-019455 Callithrix jacchus 98.28 0.00e+00 1717.00
IUUC-Cfa-021017 Canis familiaris 96.55 0.00e+00 1629.00
IUUC-Cpo-021988 Cavia porcellus 95.98 0.00e+00 1674.00
IUUC-Csa-023549 Chlorocebus sabaeus 98.51 0.00e+00 1731.00
IUUC-Dre-028513 Danio rerio 92.12 0.00e+00 1138.00
IUUC-Dno-028976 Dasypus novemcinctus 95.64 0.00e+00 1669.00
IUUC-Dor-030176 Dipodomys ordii 92.79 0.00e+00 1509.00
IUUC-Eca-033949 Equus caballus 96.32 0.00e+00 1650.00
IUUC-Eeu-034529 Erinaceus europaeus 88.22 0.00e+00 1374.00
IUUC-Fca-036236 Felis catus 96.09 0.00e+00 1678.00
IUUC-Fal-036948 Ficedula albicollis 78.88 0.00e+00 1337.00
IUUC-Gmo-038842 Gadus morhua 89.42 0.00e+00 1070.00
IUUC-Gga-040617 Gallus gallus 80.42 0.00e+00 1439.00
IUUC-Gac-041338 Gasterosteus aculeatus 70.01 0.00e+00 1248.00
IUUC-Ggo-045278 Gorilla gorilla 99.77 0.00e+00 1749.00
IUUC-Itr-047945 Ictidomys tridecemlineatus 98.13 0.00e+00 1120.00
IUUC-Lch-050663 Latimeria chalumnae 78.37 0.00e+00 1394.00
IUUC-Loc-052604 Lepisosteus oculatus 75.20 0.00e+00 1320.00
IUUC-Laf-053944 Loxodonta africana 96.09 0.00e+00 1669.00
IUUC-Mcc-055655 Macaca mulatta 98.74 0.00e+00 1734.00
IUUC-Meu-055953 Macropus eugenii 80.16 0.00e+00 1386.00
IUUC-Mga-060190 Meleagris gallopavo 80.81 0.00e+00 1437.00
IUUC-Mmr-060896 Microcebus murinus 97.11 0.00e+00 1649.00
IUUC-Mdo-062536 Monodelphis domestica 91.06 0.00e+00 1610.00
IUUC-Mmu-064017 Mus musculus 95.98 0.00e+00 1657.00
IUUC-Mpu-066608 Mustela putorius furo 93.92 0.00e+00 1590.00
IUUC-Mlu-067623 Myotis lucifugus 92.88 0.00e+00 1593.00
IUUC-Nle-069496 Nomascus leucogenys 97.24 0.00e+00 1694.00
IUUC-Opr-071054 Ochotona princeps 84.57 0.00e+00 1431.00
IUUC-Ont-071279 Oreochromis niloticus 74.11 0.00e+00 1285.00
IUUC-Oan-073512 Ornithorhynchus anatinus 88.41 0.00e+00 1498.00
IUUC-Ocu-074271 Oryctolagus cuniculus 95.57 0.00e+00 1626.00
IUUC-Ola-087237 Oryzias latipes 85.98 0.00e+00 1051.00
IUUC-Oga-088164 Otolemur garnettii 96.90 0.00e+00 1689.00
IUUC-Oar-089698 Ovis aries 95.63 0.00e+00 1610.00
IUUC-Ptr-091306 Pan troglodytes 98.51 0.00e+00 1719.00
IUUC-Pan-092814 Papio anubis 94.84 0.00e+00 1637.00
IUUC-Pfo-096709 Poecilia formosa 90.56 0.00e+00 1084.00
IUUC-Pab-098494 Pongo abelii 93.71 0.00e+00 1647.00
IUUC-Pca-100596 Procavia capensis 83.92 0.00e+00 1380.00
IUUC-Pva-103154 Pteropus vampyrus 91.56 0.00e+00 1571.00
IUUC-Rno-104954 Rattus norvegicus 95.38 0.00e+00 1416.00
IUUC-Sha-106781 Sarcophilus harrisii 91.40 0.00e+00 1652.00
IUUC-Ssc-116307 Sus scrofa 84.18 0.00e+00 1446.00
IUUC-Tgu-116530 Taeniopygia guttata 76.35 0.00e+00 1196.00
IUUC-Tru-118287 Takifugu rubripes 89.81 0.00e+00 1069.00
IUUC-Tsy-119097 Tarsius syrichta 84.12 0.00e+00 1244.00
IUUC-Tni-120801 Tetraodon nigroviridis 68.04 0.00e+00 1140.00
IUUC-Tbe-127793 Tupaia belangeri 84.94 0.00e+00 1449.00
IUUC-Ttr-128275 Tursiops truncatus 91.38 0.00e+00 1550.00
IUUC-Xtr-132866 Xenopus tropicalis 82.39 0.00e+00 1131.00
Created Date 25-Jun-2017

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