iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tae-125344

Ensembl Protein ID

TRIAE_CS42_6BL_TGACv1_500432_AA1604530.1

UniProt Accession

A0A1D6APM2; A0A1D6APM2_WHEAT

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIAE_CS42_6BL_TGACv1_500432_AA1604530	TRIAE_CS42_6BL_TGACv1_500432_AA1604530.1	TRIAE_CS42_6BL_TGACv1_500432_AA1604530.1
TRIAE_CS42_6BL_TGACv1_500432_AA1604530	TRIAE_CS42_6BL_TGACv1_500432_AA1604530.2	TRIAE_CS42_6BL_TGACv1_500432_AA1604530.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	3.10e-66	226.7	12	323

Active Site

Position(s)	Description	Evidence
83	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
158	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 16   glftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdedi 84
           g+ft+l+++  vk++ qveelysLd ++l+++ +pv+gl++lFk+ +  + +r          vv  d 
   Q: 12   GVFTELIQEMQVKGV-QVEELYSLDVDSLSQL-QPVYGLIFLFKWMPGGNDERP---------VV-SDP 68
           79*************.****************.9*************9999993.........33.566 PP
   S: 85   iktiffakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihns 153
             ++ffa qvi N+Cat+A+ls l n  +   d+G++ls+lke+t a+ p++k+la++n++ ++++hns
   Q: 69   NPNLFFARQVITNACATQAILSILMNRPEI--DIGPELSNLKEFTGAFAPDMKGLAINNSDSIRAAHNS 135
           78************************9998..************************************* PP
   S: 154  lariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkk...keteelkdklkvv 219
           +ar+e++ ++e++++++   ++e++hf+sy++ +g lyeldglk+ P+ lg+     ++  + + ++ v
   Q: 136  FARPEPFVSDEQKAATK---DDEVYHFISYIPFEGVLYELDGLKEGPISLGQYtggPQDLGWLQMVQPV 201
           **********9997665...9*******************************944346778******** PP
   S: 220  raflerikllesdeirfnllaivadrrviktlrlnvlkid..................keLlkLlkdie 270
           +   eri+ +++ eirfnl+ai ++r+ ++t+ l+ l+                    + L   l ++ 
   Q: 202  I--QERIERYSQSEIRFNLMAIIKNRKDVYTAELKELEKKreqilqelsneataaaekEPLNGALAEVA 268
           *..******************************988877799***************6668899***** PP
   S: 271  seeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             +e   ++++ e++k +k+k ++ rR++ny  f++ ++k la++++l  lve+ 
   Q: 269  LAVEAVGEKIAMEEDKFRKWKTENVRRKHNYIPFLFNLLKALAEKKQLTPLVEKA 323
           ****************************************************983 PP

Organism

Triticum aestivum

Protein Sequence
(Fasta)

MNIFDQSLCF VGVFTELIQE MQVKGVQVEE LYSLDVDSLS QLQPVYGLIF LFKWMPGGND 60
ERPVVSDPNP NLFFARQVIT NACATQAILS ILMNRPEIDI GPELSNLKEF TGAFAPDMKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCGGATCA GCTCGATCGA CCCACGCATC CACCCCCTTC TTCAAGCCTC CCCCGCCCCT 60
CCCCCTCTGC TACCTAGGTC TCGTCTCGTC AGCACGCCCG CGCCGCCGCC CCCTCCCGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0005622--C:intracellular
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cho-024928	Choloepus hoffmanni	52.70	3.00e-16	79.30
IUUC-Eca-033776	Equus caballus	46.73	5.00e-74	271.00
IUUC-Fal-037597	Ficedula albicollis	46.08	2.00e-70	259.00
IUUC-Mga-060178	Meleagris gallopavo	46.33	1.00e-75	276.00
IUUC-Opr-070628	Ochotona princeps	42.57	3.00e-71	262.00
IUUC-Oan-073004	Ornithorhynchus anatinus	50.00	9.00e-60	223.00
IUUC-Rno-105579	Rattus norvegicus	41.64	3.00e-70	259.00
IUUC-Ssc-115501	Sus scrofa	46.52	2.00e-76	279.00
IUUC-Tbe-127619	Tupaia belangeri	41.50	2.00e-55	209.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence