iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071239

Ensembl Protein ID

ENSONIP00000010417.1

UniProt Accession

I3JNH3; I3JNH3_ORENI

Genbank Protein ID

ENSONIP00000010417

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01009067

Gene Name

smurf2; LOC100691078

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000008278.1	ENSONIT00000010426.1	ENSONIP00000010417.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.90e-130	433.2	426	758

Active Site

Position(s)	Description	Evidence
727	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 426  PKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 513
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++i+Vt++ k+eYv+l+v+
   Q: 514  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSISVTQDTKKEYVRLYVN 598
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll++F+e+elel++cG  +id++d+k++t+ k+ +t+ds+ ++wFw+++e+f++e r+++LqFv
   Q: 599  WRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKH-CTPDSNIVKWFWKAVESFDEERRARLLQFV 686
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+++l++kLl+Aieet gF +
   Q: 687  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYDKLYDKLLTAIEETCGFAV 758
           **********************************************************************76 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

FSNQQNIAGA QQRGGCLPLS YSLLCAKNLV KKDFFRLPDP FAKVVVDGSG QCHSTDTVRN 60
TLDPKWNQHY DLYIGKSDSI TISVWNHKKI HKKQGAGFLG CVRLLSNAIN RLKDTGYQRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCTAACC AGGGAATTTA AAAAACTAAA CTCAAAGGAA AATGCATAAA AATAAAATCC 60
ACAGTTTCAG ATGGAAGAAA AAAAACATGC TGCAGATTTT TACCCTTAAG TTGCAAAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	92.59	0.00e+00	1410.00
IUUC-Apl-003513	Anas platyrhynchos	93.37	0.00e+00	1431.00
IUUC-Bta-013399	Bos taurus	92.55	0.00e+00	1400.00
IUUC-Cja-019355	Callithrix jacchus	92.45	0.00e+00	1404.00
IUUC-Cpo-022200	Cavia porcellus	92.84	0.00e+00	1409.00
IUUC-Cho-024804	Choloepus hoffmanni	94.82	1.00e-179	623.00
IUUC-Cin-025126	Ciona intestinalis	65.44	0.00e+00	966.00
IUUC-Csv-026339	Ciona savignyi	63.98	0.00e+00	1001.00
IUUC-Dno-029534	Dasypus novemcinctus	91.86	0.00e+00	1408.00
IUUC-Ete-032715	Echinops telfairi	88.33	0.00e+00	1318.00
IUUC-Eca-033580	Equus caballus	92.83	0.00e+00	1406.00
IUUC-Eeu-034945	Erinaceus europaeus	91.48	0.00e+00	1307.00
IUUC-Fal-037275	Ficedula albicollis	93.40	0.00e+00	1431.00
IUUC-Gmo-039234	Gadus morhua	89.43	0.00e+00	785.00
IUUC-Gac-041295	Gasterosteus aculeatus	96.90	0.00e+00	1506.00
IUUC-Hsa-046726	Homo sapiens	91.99	0.00e+00	1407.00
IUUC-Laf-053753	Loxodonta africana	92.69	0.00e+00	1405.00
IUUC-Meu-056436	Macropus eugenii	70.89	0.00e+00	1033.00
IUUC-Mpo-057442	Magnaporthe poae	38.49	4.00e-147	515.00
IUUC-Mmr-060806	Microcebus murinus	92.95	0.00e+00	1407.00
IUUC-Mpu-066762	Mustela putorius furo	92.72	0.00e+00	1413.00
IUUC-Mlu-066981	Myotis lucifugus	92.69	0.00e+00	1405.00
IUUC-Nle-069804	Nomascus leucogenys	91.30	0.00e+00	1409.00
IUUC-Opr-070591	Ochotona princeps	87.92	0.00e+00	1308.00
IUUC-Ocu-074913	Oryctolagus cuniculus	91.99	0.00e+00	1410.00
IUUC-Ola-086597	Oryzias latipes	90.48	0.00e+00	1395.00
IUUC-Oga-089116	Otolemur garnettii	89.45	0.00e+00	1347.00
IUUC-Oar-089366	Ovis aries	92.30	0.00e+00	1402.00
IUUC-Ptr-091382	Pan troglodytes	91.99	0.00e+00	1407.00
IUUC-Psi-093298	Pelodiscus sinensis	93.64	0.00e+00	1406.00
IUUC-Pfo-096071	Poecilia formosa	95.16	0.00e+00	1514.00
IUUC-Pab-098682	Pongo abelii	91.99	0.00e+00	1409.00
IUUC-Pva-102754	Pteropus vampyrus	91.86	0.00e+00	1370.00
IUUC-Rno-105600	Rattus norvegicus	92.07	0.00e+00	1207.00
IUUC-Sha-107144	Sarcophilus harrisii	92.30	0.00e+00	1294.00
IUUC-Sar-113122	Sorex araneus	82.36	0.00e+00	1195.00
IUUC-Tme-126897	Tuber melanosporum	39.05	3.00e-152	532.00
IUUC-Tbe-127371	Tupaia belangeri	83.33	0.00e+00	1123.00
IUUC-Ttr-129305	Tursiops truncatus	86.51	0.00e+00	1212.00
IUUC-Vpa-130591	Vicugna pacos	83.31	0.00e+00	1219.00
IUUC-Xtr-132979	Xenopus tropicalis	74.87	0.00e+00	1070.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence