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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063913
Ensembl Protein ID ENSMUSP00000102106.1
UniProt Accession Q60631; Q61240; GRB2_MOUSE
Genbank Protein ID AAB40022.1; BAA12862.1; AAH52377.1; AAH85254.1
Protein Name Growth factor receptor-bound protein 2; Adapter protein GRB2; SH2/SH3 adapter GRB2
Genbank Nucleotide ID U07617; D85748; BC052377; BC085254
Gene Name Grb2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000059923.13 ENSMUST00000106497.7 ENSMUSP00000102106.1
ENSMUSG00000059923.13 ENSMUST00000106499.7 ENSMUSP00000102108.1
ENSMUSG00000059923.13 ENSMUST00000106495.7 ENSMUSP00000102104.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.60e-36 125.1 157 214
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  +vq+l+d+++q+d+eL +++Gd+++v+  ++ d +W+kg    +g+ G+fP n+v+ ++
   Q: 157  QPTYVQALFDFDPQEDGELGFRRGDFIHVM--DNSDPNWWKG--ACHGQTGMFPRNYVTPVN 214
           5689*************************9..9*********..8**************997 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced. transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity).
 Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced. transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity).
Protein Sequence
(Fasta)
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW 60
FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063913|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGACCCTG GCGAGGAGCG GAAGCTAGGT TGCTCTGTTG CTTCTGCGAT CGGGCGGCGG 60
CGGCGGCGAG AGCGAGCGGG GCTGCGGCCG GGACGGCGGT CGGGGCAGCG GGCGCCGCAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063913|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
Interpro

IPR000980--SH2
IPR001452--SH3_domain
PROSITE

PS50001--SH2
PS50002--SH3
Pfam

PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0070436--C:Grb2-EGFR complex
GO:0016020--C:membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0012506--C:vesicle membrane
GO:0046875--F:ephrin receptor binding
GO:0005154--F:epidermal growth factor receptor binding
GO:0042802--F:identical protein binding
GO:0043560--F:insulin receptor substrate binding
GO:0005168--F:neurotrophin TRKA receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0019904--F:protein domain specific binding
GO:0019901--F:protein kinase binding
GO:0019903--F:protein phosphatase binding
GO:0003723--F:RNA binding
GO:0017124--F:SH3 domain binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007568--P:aging
GO:0048646--P:anatomical structure formation involved in morphogenesis
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0071479--P:cellular response to ionizing radiation
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0045087--P:innate immune response
GO:0008286--P:insulin receptor signaling pathway
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051291--P:protein heterooligomerization
GO:0007265--P:Ras protein signal transduction
GO:0031623--P:receptor internalization
GO:0042127--P:regulation of cell proliferation
GO:0043408--P:regulation of MAPK cascade
GO:0042770--P:signal transduction in response to DNA damage
KEGG mmu:14784
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001345 Ailuropoda melanoleuca 98.96 5.00e-114 402.00
IUUC-Apl-003322 Anas platyrhynchos 96.86 1.00e-111 394.00
IUUC-Aca-005193 Anolis carolinensis 96.77 7.00e-127 446.00
IUUC-Ago-007965 Ashbya gossypii 48.15 1.00e-12 66.60
IUUC-Ame-010929 Astyanax mexicanus 90.78 3.00e-120 423.00
IUUC-Bta-012932 Bos taurus 99.54 3.00e-129 453.00
IUUC-Cel-018665 Caenorhabditis elegans 58.53 5.00e-72 263.00
IUUC-Cja-019225 Callithrix jacchus 99.54 3.00e-129 453.00
IUUC-Cfa-020887 Canis familiaris 99.54 3.00e-129 453.00
IUUC-Cpo-022488 Cavia porcellus 99.54 3.00e-129 453.00
IUUC-Csa-023326 Chlorocebus sabaeus 99.54 3.00e-129 453.00
IUUC-Cho-024953 Choloepus hoffmanni 81.57 1.00e-97 348.00
IUUC-Cin-025144 Ciona intestinalis 63.38 3.00e-74 271.00
IUUC-Csv-026210 Ciona savignyi 60.66 2.00e-71 261.00
IUUC-Dre-028403 Danio rerio 94.47 4.00e-124 436.00
IUUC-Dno-029187 Dasypus novemcinctus 98.16 4.00e-128 449.00
IUUC-Dor-030763 Dipodomys ordii 99.54 3.00e-129 453.00
IUUC-Dme-031741 Drosophila melanogaster 65.57 3.00e-78 284.00
IUUC-Ete-032354 Echinops telfairi 69.91 2.00e-82 298.00
IUUC-Eca-033222 Equus caballus 99.54 3.00e-129 453.00
IUUC-Eeu-034513 Erinaceus europaeus 73.73 3.00e-88 317.00
IUUC-Fca-036294 Felis catus 99.54 3.00e-129 453.00
IUUC-Fal-037130 Ficedula albicollis 96.31 2.00e-125 440.00
IUUC-Gmo-039546 Gadus morhua 93.09 1.00e-122 431.00
IUUC-Gga-041139 Gallus gallus 97.24 6.00e-127 446.00
IUUC-Gac-041968 Gasterosteus aculeatus 94.01 2.00e-123 434.00
IUUC-Ggo-044562 Gorilla gorilla 99.54 3.00e-129 453.00
IUUC-Hsa-046730 Homo sapiens 99.54 3.00e-129 453.00
IUUC-Itr-049025 Ictidomys tridecemlineatus 99.54 3.00e-129 453.00
IUUC-Lch-050230 Latimeria chalumnae 94.78 4.00e-73 268.00
IUUC-Loc-052723 Lepisosteus oculatus 95.39 4.00e-125 439.00
IUUC-Laf-053774 Loxodonta africana 98.16 4.00e-128 449.00
IUUC-Mcc-054603 Macaca mulatta 99.54 3.00e-129 453.00
IUUC-Meu-056173 Macropus eugenii 80.18 1.00e-99 355.00
IUUC-Mga-059950 Meleagris gallopavo 97.24 6.00e-127 446.00
IUUC-Mmr-060878 Microcebus murinus 99.54 3.00e-129 453.00
IUUC-Mdo-062454 Monodelphis domestica 97.24 6.00e-127 446.00
IUUC-Mpu-066125 Mustela putorius furo 99.54 3.00e-129 453.00
IUUC-Mlu-068007 Myotis lucifugus 99.54 3.00e-129 453.00
IUUC-Nle-069101 Nomascus leucogenys 99.54 3.00e-129 453.00
IUUC-Opr-071075 Ochotona princeps 99.54 3.00e-129 453.00
IUUC-Ont-072253 Oreochromis niloticus 90.78 8.00e-120 422.00
IUUC-Ocu-074583 Oryctolagus cuniculus 99.54 3.00e-129 453.00
IUUC-Ola-086586 Oryzias latipes 94.87 8.00e-86 310.00
IUUC-Oga-089047 Otolemur garnettii 99.54 3.00e-129 453.00
IUUC-Oar-089904 Ovis aries 92.20 5.00e-118 416.00
IUUC-Ptr-090678 Pan troglodytes 99.54 3.00e-129 453.00
IUUC-Pan-092090 Papio anubis 99.54 3.00e-129 453.00
IUUC-Psi-093765 Pelodiscus sinensis 96.77 2.00e-126 444.00
IUUC-Pma-094650 Petromyzon marinus 85.25 9.00e-112 395.00
IUUC-Pfo-096131 Poecilia formosa 94.01 2.00e-123 434.00
IUUC-Pab-098709 Pongo abelii 99.54 3.00e-129 453.00
IUUC-Pca-100581 Procavia capensis 98.43 4.00e-113 399.00
IUUC-Pva-103066 Pteropus vampyrus 99.54 3.00e-129 453.00
IUUC-Rno-105224 Rattus norvegicus 99.54 3.00e-129 453.00
IUUC-Sce-106302 Saccharomyces cerevisiae 51.85 1.00e-15 76.30
IUUC-Sha-107247 Sarcophilus harrisii 97.38 6.00e-112 395.00
IUUC-Sar-113277 Sorex araneus 83.87 2.00e-103 367.00
IUUC-Ssc-115478 Sus scrofa 99.54 3.00e-129 453.00
IUUC-Tgu-117479 Taeniopygia guttata 95.85 5.00e-125 439.00
IUUC-Tru-118451 Takifugu rubripes 84.72 3.00e-107 380.00
IUUC-Tsy-119029 Tarsius syrichta 93.12 4.00e-83 300.00
IUUC-Tbe-128097 Tupaia belangeri 99.08 2.00e-128 450.00
IUUC-Ttr-128871 Tursiops truncatus 99.36 9.00e-90 321.00
IUUC-Vpa-130754 Vicugna pacos 99.54 3.00e-129 453.00
IUUC-Xtr-132275 Xenopus tropicalis 91.27 8.00e-123 432.00
Created Date 25-Jun-2017

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