iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054140

Ensembl Protein ID

ENSLAFP00000000673.3

UniProt Accession

G3SME1; G3SME1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000000801.3	ENSLAFT00000000806.3	ENSLAFP00000000673.3
ENSLAFG00000000801.3	ENSLAFT00000032984.1	ENSLAFP00000023294.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.40e-35	117.5	118	155
UBD/Beta-Prp	3.60e-52	177.7	217	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 118  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 155
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl......lrslsgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l       +  +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 217  SGSKRYLSSTGADGTICFWLWDAGTLkinprpTKFTERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 305
           67899***********999999999988888544447777777755522778888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 306  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmttrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 394
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 395  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 478
           ******9.*********999999..89******************999998875544445566667777999999999999988887 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCKHVVWKGS 60
ALAALHCGRP PESPINYGSP PSIVDTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGTATT ACAGACATTT AGCACCTGAT CACTTGCTGC AAATATGTCA TCGACTTGGA 60
CCTCTTCTTG AACAAGAAAT TCCTCAAAGT GTTCCTGGAG TACAGACTTT ATTAGGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR002469--Peptidase_S9B_N
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	96.14	0.00e+00	3155.00
IUUC-Apl-003700	Anas platyrhynchos	85.93	0.00e+00	2869.00
IUUC-Aca-004474	Anolis carolinensis	82.12	0.00e+00	2726.00
IUUC-Bta-013125	Bos taurus	95.57	0.00e+00	3116.00
IUUC-Cja-018868	Callithrix jacchus	93.81	0.00e+00	3181.00
IUUC-Cfa-021179	Canis familiaris	96.42	0.00e+00	3092.00
IUUC-Cpo-022077	Cavia porcellus	90.72	0.00e+00	3055.00
IUUC-Csa-023618	Chlorocebus sabaeus	95.85	0.00e+00	3204.00
IUUC-Cho-024794	Choloepus hoffmanni	90.54	0.00e+00	872.00
IUUC-Dno-030048	Dasypus novemcinctus	96.54	0.00e+00	3151.00
IUUC-Dor-030195	Dipodomys ordii	89.70	0.00e+00	1456.00
IUUC-Ete-032748	Echinops telfairi	85.45	0.00e+00	1186.00
IUUC-Eca-034274	Equus caballus	97.10	0.00e+00	3186.00
IUUC-Eeu-034688	Erinaceus europaeus	85.22	0.00e+00	1415.00
IUUC-Fca-035451	Felis catus	95.74	0.00e+00	3065.00
IUUC-Fal-037465	Ficedula albicollis	85.92	0.00e+00	2825.00
IUUC-Gmo-039451	Gadus morhua	68.38	0.00e+00	721.00
IUUC-Gga-040798	Gallus gallus	85.69	0.00e+00	2855.00
IUUC-Ggo-045347	Gorilla gorilla	98.13	0.00e+00	1603.00
IUUC-Hsa-046757	Homo sapiens	95.97	0.00e+00	3175.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	2.00e-37	149.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	91.93	0.00e+00	1160.00
IUUC-Lch-050646	Latimeria chalumnae	78.70	0.00e+00	2655.00
IUUC-Mcc-055061	Macaca mulatta	96.02	0.00e+00	3209.00
IUUC-Mmr-060837	Microcebus murinus	95.63	0.00e+00	3167.00
IUUC-Mdo-061903	Monodelphis domestica	91.05	0.00e+00	3054.00
IUUC-Mmu-063772	Mus musculus	94.60	0.00e+00	3155.00
IUUC-Mpu-066359	Mustela putorius furo	96.37	0.00e+00	2950.00
IUUC-Mlu-067928	Myotis lucifugus	94.66	0.00e+00	3159.00
IUUC-Nle-070094	Nomascus leucogenys	96.14	0.00e+00	3180.00
IUUC-Opr-070971	Ochotona princeps	73.44	0.00e+00	942.00
IUUC-Ont-072221	Oreochromis niloticus	76.41	0.00e+00	1236.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.39	0.00e+00	2856.00
IUUC-Ocu-074033	Oryctolagus cuniculus	93.81	0.00e+00	2845.00
IUUC-Ogl-077493	Oryza glaberrima	26.93	6.00e-29	124.00
IUUC-Ogu-078641	Oryza glumaepatula	24.28	1.00e-29	126.00
IUUC-Oin-079669	Oryza indica	31.22	1.00e-52	201.00
IUUC-Olo-080755	Oryza longistaminata	31.86	9.00e-55	209.00
IUUC-Oni-082991	Oryza nivara	27.78	2.00e-39	159.00
IUUC-Oga-088578	Otolemur garnettii	95.68	0.00e+00	3142.00
IUUC-Oar-090247	Ovis aries	95.74	0.00e+00	3115.00
IUUC-Ptr-091266	Pan troglodytes	95.85	0.00e+00	3159.00
IUUC-Pan-092734	Papio anubis	96.08	0.00e+00	3206.00
IUUC-Pfo-096191	Poecilia formosa	73.25	0.00e+00	1997.00
IUUC-Pab-098402	Pongo abelii	96.02	0.00e+00	3177.00
IUUC-Pop-099185	Populus trichocarpa	35.42	1.00e-70	262.00
IUUC-Pca-101128	Procavia capensis	88.54	0.00e+00	2934.00
IUUC-Pva-103058	Pteropus vampyrus	95.58	0.00e+00	1586.00
IUUC-Rno-106013	Rattus norvegicus	93.30	0.00e+00	3138.00
IUUC-Sha-107496	Sarcophilus harrisii	91.11	0.00e+00	3053.00
IUUC-Sar-113520	Sorex araneus	91.16	0.00e+00	1536.00
IUUC-Ssc-115461	Sus scrofa	92.67	0.00e+00	3031.00
IUUC-Tgu-116821	Taeniopygia guttata	85.71	0.00e+00	2819.00
IUUC-Tsy-119132	Tarsius syrichta	84.13	0.00e+00	2573.00
IUUC-Tbe-127479	Tupaia belangeri	91.57	0.00e+00	1437.00
IUUC-Ttr-128427	Tursiops truncatus	92.11	0.00e+00	2996.00
IUUC-Vpa-130160	Vicugna pacos	93.30	0.00e+00	3039.00
IUUC-Xtr-132717	Xenopus tropicalis	73.87	0.00e+00	2457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence