iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134468

Ensembl Protein ID

CAG82359

UniProt Accession

Q6CBC3; ATG7_YARLI

Genbank Protein ID

CAG82359.1

Protein Name

Ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7

Genbank Nucleotide ID

CR382129

Gene Name

ATG7; YALI0C20119g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_C20119g	CAG82359	CAG82359

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	39.81	1.00e-123	438.00	IUUC-Sce-106413

Active Site

Position(s)	Description	Evidence
486	Glycyl thioester intermediate	{ECO:0000250}

Organism

Yarrowia lipolytica

Functional Description
(View)

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).

Protein Sequence
(Fasta)

MSFTPFSSFL EASFFQTLAA KKLNEYKLDD SPKRVSAEYT WQQGRLVFDS DSFSDRDSHC 60
KGVVECPGTL LNYNTIEEFK GADKKALLAE WGDKMLSGAI MNGSIFRNPE ILNSFLLITF 120

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Nucleotide Sequence
(Fasta)

ATGAGTTTCA CGCCGTTTTC GTCGTTTTTG GAAGCGTCTT TCTTCCAGAC TCTGGCTGCC 60
AAAAAACTCA ATGAGTACAA ACTCGACGAT TCGCCTAAGA GGGTCTCCGC AGAATACACA 120

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Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR006285--Atg7
IPR032197--Atg7_N
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF16420--ATG7_N
PF00899--ThiF

Gene Ontology

GO:0005829--C:cytosol
GO:0097632--C:extrinsic component of pre-autophagosomal structure membrane
GO:0005634--C:nucleus
GO:0019778--F:Atg12 activating enzyme activity
GO:0019779--F:Atg8 activating enzyme activity
GO:0006501--P:C-terminal protein lipidation
GO:0032258--P:CVT pathway
GO:0044805--P:late nucleophagy
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0034727--P:piecemeal microautophagy of nucleus
GO:0032446--P:protein modification by small protein conjugation

KEGG

yli:YALI0C20119g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000588	Aegilops tauschii	30.46	2.00e-64	239.00
IUUC-Aml-002316	Ailuropoda melanoleuca	39.44	8.00e-107	379.00
IUUC-Atr-002579	Amborella trichopoda	36.90	3.00e-114	404.00
IUUC-Apl-003805	Anas platyrhynchos	37.43	3.00e-118	417.00
IUUC-Aca-004618	Anolis carolinensis	37.03	5.00e-96	342.00
IUUC-Aly-005670	Arabidopsis lyrata	35.26	1.00e-95	342.00
IUUC-Ath-007499	Arabidopsis thaliana	35.70	3.00e-99	353.00
IUUC-Ago-007838	Ashbya gossypii	41.45	1.00e-112	398.00
IUUC-Acl-008093	Aspergillus clavatus	50.12	5.00e-113	399.00
IUUC-Afl-008663	Aspergillus flavus	48.85	2.00e-117	414.00
IUUC-Afu-008926	Aspergillus fumigatus	50.00	5.00e-115	406.00
IUUC-Ani-009156	Aspergillus nidulans	41.27	4.00e-129	452.00
IUUC-Ang-009853	Aspergillus niger	47.75	2.00e-52	197.00
IUUC-Aor-010055	Aspergillus oryzae	48.73	5.00e-117	413.00
IUUC-Ate-010281	Aspergillus terreus	45.98	3.00e-102	363.00
IUUC-Ame-010939	Astyanax mexicanus	36.96	3.00e-117	413.00
IUUC-Bgr-012006	Blumeria graminis	38.76	2.00e-120	424.00
IUUC-Bta-012336	Bos taurus	38.14	1.00e-103	368.00
IUUC-Bci-013598	Botrytis cinerea	54.74	2.00e-116	411.00
IUUC-Bdi-014170	Brachypodium distachyon	41.23	3.00e-66	244.00
IUUC-Bol-015357	Brassica oleracea	35.15	1.00e-105	374.00
IUUC-Bra-016835	Brassica rapa	35.59	5.00e-106	376.00
IUUC-Cel-018172	Caenorhabditis elegans	34.75	5.00e-99	353.00
IUUC-Cja-019544	Callithrix jacchus	37.81	4.00e-112	396.00
IUUC-Cfa-021043	Canis familiaris	38.42	7.00e-114	402.00
IUUC-Cpo-022366	Cavia porcellus	37.98	1.00e-112	398.00
IUUC-Cre-022945	Chlamydomonas reinhardtii	50.85	1.00e-73	268.00
IUUC-Csa-023373	Chlorocebus sabaeus	37.81	2.00e-113	400.00
IUUC-Cho-024965	Choloepus hoffmanni	58.27	5.00e-42	164.00
IUUC-Cin-025710	Ciona intestinalis	39.76	2.00e-116	411.00
IUUC-Cgl-026542	Colletotrichum gloeosporioides	42.00	2.00e-139	487.00
IUUC-Cne-027083	Cryptococcus neoformans	40.52	8.00e-115	405.00
IUUC-Dre-028740	Danio rerio	35.27	4.00e-102	363.00
IUUC-Dno-029637	Dasypus novemcinctus	38.47	1.00e-103	368.00
IUUC-Dor-030492	Dipodomys ordii	37.22	2.00e-111	394.00
IUUC-Dse-031267	Dothistroma septosporum	45.83	2.00e-107	381.00
IUUC-Dme-032084	Drosophila melanogaster	35.46	2.00e-112	397.00
IUUC-Ete-032616	Echinops telfairi	35.06	1.00e-95	341.00
IUUC-Eca-033991	Equus caballus	38.30	1.00e-113	402.00
IUUC-Eeu-035126	Erinaceus europaeus	52.36	2.00e-53	201.00
IUUC-Fca-035472	Felis catus	38.74	2.00e-115	407.00
IUUC-Fal-037178	Ficedula albicollis	37.63	9.00e-119	419.00
IUUC-Fox-037901	Fusarium oxysporum	42.10	6.00e-140	489.00
IUUC-Fso-038279	Fusarium solani	40.71	2.00e-134	470.00
IUUC-Gmo-039329	Gadus morhua	39.78	3.00e-122	430.00
IUUC-Ggr-040061	Gaeumannomyces graminis	39.97	2.00e-121	427.00
IUUC-Gga-040244	Gallus gallus	38.02	3.00e-119	420.00
IUUC-Gac-041880	Gasterosteus aculeatus	36.04	1.00e-108	385.00
IUUC-Gma-043235	Glycine max	35.76	9.00e-106	375.00
IUUC-Ggo-045428	Gorilla gorilla	37.96	1.00e-113	402.00
IUUC-Hsa-046183	Homo sapiens	37.81	3.00e-113	400.00
IUUC-Hvu-047509	Hordeum vulgare	41.23	3.00e-67	248.00
IUUC-Itr-048165	Ictidomys tridecemlineatus	38.60	1.00e-107	381.00
IUUC-Kpa-049142	Komagataella pastoris	43.61	2.00e-138	484.00
IUUC-Lch-049601	Latimeria chalumnae	34.78	1.00e-82	298.00
IUUC-Lpe-051496	Leersia perrieri	40.37	2.00e-65	242.00
IUUC-Loc-051751	Lepisosteus oculatus	37.59	6.00e-122	429.00
IUUC-Lma-053203	Leptosphaeria maculans	39.00	8.00e-92	328.00
IUUC-Laf-053424	Loxodonta africana	37.67	2.00e-113	400.00
IUUC-Mcc-054633	Macaca mulatta	37.67	9.00e-113	399.00
IUUC-Meu-056523	Macropus eugenii	36.32	5.00e-96	343.00
IUUC-Mor-056983	Magnaporthe oryzae	40.47	1.00e-124	438.00
IUUC-Mpo-057615	Magnaporthe poae	40.42	9.00e-126	442.00
IUUC-Mtr-058366	Medicago truncatula	36.06	8.00e-100	355.00
IUUC-Mla-058826	Melampsora laricipopulina	37.10	3.00e-121	427.00
IUUC-Mga-059447	Meleagris gallopavo	38.31	2.00e-119	421.00
IUUC-Mvi-060537	Microbotryum violaceum	38.30	3.00e-119	420.00
IUUC-Mmr-060676	Microcebus murinus	38.45	4.00e-114	403.00
IUUC-Mdo-062967	Monodelphis domestica	38.53	6.00e-110	389.00
IUUC-Mmu-063217	Mus musculus	38.33	1.00e-112	398.00
IUUC-Mac-065527	Musa acuminata	38.63	2.00e-104	371.00
IUUC-Mpu-066417	Mustela putorius furo	38.30	4.00e-114	403.00
IUUC-Mlu-067195	Myotis lucifugus	38.20	4.00e-118	416.00
IUUC-Nfi-068576	Neosartorya fischeri	47.05	2.00e-112	397.00
IUUC-Ncr-068867	Neurospora crassa	43.12	9.00e-130	455.00
IUUC-Nle-069447	Nomascus leucogenys	44.54	2.00e-76	276.00
IUUC-Opr-070737	Ochotona princeps	47.56	7.00e-89	319.00
IUUC-Ont-071260	Oreochromis niloticus	36.28	1.00e-112	398.00
IUUC-Oan-073622	Ornithorhynchus anatinus	37.53	2.00e-76	278.00
IUUC-Ocu-074584	Oryctolagus cuniculus	37.57	3.00e-118	417.00
IUUC-Oba-075483	Oryza barthii	41.16	1.00e-65	243.00
IUUC-Obr-076786	Oryza brachyantha	30.82	4.00e-67	248.00
IUUC-Ogl-077388	Oryza glaberrima	41.16	9.00e-66	243.00
IUUC-Ogu-078618	Oryza glumaepatula	40.98	2.00e-65	242.00
IUUC-Oin-080007	Oryza indica	40.85	2.00e-65	242.00
IUUC-Olo-080994	Oryza longistaminata	41.28	6.00e-66	243.00
IUUC-Ome-081735	Oryza meridionalis	41.16	2.00e-65	242.00
IUUC-Oni-082153	Oryza nivara	40.85	2.00e-65	242.00
IUUC-Opu-083146	Oryza punctata	40.85	2.00e-65	242.00
IUUC-Oru-084919	Oryza rufipogon	40.85	2.00e-65	242.00
IUUC-Osa-086182	Oryza sativa	40.85	5.00e-65	241.00
IUUC-Ola-086441	Oryzias latipes	37.39	2.00e-119	421.00
IUUC-Olu-087664	Ostreococcus lucimarinus	36.04	2.00e-106	377.00
IUUC-Oga-089074	Otolemur garnettii	38.91	1.00e-109	388.00
IUUC-Oar-090159	Ovis aries	38.14	4.00e-104	370.00
IUUC-Ptr-091105	Pan troglodytes	38.15	4.00e-98	350.00
IUUC-Pan-092446	Papio anubis	37.81	3.00e-113	400.00
IUUC-Psi-093372	Pelodiscus sinensis	37.96	9.00e-114	402.00
IUUC-Pma-094661	Petromyzon marinus	38.31	5.00e-104	369.00
IUUC-Pno-094813	Phaeosphaeria nodorum	40.31	1.00e-107	381.00
IUUC-Ppa-095224	Physcomitrella patens	35.34	8.00e-105	372.00
IUUC-Pfo-096565	Poecilia formosa	37.35	1.00e-111	395.00
IUUC-Pop-099702	Populus trichocarpa	36.22	2.00e-113	400.00
IUUC-Pca-100324	Procavia capensis	32.64	1.00e-49	189.00
IUUC-Ppe-101416	Prunus persica	34.73	6.00e-104	369.00
IUUC-Pva-102589	Pteropus vampyrus	35.84	2.00e-99	354.00
IUUC-Pgr-103497	Puccinia graminis	35.05	2.00e-118	417.00
IUUC-Ptt-103718	Puccinia triticina	36.88	5.00e-116	409.00
IUUC-Pte-104206	Pyrenophora teres	38.30	9.00e-92	328.00
IUUC-Pyt-104767	Pyrenophora triticirepentis	37.55	5.00e-111	393.00
IUUC-Rno-105911	Rattus norvegicus	38.17	4.00e-112	396.00
IUUC-Sce-106413	Saccharomyces cerevisiae	39.81	1.00e-124	438.00
IUUC-Sha-106679	Sarcophilus harrisii	38.47	1.00e-112	398.00
IUUC-Sja-107928	Schizosaccharomyces japonicus	36.80	8.00e-116	409.00
IUUC-Spo-108107	Schizosaccharomyces pombe	39.02	2.00e-110	390.00
IUUC-Ssl-108570	Sclerotinia sclerotiorum	41.54	3.00e-138	483.00
IUUC-Smo-109677	Selaginella moellendorffii	36.06	2.00e-95	340.00
IUUC-Sit-110319	Setaria italica	41.30	2.00e-67	249.00
IUUC-Sly-111215	Solanum lycopersicum	36.59	3.00e-105	374.00
IUUC-Stu-112442	Solanum tuberosum	36.59	8.00e-103	365.00
IUUC-Sar-113370	Sorex araneus	44.42	3.00e-85	307.00
IUUC-Sbi-114261	Sorghum bicolor	40.92	1.00e-65	243.00
IUUC-Sre-114997	Sporisorium reilianum	36.19	4.00e-118	416.00
IUUC-Ssc-115304	Sus scrofa	39.10	2.00e-115	407.00
IUUC-Tgu-117235	Taeniopygia guttata	37.43	5.00e-117	412.00
IUUC-Tru-118374	Takifugu rubripes	36.73	9.00e-112	395.00
IUUC-Tsy-118966	Tarsius syrichta	34.26	5.00e-84	303.00
IUUC-Tni-120269	Tetraodon nigroviridis	35.85	4.00e-100	357.00
IUUC-Tca-121245	Theobroma cacao	36.43	1.00e-110	392.00
IUUC-Tre-121966	Trichoderma reesei	41.80	5.00e-133	466.00
IUUC-Tvi-122360	Trichoderma virens	42.86	1.00e-127	448.00
IUUC-Tae-125251	Triticum aestivum	30.31	2.00e-64	238.00
IUUC-Tur-126294	Triticum urartu	41.54	7.00e-68	250.00
IUUC-Tme-127117	Tuber melanosporum	42.05	3.00e-139	486.00
IUUC-Tbe-127662	Tupaia belangeri	37.50	5.00e-29	120.00
IUUC-Ttr-129054	Tursiops truncatus	37.43	2.00e-111	394.00
IUUC-Uma-129526	Ustilago maydis	35.12	5.00e-116	409.00
IUUC-Vda-129878	Verticillium dahliae	41.37	1.00e-132	464.00
IUUC-Vpa-130264	Vicugna pacos	35.55	5.00e-63	233.00
IUUC-Vvi-131163	Vitis vinifera	34.55	1.00e-106	378.00
IUUC-Xtr-132328	Xenopus tropicalis	35.73	7.00e-74	269.00
IUUC-Xma-133015	Xiphophorus maculatus	35.52	1.00e-103	368.00
IUUC-Zma-134871	Zea mays	40.12	6.00e-66	243.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence