iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010213.2	ENSOGAT00000032190.1	ENSOGAP00000017242.1
ENSOGAG00000010213.2	ENSOGAT00000010214.2	ENSOGAP00000009130.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	4.60e-61	207.0	2	251

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/UCH

   S: 7    ewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkine.............................kres 66
           ++ ++e +P+++++++ ++gv +++++ ++ +L++e+lg+++ p ++llllF+++                              ++e+
   Q: 2    QLKPMEINPEMLNKVLARLGVAGQWRFADVLGLEEESLGSVPAPACALLLLFPLTAqncfkfgreaafqlhhssqlvrlflvcfqEHEN 90
           5789************************************************************************************* PP
   S: 67   srksqvtsndlevvdediiktiffakqvigNsCatyAllsvllncedkl.ldlGttlsrlkestkaespenkalalgnqqvlecihnsl 154
           +rk+q++    e +++++  +++f+kq+igNsC+t++l+++++n+ dkl ++ G+ l++++++t+++spe++a++++++++++++h+++
   Q: 91   FRKKQIE----ELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNRDKLeFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAV 175
           *****99....99**************************************************************************** PP
   S: 155  ariesrseperqdedneqytkeafhfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaiva 243
           a++++++ +          +k +fhf+++ n++g+lyeldg++pfP+++g+++e+  l+d++kv+r+f+er    e++e+rf+++a+++
   Q: 176  AQEGQCRVD----------DKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDCLLQDAAKVCREFTER----EQGEVRFSAVALCK 250
           *******99..........5679************************************************....************98 PP
   S: 244  d 244
           +
   Q: 251  A 251
           7 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MQLKPMEINP EMLNKVLARL GVAGQWRFAD VLGLEEESLG SVPAPACALL LLFPLTAQNC 60
FKFGREAAFQ LHHSSQLVRL FLVCFQEHEN FRKKQIEELK GQEVSPKVYF MKQTIGNSCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTTGCGAA GATGCAGCTT AAACCGATGG AGATTAACCC CGAGGTGAGC GCCAGGTGCA 60
CCGTGGCCCA GAGAGCGCAA GGCTGAGGGG CAGGCCTCGC CAGGTGGCCA TATCGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR030297--UCHL1

PROSITE

PS00140--UCH_1

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043209--C:myelin sheath
GO:0044306--C:neuron projection terminus
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0016874--F:ligase activity
GO:0008242--F:omega peptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007628--P:adult walking behavior
GO:0007412--P:axon target recognition
GO:0019896--P:axonal transport of mitochondrion
GO:0008283--P:cell proliferation
GO:0042755--P:eating behavior
GO:0048747--P:muscle fiber development
GO:0043407--P:negative regulation of MAP kinase activity
GO:0050905--P:neuromuscular process
GO:0016579--P:protein deubiquitination
GO:0002931--P:response to ischemia
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001376	Ailuropoda melanoleuca	88.67	8.00e-119	419.00
IUUC-Apl-003693	Anas platyrhynchos	62.06	2.00e-87	314.00
IUUC-Aca-004716	Anolis carolinensis	66.80	5.00e-96	343.00
IUUC-Ame-011806	Astyanax mexicanus	59.13	4.00e-80	290.00
IUUC-Bta-013521	Bos taurus	91.27	7.00e-126	442.00
IUUC-Cja-018752	Callithrix jacchus	85.77	1.00e-112	398.00
IUUC-Cfa-020442	Canis familiaris	85.77	8.00e-113	399.00
IUUC-Cpo-021723	Cavia porcellus	98.19	6.00e-95	339.00
IUUC-Csa-023626	Chlorocebus sabaeus	86.11	2.00e-113	400.00
IUUC-Cho-024548	Choloepus hoffmanni	67.88	2.00e-36	144.00
IUUC-Dre-027854	Danio rerio	57.31	6.00e-79	286.00
IUUC-Dno-029325	Dasypus novemcinctus	85.71	6.00e-114	402.00
IUUC-Dor-030114	Dipodomys ordii	84.13	5.00e-122	429.00
IUUC-Ete-033092	Echinops telfairi	95.76	8.00e-92	329.00
IUUC-Eca-033854	Equus caballus	97.18	1.00e-79	288.00
IUUC-Eeu-034493	Erinaceus europaeus	82.54	1.00e-108	385.00
IUUC-Fal-036693	Ficedula albicollis	64.02	7.00e-87	313.00
IUUC-Gmo-038848	Gadus morhua	53.94	4.00e-70	257.00
IUUC-Gga-041078	Gallus gallus	65.22	9.00e-96	342.00
IUUC-Gac-042064	Gasterosteus aculeatus	55.02	7.00e-74	269.00
IUUC-Ggo-044827	Gorilla gorilla	86.11	9.00e-114	402.00
IUUC-Hsa-045820	Homo sapiens	86.11	9.00e-114	402.00
IUUC-Itr-048496	Ictidomys tridecemlineatus	86.11	8.00e-114	402.00
IUUC-Lch-050121	Latimeria chalumnae	65.34	6.00e-93	333.00
IUUC-Loc-052342	Lepisosteus oculatus	61.96	9.00e-88	315.00
IUUC-Laf-053916	Loxodonta africana	83.86	4.00e-111	393.00
IUUC-Mcc-054838	Macaca mulatta	86.11	2.00e-113	400.00
IUUC-Meu-056478	Macropus eugenii	77.78	1.00e-114	405.00
IUUC-Mga-059878	Meleagris gallopavo	63.82	1.00e-89	322.00
IUUC-Mdo-062544	Monodelphis domestica	76.59	4.00e-103	367.00
IUUC-Mmu-063300	Mus musculus	85.71	1.00e-123	435.00
IUUC-Mpu-066128	Mustela putorius furo	84.28	8.00e-100	355.00
IUUC-Mlu-067778	Myotis lucifugus	83.73	4.00e-121	426.00
IUUC-Nle-069686	Nomascus leucogenys	86.11	1.00e-113	402.00
IUUC-Opr-070535	Ochotona princeps	96.97	4.00e-94	337.00
IUUC-Ont-071510	Oreochromis niloticus	54.98	6.00e-75	273.00
IUUC-Ocu-074590	Oryctolagus cuniculus	85.32	9.00e-114	402.00
IUUC-Oar-089861	Ovis aries	91.27	7.00e-126	442.00
IUUC-Ptr-091536	Pan troglodytes	84.52	2.00e-111	394.00
IUUC-Pan-092909	Papio anubis	86.11	2.00e-113	400.00
IUUC-Psi-093818	Pelodiscus sinensis	69.17	3.00e-98	350.00
IUUC-Pfo-097335	Poecilia formosa	52.36	2.00e-73	268.00
IUUC-Pab-098048	Pongo abelii	86.11	9.00e-114	402.00
IUUC-Pca-100818	Procavia capensis	63.39	2.00e-62	231.00
IUUC-Pva-102954	Pteropus vampyrus	84.52	1.00e-108	385.00
IUUC-Rno-105966	Rattus norvegicus	85.71	1.00e-123	435.00
IUUC-Sha-107111	Sarcophilus harrisii	86.06	1.00e-85	308.00
IUUC-Sar-113190	Sorex araneus	74.56	5.00e-38	148.00
IUUC-Ssc-115908	Sus scrofa	70.08	9.00e-95	338.00
IUUC-Tgu-117465	Taeniopygia guttata	60.42	1.00e-80	292.00
IUUC-Tru-118565	Takifugu rubripes	52.79	1.00e-64	239.00
IUUC-Tsy-119561	Tarsius syrichta	96.36	3.00e-92	330.00
IUUC-Tbe-128048	Tupaia belangeri	95.15	3.00e-92	329.00
IUUC-Ttr-128494	Tursiops truncatus	84.86	2.00e-110	391.00
IUUC-Vda-129850	Verticillium dahliae	31.76	3.00e-27	114.00
IUUC-Xtr-132286	Xenopus tropicalis	61.11	1.00e-86	311.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence