iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-34	116.0	184	221
UBD/Beta-Prp	2.00e-54	185.2	329	543

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH + v+c+af  + +++ +GsdD+ +k+W+++ g+ll
   Q: 184  GHLSAVYCVAFdRTgHRIFTGSDDCLVKIWSTHNGRLL 221
           8**********955599***************999987 PP

UBD/Beta-Prp

   S: 57   avkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee............ 131
           + +fs  g +l+tgs+D++i+ +   +++++ +  l+ h+d+v s++f+ +gd+++sGs+d t+r+w  e+ ++ +             
   Q: 329  CSSFSVGGMFLATGSTDHVIRMYflGFEAPEKIAELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWKSIlldmaarisgdt 417
           667888999**************99999**********************************************999***********8 PP
   S: 132  ...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgec 214
               ++  +  v+++++++d++ +v++ +D ++++W++ tg+ll+ l g h d v  l+   fds  + ++s+++dg++ +wd+ +g  
   Q: 418  saeEERFMKPKVTMIAWNQDDSTVVTAVNDHVLKVWSSYTGQLLHNLLG-HADEVFVLEthpFDS--RIMLSAGHDGSIFIWDITKGIK 503
           887777777789************************************9.*********555555..99****************8877 PP
   S: 215  vrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           ++ + +         v + +fs+++++++++ s+g + i+
   Q: 504  MKHYFNMIegqghGAVFDCKFSQDGQHFACTDSHGHLLIF 543
           5555443333334667778999999999999999998886 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAEPSPARRP VPLIESELYF LIARYLSAGP CRRAAQVLVQ ELEQYQLLPK RLDWEGNEHN 60
RSYEELVLSN KHVAPDHLLQ ICQRIGPMLD KEAPPSISRV TSLLGAGRQS LLRTAKDCRH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGTCGCTCG CTCGCTCCCG CCCGGCGCCC CGCCATGGCG GAGCCTTCGC CAGCCCGACG 60
TCCGGTGCCT CTCATCGAGT CGGGTAAGAC GCGGCCGCGC GTCCCCTGCC CGGTGTCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001113	Aegilops tauschii	31.03	4.00e-62	234.00
IUUC-Aml-002332	Ailuropoda melanoleuca	81.56	0.00e+00	2747.00
IUUC-Apl-004083	Anas platyrhynchos	57.85	0.00e+00	1999.00
IUUC-Aca-004348	Anolis carolinensis	70.18	0.00e+00	1880.00
IUUC-Aly-006517	Arabidopsis lyrata	30.88	2.00e-72	268.00
IUUC-Ath-006577	Arabidopsis thaliana	30.73	2.00e-71	265.00
IUUC-Bta-013217	Bos taurus	77.03	0.00e+00	3156.00
IUUC-Bdi-014797	Brachypodium distachyon	29.62	2.00e-58	222.00
IUUC-Bol-015737	Brassica oleracea	29.91	5.00e-74	273.00
IUUC-Bra-017961	Brassica rapa	29.87	3.00e-73	271.00
IUUC-Cja-019966	Callithrix jacchus	77.65	0.00e+00	3207.00
IUUC-Cfa-021037	Canis familiaris	77.50	0.00e+00	3111.00
IUUC-Cpo-021934	Cavia porcellus	88.72	0.00e+00	2679.00
IUUC-Cre-023003	Chlamydomonas reinhardtii	35.56	5.00e-34	139.00
IUUC-Csa-023352	Chlorocebus sabaeus	76.92	0.00e+00	2980.00
IUUC-Cho-024690	Choloepus hoffmanni	59.80	0.00e+00	947.00
IUUC-Dno-028938	Dasypus novemcinctus	74.57	0.00e+00	3070.00
IUUC-Dme-031752	Drosophila melanogaster	49.43	0.00e+00	668.00
IUUC-Eca-034349	Equus caballus	77.74	0.00e+00	3038.00
IUUC-Fca-035485	Felis catus	80.96	0.00e+00	2791.00
IUUC-Fal-037307	Ficedula albicollis	67.95	0.00e+00	2311.00
IUUC-Gga-040865	Gallus gallus	74.78	0.00e+00	2254.00
IUUC-Gma-044324	Glycine max	29.68	4.00e-69	257.00
IUUC-Ggo-045500	Gorilla gorilla	77.81	0.00e+00	3212.00
IUUC-Hsa-046350	Homo sapiens	78.41	0.00e+00	3237.00
IUUC-Hvu-047706	Hordeum vulgare	29.61	1.00e-32	133.00
IUUC-Itr-047962	Ictidomys tridecemlineatus	88.39	0.00e+00	1093.00
IUUC-Lch-049662	Latimeria chalumnae	65.23	0.00e+00	2046.00
IUUC-Lpe-051619	Leersia perrieri	31.38	6.00e-69	256.00
IUUC-Loc-052853	Lepisosteus oculatus	66.31	0.00e+00	1828.00
IUUC-Laf-053848	Loxodonta africana	76.54	0.00e+00	3100.00
IUUC-Mcc-054638	Macaca mulatta	78.07	0.00e+00	3231.00
IUUC-Meu-056739	Macropus eugenii	78.49	0.00e+00	1095.00
IUUC-Mtr-058094	Medicago truncatula	30.09	2.00e-71	265.00
IUUC-Mga-060165	Meleagris gallopavo	75.37	0.00e+00	2246.00
IUUC-Mmr-061227	Microcebus murinus	79.10	0.00e+00	3279.00
IUUC-Mdo-062074	Monodelphis domestica	67.58	0.00e+00	2636.00
IUUC-Mmu-064075	Mus musculus	93.97	0.00e+00	3465.00
IUUC-Mac-065343	Musa acuminata	30.39	3.00e-75	277.00
IUUC-Mpu-066643	Mustela putorius furo	81.26	0.00e+00	2681.00
IUUC-Mlu-067735	Myotis lucifugus	76.08	0.00e+00	3036.00
IUUC-Nle-069402	Nomascus leucogenys	85.03	0.00e+00	2756.00
IUUC-Ont-072298	Oreochromis niloticus	61.79	0.00e+00	1829.00
IUUC-Oan-072954	Ornithorhynchus anatinus	65.95	0.00e+00	2664.00
IUUC-Ocu-074456	Oryctolagus cuniculus	77.76	0.00e+00	3257.00
IUUC-Oba-075709	Oryza barthii	29.11	4.00e-60	227.00
IUUC-Obr-076619	Oryza brachyantha	31.20	2.00e-69	258.00
IUUC-Oin-079669	Oryza indica	31.26	2.00e-47	184.00
IUUC-Olo-080755	Oryza longistaminata	31.49	4.00e-49	191.00
IUUC-Opu-083233	Oryza punctata	30.48	3.00e-64	241.00
IUUC-Oru-085195	Oryza rufipogon	29.11	5.00e-60	227.00
IUUC-Olu-087745	Ostreococcus lucimarinus	28.63	4.00e-57	216.00
IUUC-Oga-087938	Otolemur garnettii	72.83	0.00e+00	2843.00
IUUC-Oar-090214	Ovis aries	76.09	0.00e+00	3023.00
IUUC-Ptr-091213	Pan troglodytes	78.03	0.00e+00	3234.00
IUUC-Pan-092444	Papio anubis	77.95	0.00e+00	3209.00
IUUC-Psi-093271	Pelodiscus sinensis	63.21	0.00e+00	2079.00
IUUC-Ppa-095793	Physcomitrella patens	29.55	5.00e-73	270.00
IUUC-Pfo-097318	Poecilia formosa	62.62	0.00e+00	1776.00
IUUC-Pab-097573	Pongo abelii	76.95	0.00e+00	3127.00
IUUC-Pop-099672	Populus trichocarpa	31.47	2.00e-71	265.00
IUUC-Ppe-101849	Prunus persica	30.01	2.00e-75	278.00
IUUC-Pva-102782	Pteropus vampyrus	77.31	0.00e+00	3133.00
IUUC-Sly-111348	Solanum lycopersicum	30.56	3.00e-75	277.00
IUUC-Sar-113519	Sorex araneus	77.42	0.00e+00	1711.00
IUUC-Sbi-114195	Sorghum bicolor	30.25	2.00e-57	217.00
IUUC-Tgu-116513	Taeniopygia guttata	75.13	0.00e+00	2239.00
IUUC-Tsy-118921	Tarsius syrichta	85.42	0.00e+00	1954.00
IUUC-Tni-120656	Tetraodon nigroviridis	57.61	0.00e+00	1630.00
IUUC-Tca-121615	Theobroma cacao	30.19	4.00e-67	250.00
IUUC-Tae-125478	Triticum aestivum	30.45	2.00e-71	265.00
IUUC-Tur-126809	Triticum urartu	30.28	1.00e-68	255.00
IUUC-Tbe-127663	Tupaia belangeri	81.08	0.00e+00	1156.00
IUUC-Ttr-128561	Tursiops truncatus	75.72	0.00e+00	3001.00
IUUC-Vpa-130444	Vicugna pacos	74.41	0.00e+00	2849.00
IUUC-Vvi-131362	Vitis vinifera	30.63	3.00e-72	267.00
IUUC-Xtr-132278	Xenopus tropicalis	50.93	0.00e+00	1598.00
IUUC-Xma-133633	Xiphophorus maculatus	63.88	0.00e+00	1113.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence