iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118770

Ensembl Protein ID

ENSTRUP00000015185.1

UniProt Accession

H2SRZ8; H2SRZ8_TAKRU

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006232.1	ENSTRUT00000015254.1	ENSTRUP00000015185.1
ENSTRUG00000006232.1	ENSTRUT00000015255.1	ENSTRUP00000015186.1
ENSTRUG00000006232.1	ENSTRUT00000015256.1	ENSTRUP00000015187.1
ENSTRUG00000006232.1	ENSTRUT00000015257.1	ENSTRUP00000015188.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.90e-10	40.7	761	812

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            +l+dy a +  eL++k G+vv +  + + + +W++g  e  g +Gl+P+ ++  l
   Q: 761  VALFDYVARSPAELSFKVGEVVVL--HSKASSDWWRG--EVGGVKGLIPHKYISVL 812
           68*******************988..59999******..9*************987 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MTSHGKLRKE KGSLAEYESQ MKDLRAQLTD QIKILDSQVE VKQQQLSDLS EFLRRRGDIE 60
AEYARTLDKL TERFTHKTKK KEQWGQSVCQ VWSVLLTQTR LESREHAALG DTCCNTLTQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACATCAC ATGGAAAGCT GAGGAAGGAG AAAGGGAGCC TGGCTGAGTA TGAATCACAG 60
ATGAAAGGTA AGAAGCACCG GATGGGTGCA TGAGCATATC ATGTCCTATG TGAGCACCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR011511--SH3_2
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3

PROSITE

PS51741--F_BAR
PS50238--RHOGAP
PS50002--SH3

Pfam

PF00611--FCH
PF00620--RhoGAP
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA

SMART

SM00055--FCH
SM00324--RhoGAP
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005096--F:GTPase activator activity
GO:0048365--F:Rac GTPase binding
GO:0030336--P:negative regulation of cell migration
GO:0007165--P:signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011131	Astyanax mexicanus	70.00	0.00e+00	1106.00
IUUC-Bta-012780	Bos taurus	46.42	0.00e+00	632.00
IUUC-Hsa-045896	Homo sapiens	53.64	8.00e-30	123.00
IUUC-Mmu-064211	Mus musculus	62.67	4.00e-21	94.40
IUUC-Pma-094731	Petromyzon marinus	30.81	5.00e-21	97.40
IUUC-Ssc-115790	Sus scrofa	45.25	4.00e-178	618.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence