iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092785

Ensembl Protein ID

ENSPANP00000004118.1

UniProt Accession

A0A096MW73; A0A096MW73_PAPAN

Genbank Protein ID

ENSPANP00000004118

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01032075

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000018962.1	ENSPANT00000003191.1	ENSPANP00000004118.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-07	31.7	382	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 382  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 421
           99********.******************....5.555555****8 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MAGNVKKSSG AGGGGGSGGS GSGGLIGLMK DAFQPHHHHH HHHLSPHPPG TVDKKMVEKC 60
WKLMDKVVRL CQNPKLALKN SPPYILDLLP DTYQHLRTIL SRYEGKMETL GENEYFRVFM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCCGGGA GCTGTGGGCA CGCTGGCTGC TCGGAGCCGG TGGCCCGGGG GTCGTCGCTG 60
CGCAGTCTGG CCGCGGCCGG CCGCTTCCCC GAGCTCAACA GTAAGCCGGT CCGCCTCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	91.30	0.00e+00	1474.00
IUUC-Apl-004041	Anas platyrhynchos	84.36	0.00e+00	1372.00
IUUC-Aca-004899	Anolis carolinensis	81.30	0.00e+00	1254.00
IUUC-Ame-010746	Astyanax mexicanus	59.03	4.00e-180	624.00
IUUC-Bta-012759	Bos taurus	91.25	0.00e+00	1519.00
IUUC-Cja-019207	Callithrix jacchus	97.36	0.00e+00	1621.00
IUUC-Cfa-020897	Canis familiaris	92.27	0.00e+00	1524.00
IUUC-Cpo-021453	Cavia porcellus	91.08	0.00e+00	1508.00
IUUC-Csa-023136	Chlorocebus sabaeus	99.89	0.00e+00	1638.00
IUUC-Cho-024282	Choloepus hoffmanni	85.24	0.00e+00	1255.00
IUUC-Cin-025574	Ciona intestinalis	71.54	1.00e-177	615.00
IUUC-Csv-025938	Ciona savignyi	69.87	8.00e-173	599.00
IUUC-Dre-027644	Danio rerio	68.76	0.00e+00	1036.00
IUUC-Dno-030025	Dasypus novemcinctus	92.50	0.00e+00	1477.00
IUUC-Dme-032213	Drosophila melanogaster	74.81	0.00e+00	644.00
IUUC-Ete-033118	Echinops telfairi	79.40	0.00e+00	814.00
IUUC-Eca-033900	Equus caballus	94.01	0.00e+00	1505.00
IUUC-Eeu-035142	Erinaceus europaeus	86.06	0.00e+00	957.00
IUUC-Fca-035455	Felis catus	91.51	0.00e+00	1505.00
IUUC-Fal-037182	Ficedula albicollis	96.75	0.00e+00	902.00
IUUC-Gmo-038698	Gadus morhua	87.30	0.00e+00	870.00
IUUC-Gga-040438	Gallus gallus	83.83	0.00e+00	1392.00
IUUC-Gac-042166	Gasterosteus aculeatus	76.28	0.00e+00	885.00
IUUC-Ggo-045618	Gorilla gorilla	98.24	0.00e+00	1634.00
IUUC-Hsa-046177	Homo sapiens	98.35	0.00e+00	1626.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	96.29	0.00e+00	1010.00
IUUC-Lch-050095	Latimeria chalumnae	73.73	0.00e+00	1168.00
IUUC-Loc-052570	Lepisosteus oculatus	71.83	0.00e+00	1125.00
IUUC-Laf-054008	Loxodonta africana	90.27	0.00e+00	1524.00
IUUC-Mcc-054676	Macaca mulatta	99.78	0.00e+00	1635.00
IUUC-Mga-059239	Meleagris gallopavo	82.85	0.00e+00	1401.00
IUUC-Mmr-060907	Microcebus murinus	92.11	0.00e+00	1521.00
IUUC-Mdo-062595	Monodelphis domestica	88.07	0.00e+00	1409.00
IUUC-Mmu-063725	Mus musculus	90.84	0.00e+00	1569.00
IUUC-Mpu-066771	Mustela putorius furo	91.38	0.00e+00	1528.00
IUUC-Mlu-067206	Myotis lucifugus	76.67	0.00e+00	1091.00
IUUC-Nle-069285	Nomascus leucogenys	95.27	0.00e+00	1523.00
IUUC-Opr-071026	Ochotona princeps	92.65	0.00e+00	1490.00
IUUC-Ont-071954	Oreochromis niloticus	70.45	0.00e+00	1037.00
IUUC-Ocu-074657	Oryctolagus cuniculus	91.76	0.00e+00	1456.00
IUUC-Ola-087165	Oryzias latipes	67.08	0.00e+00	1056.00
IUUC-Oga-088198	Otolemur garnettii	83.12	0.00e+00	1334.00
IUUC-Oar-090258	Ovis aries	91.32	0.00e+00	1456.00
IUUC-Ptr-090710	Pan troglodytes	98.35	0.00e+00	1626.00
IUUC-Pfo-096990	Poecilia formosa	90.16	0.00e+00	819.00
IUUC-Pab-098526	Pongo abelii	98.13	0.00e+00	1623.00
IUUC-Pca-100984	Procavia capensis	78.30	8.00e-169	587.00
IUUC-Pva-102352	Pteropus vampyrus	98.54	0.00e+00	901.00
IUUC-Rno-105876	Rattus norvegicus	90.40	0.00e+00	1550.00
IUUC-Sha-107588	Sarcophilus harrisii	85.97	0.00e+00	1219.00
IUUC-Sar-112959	Sorex araneus	88.36	0.00e+00	1420.00
IUUC-Ssc-115261	Sus scrofa	92.48	0.00e+00	1536.00
IUUC-Tgu-116580	Taeniopygia guttata	81.58	0.00e+00	1311.00
IUUC-Tru-118731	Takifugu rubripes	68.45	0.00e+00	1039.00
IUUC-Tsy-118982	Tarsius syrichta	87.41	0.00e+00	1061.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.71	0.00e+00	1029.00
IUUC-Tbe-128018	Tupaia belangeri	95.60	0.00e+00	1164.00
IUUC-Ttr-128927	Tursiops truncatus	93.45	0.00e+00	1576.00
IUUC-Vpa-130369	Vicugna pacos	93.00	0.00e+00	1446.00
IUUC-Xtr-132474	Xenopus tropicalis	74.00	0.00e+00	1142.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence