iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090634

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

G2/M-phase specific E3 ubiquitin protein ligase

Genbank Nucleotide ID

AACZ03095649

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000006234.4	ENSPTRT00000011434.4	ENSPTRP00000010578.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-43	147.7	388	696

Active Site

Position(s)	Description	Evidence
666	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 388  YAIEVAYVIENdnfGSEHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 467
           56788898887777***********************..45..677788888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      ++e++++  + g+ +   t ++k++ vk+++ y
   Q: 468  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATTVADLKSI-----INECYNYLELIGCLRLITTLSDKYMLVKDILGY 546
           ***********8...*************988888774..555555788765.....88999**99************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ +++++ +e+f++G++++  le+++++ e  +++l+++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + ++ ++  
   Q: 547  HVIQRVHTPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSE--LFTVHTLPDVKAL-GFWNSYlQAVEDGKSTTTMEdi 632
           ***************************************************..888899******8.8998765788777777666666 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg+s++P++Gf++ + ++ +++      ++P  n+C n+L +P  +++++++e++ ++i++t ++e
   Q: 633  liFATGCSSIPPAGFKPTP-SIECLHV-----DFPVGNKCNNCLAIPITNTYKEFQENMDFTIRNTLRLE 696
           66****************9.99****9.....********************************987665 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MNESKPGDSQ NLACVFCRKN DDCPNKYGEK KTKEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVNRASKLK CCVCKKNGAS IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACCGCTCTT TCCGGGTTTG CGAGCGGAAG TGGACGAATT TGAATCCTGT GGGCCGTTGA 60
ATGTGGCTGC TCGCGGTCGG CGTGCCCCGA CGTACAGCGG GCCGGGAAAA GTGGCACTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	91.50	0.00e+00	1364.00
IUUC-Apl-003763	Anas platyrhynchos	60.60	0.00e+00	857.00
IUUC-Aca-004328	Anolis carolinensis	60.81	0.00e+00	870.00
IUUC-Ame-011288	Astyanax mexicanus	40.28	7.00e-162	564.00
IUUC-Bta-012496	Bos taurus	86.79	0.00e+00	1291.00
IUUC-Cja-019756	Callithrix jacchus	94.60	0.00e+00	1389.00
IUUC-Cfa-020806	Canis familiaris	89.24	0.00e+00	1340.00
IUUC-Cpo-022519	Cavia porcellus	86.12	0.00e+00	1265.00
IUUC-Csa-023957	Chlorocebus sabaeus	97.88	0.00e+00	1442.00
IUUC-Cho-024375	Choloepus hoffmanni	83.12	0.00e+00	1189.00
IUUC-Cin-025325	Ciona intestinalis	40.88	2.00e-65	241.00
IUUC-Csv-026262	Ciona savignyi	43.01	3.00e-67	248.00
IUUC-Dre-027829	Danio rerio	40.62	5.00e-154	537.00
IUUC-Dno-029362	Dasypus novemcinctus	89.25	0.00e+00	1316.00
IUUC-Dor-030710	Dipodomys ordii	83.29	0.00e+00	1253.00
IUUC-Dse-031248	Dothistroma septosporum	40.38	3.00e-03	37.40
IUUC-Dme-031692	Drosophila melanogaster	35.21	4.00e-42	166.00
IUUC-Ete-032282	Echinops telfairi	80.99	0.00e+00	1164.00
IUUC-Eca-033963	Equus caballus	89.66	0.00e+00	1354.00
IUUC-Eeu-035029	Erinaceus europaeus	86.38	0.00e+00	1290.00
IUUC-Fca-036229	Felis catus	90.51	0.00e+00	1362.00
IUUC-Fal-037015	Ficedula albicollis	58.33	0.00e+00	872.00
IUUC-Gmo-039715	Gadus morhua	38.71	2.00e-75	275.00
IUUC-Gga-040298	Gallus gallus	59.03	0.00e+00	902.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.43	5.00e-143	501.00
IUUC-Ggo-045456	Gorilla gorilla	99.43	0.00e+00	1457.00
IUUC-Hsa-046297	Homo sapiens	99.58	0.00e+00	1465.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	88.47	0.00e+00	934.00
IUUC-Lch-050287	Latimeria chalumnae	67.32	3.00e-106	379.00
IUUC-Loc-052839	Lepisosteus oculatus	57.58	1.00e-31	128.00
IUUC-Laf-053581	Loxodonta africana	88.29	0.00e+00	1303.00
IUUC-Mcc-055615	Macaca mulatta	97.88	0.00e+00	1441.00
IUUC-Meu-056753	Macropus eugenii	49.29	1.00e-129	456.00
IUUC-Mga-059902	Meleagris gallopavo	59.24	0.00e+00	908.00
IUUC-Mmr-061522	Microcebus murinus	93.34	0.00e+00	1384.00
IUUC-Mdo-063022	Monodelphis domestica	66.02	0.00e+00	908.00
IUUC-Mmu-063609	Mus musculus	77.03	0.00e+00	1172.00
IUUC-Mpu-066656	Mustela putorius furo	89.80	0.00e+00	1354.00
IUUC-Mlu-067011	Myotis lucifugus	89.19	0.00e+00	1313.00
IUUC-Nle-069949	Nomascus leucogenys	98.87	0.00e+00	1452.00
IUUC-Opr-071224	Ochotona princeps	83.46	6.00e-133	468.00
IUUC-Ont-072174	Oreochromis niloticus	37.70	6.00e-139	488.00
IUUC-Oan-072712	Ornithorhynchus anatinus	68.44	0.00e+00	984.00
IUUC-Ocu-073776	Oryctolagus cuniculus	90.93	0.00e+00	1347.00
IUUC-Ola-087247	Oryzias latipes	36.96	1.00e-129	457.00
IUUC-Oga-088094	Otolemur garnettii	87.88	0.00e+00	1234.00
IUUC-Oar-090248	Ovis aries	86.51	0.00e+00	1283.00
IUUC-Pan-092876	Papio anubis	98.02	0.00e+00	1443.00
IUUC-Psi-093580	Pelodiscus sinensis	61.84	0.00e+00	887.00
IUUC-Pma-094295	Petromyzon marinus	53.97	4.00e-74	270.00
IUUC-Pfo-096351	Poecilia formosa	37.18	2.00e-144	506.00
IUUC-Pab-097596	Pongo abelii	99.01	0.00e+00	1456.00
IUUC-Pca-100309	Procavia capensis	82.01	0.00e+00	1218.00
IUUC-Pva-102526	Pteropus vampyrus	91.78	0.00e+00	857.00
IUUC-Rno-105432	Rattus norvegicus	82.10	0.00e+00	1227.00
IUUC-Sha-107089	Sarcophilus harrisii	65.37	0.00e+00	1012.00
IUUC-Sar-113667	Sorex araneus	69.03	0.00e+00	976.00
IUUC-Ssc-116200	Sus scrofa	89.38	0.00e+00	1338.00
IUUC-Tgu-116467	Taeniopygia guttata	58.10	0.00e+00	853.00
IUUC-Tru-117690	Takifugu rubripes	38.12	4.00e-153	535.00
IUUC-Tsy-119481	Tarsius syrichta	87.80	0.00e+00	919.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.27	5.00e-135	474.00
IUUC-Tbe-127241	Tupaia belangeri	82.10	0.00e+00	1165.00
IUUC-Ttr-129057	Tursiops truncatus	81.16	0.00e+00	1160.00
IUUC-Vpa-130685	Vicugna pacos	87.77	0.00e+00	1269.00
IUUC-Xtr-132555	Xenopus tropicalis	52.96	0.00e+00	753.00
IUUC-Xma-133723	Xiphophorus maculatus	50.91	1.00e-81	296.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence