iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091309

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03073967

Gene Name

TRIM8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000002896.5	ENSPTRT00000005517.5	ENSPTRP00000005103.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.10e-07	32.3	15	56
E3 activity/RING/U-box	1.00e-05	25.5	11	78

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCl  f + p+ lpC+H f++ C+ ++w     + s+  rCP C+
   Q: 15   CPICLHVFVE-PVQLPCKHNFCRGCIgEAW----AKDSGLVRCPECN 56
           ********99.999****************....889*********7 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssI.ekwlasggk.tcPvtrqpl.teedlvPnltlrrliqaw 68
           ee++CpI l ++ +Pv lp+ + + r +I e w +++g   cP ++q   ++  l  nl l ++++++
   Q: 11   EELICPICLHVFVEPVQLPCKHNFCRGCIgEAWAKDSGLvRCPECNQAYnQKPGLEKNLKLTNIVEKF 78
           799**************************66788555557*******994455668888888888877 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAENWKNCFE EELICPICLH VFVEPVQLPC KHNFCRGCIG EAWAKDSGLV RCPECNQAYN 60
QKPGLEKNLK LTNIVEKFNA LHVEKPPAAL HCVFCRRGPP LPAQKVCLRC EAPCCQSHVQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGACCGT CGGGGCCGGC TGGGGCCGGA GCTCGGGGCT CGGTGGGCCT ACAGCGGCTC 60
CGGACGGACC CCCGGGGCTG GGGAGTCGGG GAGGCCTGCC CCGGCCCCCT GCCCGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0016605--C:PML body
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0019827--P:stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001258	Ailuropoda melanoleuca	97.64	0.00e+00	1090.00
IUUC-Apl-004223	Anas platyrhynchos	84.78	0.00e+00	954.00
IUUC-Aca-005106	Anolis carolinensis	84.75	0.00e+00	980.00
IUUC-Ame-011348	Astyanax mexicanus	66.43	0.00e+00	730.00
IUUC-Bta-012787	Bos taurus	98.37	0.00e+00	1099.00
IUUC-Cja-019471	Callithrix jacchus	98.55	0.00e+00	1101.00
IUUC-Cfa-020052	Canis familiaris	97.82	0.00e+00	1094.00
IUUC-Cpo-022491	Cavia porcellus	95.82	0.00e+00	688.00
IUUC-Csa-023544	Chlorocebus sabaeus	98.55	0.00e+00	1101.00
IUUC-Dre-027445	Danio rerio	64.63	0.00e+00	716.00
IUUC-Dno-029676	Dasypus novemcinctus	97.64	0.00e+00	1095.00
IUUC-Dor-030402	Dipodomys ordii	96.91	0.00e+00	1086.00
IUUC-Ete-033188	Echinops telfairi	90.05	0.00e+00	1015.00
IUUC-Eca-033524	Equus caballus	97.28	0.00e+00	1087.00
IUUC-Eeu-034979	Erinaceus europaeus	97.61	4.00e-143	501.00
IUUC-Fca-036362	Felis catus	97.82	0.00e+00	1093.00
IUUC-Fal-036652	Ficedula albicollis	83.36	0.00e+00	936.00
IUUC-Gmo-039405	Gadus morhua	59.93	2.00e-178	618.00
IUUC-Gga-040813	Gallus gallus	84.57	0.00e+00	956.00
IUUC-Gac-041792	Gasterosteus aculeatus	61.70	0.00e+00	643.00
IUUC-Ggo-044962	Gorilla gorilla	98.91	0.00e+00	1105.00
IUUC-Hsa-046158	Homo sapiens	98.73	0.00e+00	1103.00
IUUC-Itr-048118	Ictidomys tridecemlineatus	98.00	0.00e+00	1095.00
IUUC-Lch-049433	Latimeria chalumnae	79.11	0.00e+00	842.00
IUUC-Loc-052026	Lepisosteus oculatus	75.58	0.00e+00	845.00
IUUC-Laf-054159	Loxodonta africana	95.25	0.00e+00	874.00
IUUC-Mcc-055490	Macaca mulatta	98.55	0.00e+00	1101.00
IUUC-Meu-056549	Macropus eugenii	87.78	0.00e+00	708.00
IUUC-Mga-059334	Meleagris gallopavo	84.75	0.00e+00	951.00
IUUC-Mmr-061672	Microcebus murinus	98.19	0.00e+00	1097.00
IUUC-Mdo-061849	Monodelphis domestica	88.33	0.00e+00	899.00
IUUC-Mmu-063537	Mus musculus	96.73	0.00e+00	1083.00
IUUC-Mpu-065762	Mustela putorius furo	98.00	0.00e+00	1096.00
IUUC-Mlu-066979	Myotis lucifugus	93.81	0.00e+00	717.00
IUUC-Nle-069419	Nomascus leucogenys	98.91	0.00e+00	1105.00
IUUC-Opr-070981	Ochotona princeps	97.28	0.00e+00	1090.00
IUUC-Ont-072053	Oreochromis niloticus	56.48	5.00e-171	593.00
IUUC-Oan-073608	Ornithorhynchus anatinus	85.65	0.00e+00	798.00
IUUC-Ocu-074694	Oryctolagus cuniculus	97.28	0.00e+00	1048.00
IUUC-Ola-086949	Oryzias latipes	57.94	3.00e-171	594.00
IUUC-Oga-089175	Otolemur garnettii	98.37	0.00e+00	1099.00
IUUC-Oar-089591	Ovis aries	87.91	0.00e+00	855.00
IUUC-Pan-091903	Papio anubis	98.55	0.00e+00	1101.00
IUUC-Psi-093293	Pelodiscus sinensis	82.88	0.00e+00	937.00
IUUC-Pfo-097191	Poecilia formosa	57.69	2.00e-168	585.00
IUUC-Pab-098251	Pongo abelii	96.70	0.00e+00	1077.00
IUUC-Pca-100504	Procavia capensis	97.82	0.00e+00	1095.00
IUUC-Pva-102320	Pteropus vampyrus	96.91	0.00e+00	1043.00
IUUC-Rno-105545	Rattus norvegicus	96.91	0.00e+00	1083.00
IUUC-Ssc-116121	Sus scrofa	98.37	0.00e+00	1099.00
IUUC-Tgu-116724	Taeniopygia guttata	84.57	0.00e+00	951.00
IUUC-Tru-118048	Takifugu rubripes	57.29	1.00e-174	606.00
IUUC-Tni-120856	Tetraodon nigroviridis	58.01	9.00e-166	576.00
IUUC-Tbe-127400	Tupaia belangeri	84.21	5.00e-157	546.00
IUUC-Ttr-128233	Tursiops truncatus	97.46	0.00e+00	1076.00
IUUC-Xtr-132578	Xenopus tropicalis	83.12	0.00e+00	934.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence