iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073679

UUCD1 version

UUC-OrA-00407

Ensembl Protein ID

ENSOANP00000020410.1

UniProt Accession

F7AY66; F7AY66_ORNAN

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000012904.2	ENSOANT00000020413.1	ENSOANP00000020410.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-64	217.4	562	800

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
            dl++rl+v f gEegld+gGv+++ ++  +++      +l + s + + ++++  ++     ++ +  +   r  + al++g+++d+ 
   Q: 562  PDLRRRLWVIFPGEEGLDYGGVASNRYWHSCAR-----GPLITPSGKARVSRRVLAAAV-RRRDRARAPHRPARRPASALFHGKFIDTG 644
           6899************************99986.....356778888888888777775.5669999999999**************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +s +fyk++l+k++ ++dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k++eLkp+G+ni Vt++NkeeY++ v+e+
   Q: 645  FSLPFYKRILNKPVGIKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHELKPDGSNILVTEANKEEYIRMVAEW 730
           **********************************99...9************************************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwe 251
           rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw+
   Q: 731  RLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAVYRH-YTRTSKQIAWFWQ 800
           *******************************************************99.************7 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MTSGAARPGT APGLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVSVDGQ SKKTDKCSNT 60
SSPKWKQPLT VIVTPVSKLS FRVWSHQTLK SDISLGSAVL DIQETLKSNN MKLDEVVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGAGCG GTGCGGCGCG ACCGGGGACG GCGCCCGGAC TGACCATGAA ATCCCAACTG 60
CAGATCACGG GTAGGTCACC GGGCAGGGGC TTCCGGACGA TTCCGTGAGC GAGCGAGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cfa-020648	Canis familiaris	66.87	0.00e+00	965.00
IUUC-Eca-033793	Equus caballus	66.55	0.00e+00	978.00
IUUC-Fca-035605	Felis catus	67.49	0.00e+00	989.00
IUUC-Hsa-046564	Homo sapiens	67.92	0.00e+00	1001.00
IUUC-Mmr-061135	Microcebus murinus	66.59	0.00e+00	993.00
IUUC-Mdo-062505	Monodelphis domestica	67.84	0.00e+00	1006.00
IUUC-Oga-088167	Otolemur garnettii	65.85	0.00e+00	966.00
IUUC-Ptr-090819	Pan troglodytes	66.38	0.00e+00	959.00
IUUC-Pab-097580	Pongo abelii	67.61	0.00e+00	995.00
IUUC-Sha-107175	Sarcophilus harrisii	67.68	0.00e+00	1006.00
IUUC-Tgu-116632	Taeniopygia guttata	66.13	0.00e+00	950.00
IUUC-Tsy-119198	Tarsius syrichta	65.33	0.00e+00	972.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence