iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000013582.1	ENSOART00000014777.1	ENSOARP00000014563.1
ENSOARG00000013582.1	ENSOART00000014778.1	ENSOARP00000014564.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.20e-54	184.0	8	137
UBD/UBC-like/UBD_UBC	5.60e-77	256.7	8	136

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 3    kkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeek 91
           +kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+tki+hPn+++nG++Cl+il+  ++
   Q: 8    YKELTDLQRDPPAQCSAGPVGD-DLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVVFTTKIYHPNINSNGSICLDILR--SQ 93
           69********************.9************************************************************9..** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykk 135
           Wspal+v++vllsi+sll++pnp++pl  e+a+++k++re+y +
   Q: 94   WSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYVS 137
           *****************************************975 PP

UBD/UBC-like/UBD_UBC

   S: 3    kkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsa 91
            kel dl+rd++aq+sa++v+ddlf+++ati+gp+dspy+ggvfflti++ptdypfkppkv f+tkiyhpninsngsicldilrsqws+
   Q: 8    YKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVVFTTKIYHPNINSNGSICLDILRSQWSP 96
           59*************************************************************************************** PP
   S: 92   altlskvllslcslladaepddplvaeiariyktdkekyk 131
           alt+skvlls+csll+d++pddplv+eia+ yk+d+eky 
   Q: 97   ALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYV 136
           **************************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MISMPRDYKE LTDLQRDPPA QCSAGPVGDD LFHWQATIMG PNDSPYQGGV FFLTIHFPTD 60
YPFKPPKVVF TTKIYHPNIN SNGSICLDIL RSQWSPALTV SKVLLSICSL LCDPNPDDPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATCAGCA TGCCCAGAGA TTACAAAGTG GGATCAGGAG GTTCTTTGTG GATGAGCTGA 60
GTTTCAAGCA TTGTTCAGGT AAGGAGGAAT GTGATCAGCT AGATTTAAAC TTCATACATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012632	Bos taurus	94.00	1.00e-81	294.00
IUUC-Itr-047868	Ictidomys tridecemlineatus	92.75	8.00e-73	265.00
IUUC-Oga-089011	Otolemur garnettii	90.97	1.00e-74	271.00
IUUC-Tru-118588	Takifugu rubripes	87.07	2.00e-74	270.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence