iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059334

UUCD1 version

UUC-MeG-00477

Ensembl Protein ID

ENSMGAP00000010699.1

UniProt Accession

G1ND16; G1ND16_MELGA

Protein Name

Uncharacterized protein

Gene Name

TRIM8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000010315.1	ENSMGAT00000011560.1	ENSMGAP00000010699.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	6.80e-08	32.7	15	56
E3 activity/RING/U-box	3.50e-06	26.7	11	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl  f + p+ lpC+H f++ C+ ++w     ++ +  rCP C+
   Q: 15   CPICLHVFVE-PVQLPCKHNFCRGCIgEAW----AKETGLVRCPECN 56
           ********99.999****************....88**********7 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqawce 70
           ee++CpI l ++ +Pv lp+ + + r +I e w ++ g   cP ++q   ++ +l  nl l ++++++ +
   Q: 11   EELICPICLHVFVEPVQLPCKHNFCRGCIgEAWAKETGLvRCPECNQAYnQKPNLEKNLKLTNIVEKFNS 80
           799**************************67787666668*********666677999999999998865 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKETGLV RCPECNQAYN 60
QKPNLEKNLK LTNIVEKFNS LNLEKPPSVL HCVFCRRGPP LPAQKICLRC EAPCCQSHVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGAGA ACTGGAAGAA CTGTTTCGAG GAGGAGCTCA TCTGCCCCAT CTGCCTGCAC 60
GTCTTCGTGG AGCCCGTCCA GCTCCCCTGC AAGCACAACT TCTGCCGGGG CTGCATCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016605--C:PML body
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0019827--P:stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001258	Ailuropoda melanoleuca	86.23	0.00e+00	1007.00
IUUC-Apl-004223	Anas platyrhynchos	99.09	0.00e+00	1100.00
IUUC-Aca-005106	Anolis carolinensis	96.01	0.00e+00	1107.00
IUUC-Ame-011348	Astyanax mexicanus	68.37	0.00e+00	780.00
IUUC-Bta-012787	Bos taurus	86.39	0.00e+00	1012.00
IUUC-Cja-019471	Callithrix jacchus	85.84	0.00e+00	1006.00
IUUC-Cfa-020052	Canis familiaris	86.39	0.00e+00	1011.00
IUUC-Cpo-022491	Cavia porcellus	82.09	1.00e-180	624.00
IUUC-Csa-023544	Chlorocebus sabaeus	86.21	0.00e+00	1010.00
IUUC-Dre-028013	Danio rerio	67.43	0.00e+00	768.00
IUUC-Dno-029676	Dasypus novemcinctus	86.21	0.00e+00	1012.00
IUUC-Dor-030402	Dipodomys ordii	85.66	0.00e+00	1004.00
IUUC-Ete-033188	Echinops telfairi	77.94	0.00e+00	902.00
IUUC-Eca-033524	Equus caballus	85.87	0.00e+00	999.00
IUUC-Eeu-034979	Erinaceus europaeus	80.88	4.00e-118	417.00
IUUC-Fca-036362	Felis catus	86.39	0.00e+00	1010.00
IUUC-Fal-036652	Ficedula albicollis	97.85	0.00e+00	1084.00
IUUC-Gmo-039405	Gadus morhua	60.04	0.00e+00	640.00
IUUC-Gga-040813	Gallus gallus	99.64	0.00e+00	1108.00
IUUC-Gac-041792	Gasterosteus aculeatus	63.06	0.00e+00	650.00
IUUC-Ggo-044962	Gorilla gorilla	85.84	0.00e+00	1006.00
IUUC-Hsa-046158	Homo sapiens	85.66	0.00e+00	1003.00
IUUC-Itr-048118	Ictidomys tridecemlineatus	86.03	0.00e+00	1008.00
IUUC-Lch-049433	Latimeria chalumnae	84.29	0.00e+00	913.00
IUUC-Loc-052026	Lepisosteus oculatus	78.28	0.00e+00	895.00
IUUC-Laf-054159	Loxodonta africana	82.72	0.00e+00	797.00
IUUC-Mcc-055490	Macaca mulatta	86.21	0.00e+00	1010.00
IUUC-Meu-056549	Macropus eugenii	85.82	0.00e+00	706.00
IUUC-Mmr-061672	Microcebus murinus	86.57	0.00e+00	1014.00
IUUC-Mdo-061849	Monodelphis domestica	86.72	0.00e+00	898.00
IUUC-Mmu-063537	Mus musculus	85.84	0.00e+00	1005.00
IUUC-Mpu-065762	Mustela putorius furo	86.57	0.00e+00	1014.00
IUUC-Mlu-066979	Myotis lucifugus	80.41	0.00e+00	652.00
IUUC-Nle-069419	Nomascus leucogenys	85.84	0.00e+00	1006.00
IUUC-Opr-070981	Ochotona princeps	86.03	0.00e+00	1010.00
IUUC-Ont-072053	Oreochromis niloticus	58.70	1.00e-175	608.00
IUUC-Oan-073608	Ornithorhynchus anatinus	92.94	0.00e+00	877.00
IUUC-Ocu-074694	Oryctolagus cuniculus	86.75	0.00e+00	985.00
IUUC-Ola-086949	Oryzias latipes	66.49	3.00e-146	511.00
IUUC-Olu-087666	Ostreococcus lucimarinus	35.44	3.00e-09	56.20
IUUC-Oga-089175	Otolemur garnettii	86.03	0.00e+00	1010.00
IUUC-Oar-089591	Ovis aries	77.58	0.00e+00	794.00
IUUC-Ptr-091309	Pan troglodytes	84.75	0.00e+00	972.00
IUUC-Pan-091903	Papio anubis	86.21	0.00e+00	1010.00
IUUC-Psi-093293	Pelodiscus sinensis	95.50	0.00e+00	1065.00
IUUC-Pfo-097191	Poecilia formosa	59.62	6.00e-173	600.00
IUUC-Pab-098251	Pongo abelii	82.40	0.00e+00	956.00
IUUC-Pca-100504	Procavia capensis	86.03	0.00e+00	1009.00
IUUC-Pva-102320	Pteropus vampyrus	85.84	0.00e+00	975.00
IUUC-Rno-105545	Rattus norvegicus	85.84	0.00e+00	1005.00
IUUC-Ssc-116121	Sus scrofa	86.39	0.00e+00	1012.00
IUUC-Tgu-116724	Taeniopygia guttata	98.91	0.00e+00	1096.00
IUUC-Tru-118048	Takifugu rubripes	58.33	6.00e-180	623.00
IUUC-Tni-120856	Tetraodon nigroviridis	59.36	3.00e-170	591.00
IUUC-Tbe-127400	Tupaia belangeri	70.83	2.00e-140	491.00
IUUC-Ttr-128233	Tursiops truncatus	85.48	0.00e+00	988.00
IUUC-Xtr-132578	Xenopus tropicalis	92.38	0.00e+00	1043.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence