iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091216

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03029923

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000016273.3	ENSPTRT00000030280.3	ENSPTRP00000027950.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-90	303.7	637	958

Active Site

Position(s)	Description	Evidence
928	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+k+l+v+f+gE g dlgGv++ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ +l
   Q: 637  NEDLRKELWVSFSGEIGYDLGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCNVANL 720
           689********************************************************9....567888.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p+l k+l+ +++ + ++ e       f ++ ++  ++++++L+p+G++i V+++Nk++Yv+++++
   Q: 721  PFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNFE-----EVFYIHFNVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYIN 804
           ***********************************87544444.....455555667779999************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G++++d+++++k++ y+ gy++++p+i +Fw+++++++ ee+k+fL F+
   Q: 805  YIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGNTDYDWKTFEKNAHYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFL 893
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++rl ++ ++++k   f+++++ ++++ +++ TCf+ L LP+Ys++e+++e L+ Ai++++gF+
   Q: 894  TGTDRLEMKDLNNMK-ITFCCPESWNERDPIRALTCFSILFLPKYSTMETVEEALQEAINNSRGFG 958
           ***************.77999999****************************************96 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MERRSRRKSR RNGRSTAGKA AASQPAKSPG TQLWLFPSAA GLQRALLRRV EVTRQLCCSP 60
GRLAVLERGG AGVQVHQLLA GSGGARTPKG GELFAWGQNL HGQLGVGRKF PSTTTPQIVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCGGA GGTCGCGGAG GAAGTCGCGG CGCAACGGGC GCTCGACCGC GGGCAAGGCC 60
GCCGCGTCCC AGCCCGCGAA GTCTCCGGGC ACACAGCTCT GGCTCTTTCC CAGCGCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	70.56	0.00e+00	1427.00
IUUC-Bta-012422	Bos taurus	67.16	0.00e+00	1074.00
IUUC-Cja-018751	Callithrix jacchus	91.15	0.00e+00	1641.00
IUUC-Cfa-020247	Canis familiaris	78.21	0.00e+00	1418.00
IUUC-Csa-023204	Chlorocebus sabaeus	95.06	0.00e+00	1612.00
IUUC-Cho-025101	Choloepus hoffmanni	62.58	2.00e-177	616.00
IUUC-Dno-029795	Dasypus novemcinctus	71.12	0.00e+00	971.00
IUUC-Dor-030862	Dipodomys ordii	65.75	0.00e+00	1110.00
IUUC-Ete-032585	Echinops telfairi	59.58	0.00e+00	811.00
IUUC-Eca-034358	Equus caballus	75.86	0.00e+00	1335.00
IUUC-Eeu-035282	Erinaceus europaeus	65.75	0.00e+00	733.00
IUUC-Fca-036505	Felis catus	77.61	0.00e+00	1415.00
IUUC-Ggo-045445	Gorilla gorilla	95.17	0.00e+00	1615.00
IUUC-Hsa-046342	Homo sapiens	98.74	0.00e+00	1697.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	69.83	0.00e+00	1235.00
IUUC-Laf-053921	Loxodonta africana	73.36	0.00e+00	1308.00
IUUC-Mcc-054850	Macaca mulatta	95.06	0.00e+00	1618.00
IUUC-Mmr-060783	Microcebus murinus	65.64	0.00e+00	1101.00
IUUC-Mpu-066123	Mustela putorius furo	76.15	0.00e+00	1376.00
IUUC-Mlu-067914	Myotis lucifugus	75.98	0.00e+00	1326.00
IUUC-Nle-069986	Nomascus leucogenys	97.24	0.00e+00	1716.00
IUUC-Opr-070513	Ochotona princeps	68.79	0.00e+00	853.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.25	0.00e+00	1285.00
IUUC-Oga-088858	Otolemur garnettii	76.91	0.00e+00	692.00
IUUC-Oar-089456	Ovis aries	76.23	0.00e+00	1312.00
IUUC-Pan-091706	Papio anubis	85.49	0.00e+00	1638.00
IUUC-Pca-100320	Procavia capensis	67.05	0.00e+00	1202.00
IUUC-Pva-102646	Pteropus vampyrus	78.05	0.00e+00	1381.00
IUUC-Sar-113605	Sorex araneus	74.43	1.00e-137	483.00
IUUC-Tsy-119240	Tarsius syrichta	65.29	0.00e+00	1131.00
IUUC-Tbe-127787	Tupaia belangeri	70.46	0.00e+00	1248.00
IUUC-Ttr-128191	Tursiops truncatus	74.14	0.00e+00	1300.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence