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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046406
UUCD1 version UUC-HoS-00124
Ensembl Protein ID ENSP00000265348.3
UniProt Accession Q14999; B4DYZ0; F5H0L1; Q5T654; CUL7_HUMAN
Genbank Protein ID BAA07551.2; BAG63902.1; CAI13779.1; CAI13779.1; CAI19793.1; CAI19793.1; AAH33647.1
Protein Name Cullin-7
Genbank Nucleotide ID D38548; AK302668; AL355385; AL136304; AL136304; AL355385; BC033647
Gene Name CUL7; KIAA0076
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000044090.8 ENST00000265348.7 ENSP00000265348.3
ENSG00000044090.8 ENST00000535468.1 ENSP00000438788.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarOMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 17332328
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 1.80e-151 507.6 971 1519
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLsln 159
            ++W+ freql++++++f      y+++           +++w+++++ed +++ll+l+++l+ a+R+++++++r+l++++++       
   Q: 971  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDMAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA------- 1035
           589***************......****...........***********.********************************....... PP
   S: 160  klaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallr 248
            +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea +n++++  a++++++++t+Ll++ve+++++       +++va++r
   Q: 1036 -QALGKTCWEALVSPVVQNITSPDEDGISPLgWLLDQYLECQEAVFNPQSRGPAFFSRVRRLTHLLVHVEPCEAP-------PPVVATPR 1117
           .**************************************************************************.......******** PP
   S: 249  dkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetf 336
            k++++ +++++L++r+l+  ++++l++++++++++q++++lt++++++d   +V+r++e++n lq+++se+F+++a+Fl al+++++ +
   Q: 1118 PKGRNRSHDWSSLATRGLPssIMRNLTRCWRAVVEKQVNNFLTSSWRDDD---FVPRYCEHFNILQNSSSELFGPRAAFLLALQNGCAGA 1204
           ******************999*****************************...************************************* PP
   S: 337  vnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksasseaEesviekL 422
           ++k ++lkaa+++E++Ar+iDq++++s ++g++e+e +aql+++l+++ ++s++++   Fe+yY++++a+RLl   ++ss++E++v+e++
   Q: 1205 LLKLPFLKAAHVSEQFARHIDQQIQGSrIGGAQEMERLAQLQQCLQAVLIFSGLEIattFEHYYQHYMADRLLG--VVSSWLEGAVLEQI 1292
           **************************************************************************..************** PP
   S: 423  keecgaeftskL.erMfqdlkvSedlnrqFk........................................................eek 455
               g++f+++L ++M+q+l++S++l+rqF+                                                        e++
   Q: 1293 ----GPCFPNRLpQQMLQSLSTSKELQRQFHvyqlqqldqellkledtekkiqvglgasgkehksekeeeagaaavvdvaegeeeeeENE 1378
           ....*********************************************************************************98889 PP
   S: 456  enteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqhtlgraelkaelkkgkyel 533
           + ++e +++e+svlvLs+++Wp+a  ++t  ++++LP++l+ t++++++fY        le++s+R+LqW++ lg+ael++    g+++l
   Q: 1379 DLYYEGAMPEVSVLVLSRHSWPVAsiCHTlnPRTCLPSYLRGTLNRYSNFYnksqshpaLERGSQRRLQWTW-LGWAELQF----GNQTL 1463
           999*********************9999899*****************************************.********....***** PP
   S: 534  qVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqvlkkep 587
           +Vst+Qm++LL++n+ ++vsve+l + ++l++++L++++++L+ss+   +++++++
   Q: 1464 HVSTVQMWLLLYLNDLKAVSVESLLAFSGLSADMLNQAIGPLTSSRgpLDLHEQKD 1519
           ********************************************997777776655 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.
 Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development (PubMed:20139075). Does not promote polyubiquitination and proteasomal degradation of p53/TP53 (PubMed:16547496, PubMed:17332328). While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions.
Protein Sequence
(Fasta)
MVGELRYREF RVPLGPGLHA YPDELIRQRV GHDGHPEYQI RWLILRRGDE GDGGSGQVDC 60
KAEHILLWMS KDEIYANCHK MLGEDGQVIG PSQESAGEVG ALDKSVLEEM ETDVKSLIQR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046406|E3,Cullin|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGAGGTGCT GCGTCGCCAA GGTGGCATCC TCGGCTCCGC CCCGGCGCTC TCCCAGGGCC 60
CCTAGCTTTC CGCTGGGTCG GGCGGAAATG AGCCGTGGCT TTTGGCTGGC GGAGCCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046406|E3,Cullin|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0242--Dwarfism
KW-0333--Golgi apparatus
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50069--CULLIN_2
PS51284--DOC
Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8
SMART

SM01337--APC10
SM00884--Cullin_Nedd8
Gene Ontology

GO:1990393--C:3M complex
GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0007030--P:Golgi organization
GO:0036498--P:IRE1-mediated unfolded protein response
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0006508--P:proteolysis
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis
GO:0016032--P:viral process
KEGG hsa:9820
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002360 Ailuropoda melanoleuca 86.44 0.00e+00 2725.00
IUUC-Bta-013285 Bos taurus 84.39 0.00e+00 2727.00
IUUC-Cja-019033 Callithrix jacchus 91.34 0.00e+00 2898.00
IUUC-Cfa-020695 Canis familiaris 86.00 0.00e+00 1702.00
IUUC-Cpo-021513 Cavia porcellus 78.81 0.00e+00 2465.00
IUUC-Csa-023798 Chlorocebus sabaeus 96.88 0.00e+00 3034.00
IUUC-Dno-029587 Dasypus novemcinctus 80.93 0.00e+00 1469.00
IUUC-Dor-030234 Dipodomys ordii 83.78 0.00e+00 2741.00
IUUC-Ete-032612 Echinops telfairi 77.06 0.00e+00 870.00
IUUC-Eca-033408 Equus caballus 88.49 0.00e+00 2737.00
IUUC-Fca-035483 Felis catus 86.44 0.00e+00 2733.00
IUUC-Gac-041628 Gasterosteus aculeatus 48.59 0.00e+00 1170.00
IUUC-Ggo-044721 Gorilla gorilla 99.12 0.00e+00 3074.00
IUUC-Itr-048525 Ictidomys tridecemlineatus 87.64 0.00e+00 2727.00
IUUC-Lch-049956 Latimeria chalumnae 44.11 0.00e+00 1056.00
IUUC-Laf-054068 Loxodonta africana 85.27 0.00e+00 2746.00
IUUC-Mcc-055464 Macaca mulatta 97.00 0.00e+00 3030.00
IUUC-Meu-056198 Macropus eugenii 57.29 0.00e+00 1325.00
IUUC-Mmr-061464 Microcebus murinus 88.64 0.00e+00 2757.00
IUUC-Mdo-062018 Monodelphis domestica 59.31 0.00e+00 1394.00
IUUC-Mmu-063413 Mus musculus 76.74 0.00e+00 2367.00
IUUC-Mpu-066146 Mustela putorius furo 87.51 0.00e+00 2674.00
IUUC-Mlu-067036 Myotis lucifugus 84.50 0.00e+00 2715.00
IUUC-Opr-070670 Ochotona princeps 77.81 0.00e+00 2423.00
IUUC-Oan-073451 Ornithorhynchus anatinus 50.92 0.00e+00 1169.00
IUUC-Ocu-074155 Oryctolagus cuniculus 85.17 0.00e+00 2668.00
IUUC-Oga-089084 Otolemur garnettii 88.22 0.00e+00 2845.00
IUUC-Oar-090029 Ovis aries 86.01 0.00e+00 2737.00
IUUC-Ptr-091282 Pan troglodytes 97.69 0.00e+00 3116.00
IUUC-Pan-091883 Papio anubis 97.17 0.00e+00 3059.00
IUUC-Pab-098383 Pongo abelii 94.74 0.00e+00 2999.00
IUUC-Pca-100519 Procavia capensis 76.36 0.00e+00 844.00
IUUC-Pva-102417 Pteropus vampyrus 84.80 0.00e+00 2213.00
IUUC-Rno-105962 Rattus norvegicus 79.20 0.00e+00 2486.00
IUUC-Sar-113750 Sorex araneus 82.48 1.00e-174 607.00
IUUC-Ssc-115899 Sus scrofa 80.97 0.00e+00 2433.00
IUUC-Tsy-118860 Tarsius syrichta 85.01 0.00e+00 1117.00
IUUC-Tbe-127660 Tupaia belangeri 87.42 0.00e+00 1449.00
Created Date 25-Jun-2017

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