iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E1	72.82	4.00e-117	419.00	IUUC-Hsa-046777

Active Site

Position(s)	Description	Evidence
260	Glycyl thioester intermediate	{ECO:0000250}

Organism

Caenorhabditis elegans

Functional Description
(View)

E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1.

Protein Sequence
(Fasta)

MSDEQIDKLV SRLDGALNRL GNVKKDHPLE SSSNSKPTHQ PKSPAPYRQK IEKLSAEVVD 60
SNPYSRLMAL QRMGIVNEYE RIREKTVAVV GVGGVGSVVA EMLTRCGIGK LILFDYDKVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTGATTTA AACTTTTAAG CCTCGATATT TAATTTAAAA TATTATTTTT CTATTTTTAT 60
CAAATCTAGA AAATGTAATT AAATTTTCAA TCAAATTTTC TAGTCGTCTT AAGTTGACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR029752--D-isomer_DH_CS1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0071566--F:UFM1 activating enzyme activity
GO:0008340--P:determination of adult lifespan
GO:0000003--P:reproduction
GO:0097501--P:stress response to metal ion

KEGG

cel:CELE_T03F1.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001324	Ailuropoda melanoleuca	73.24	2.00e-117	414.00
IUUC-Atr-002660	Amborella trichopoda	62.34	2.00e-107	380.00
IUUC-Apl-003722	Anas platyrhynchos	72.73	2.00e-117	414.00
IUUC-Aca-004584	Anolis carolinensis	69.58	4.00e-119	420.00
IUUC-Aly-005881	Arabidopsis lyrata	55.53	6.00e-107	379.00
IUUC-Ath-007286	Arabidopsis thaliana	61.05	1.00e-110	391.00
IUUC-Ame-011679	Astyanax mexicanus	66.03	1.00e-98	351.00
IUUC-Bta-012517	Bos taurus	72.13	9.00e-121	425.00
IUUC-Bdi-014894	Brachypodium distachyon	66.79	1.00e-106	378.00
IUUC-Bol-016054	Brassica oleracea	58.33	4.00e-111	393.00
IUUC-Bra-016708	Brassica rapa	60.64	8.00e-112	395.00
IUUC-Cja-019825	Callithrix jacchus	75.32	3.00e-97	346.00
IUUC-Cfa-021160	Canis familiaris	73.24	4.00e-118	416.00
IUUC-Cpo-022255	Cavia porcellus	70.13	3.00e-119	420.00
IUUC-Csa-023827	Chlorocebus sabaeus	63.93	4.00e-120	423.00
IUUC-Cho-025078	Choloepus hoffmanni	73.57	2.00e-117	414.00
IUUC-Cin-025217	Ciona intestinalis	69.23	7.00e-118	415.00
IUUC-Dre-027578	Danio rerio	71.91	4.00e-125	439.00
IUUC-Dno-029330	Dasypus novemcinctus	69.74	1.00e-113	402.00
IUUC-Dor-030425	Dipodomys ordii	71.54	9.00e-53	199.00
IUUC-Dme-031645	Drosophila melanogaster	67.66	5.00e-124	436.00
IUUC-Ete-032912	Echinops telfairi	81.25	5.00e-34	137.00
IUUC-Eca-033247	Equus caballus	63.93	2.00e-119	420.00
IUUC-Eeu-034472	Erinaceus europaeus	70.79	5.00e-110	389.00
IUUC-Fca-035684	Felis catus	72.82	8.00e-119	419.00
IUUC-Fal-037654	Ficedula albicollis	71.02	7.00e-118	416.00
IUUC-Gmo-039449	Gadus morhua	62.06	3.00e-95	340.00
IUUC-Gga-041051	Gallus gallus	68.36	5.00e-122	429.00
IUUC-Gac-042325	Gasterosteus aculeatus	63.39	5.00e-123	432.00
IUUC-Gma-043136	Glycine max	68.88	7.00e-111	392.00
IUUC-Ggo-044414	Gorilla gorilla	72.82	4.00e-119	420.00
IUUC-Hsa-046777	Homo sapiens	72.82	6.00e-119	419.00
IUUC-Hvu-047549	Hordeum vulgare	56.58	4.00e-93	333.00
IUUC-Itr-048175	Ictidomys tridecemlineatus	73.17	6.00e-119	419.00
IUUC-Lch-050142	Latimeria chalumnae	73.14	2.00e-123	434.00
IUUC-Lpe-050769	Leersia perrieri	64.77	8.00e-99	352.00
IUUC-Loc-052405	Lepisosteus oculatus	71.60	1.00e-124	437.00
IUUC-Laf-054152	Loxodonta africana	73.59	5.00e-119	419.00
IUUC-Mcc-055618	Macaca mulatta	72.28	6.00e-109	385.00
IUUC-Meu-056486	Macropus eugenii	71.15	6.00e-117	412.00
IUUC-Mtr-057871	Medicago truncatula	61.79	4.00e-113	400.00
IUUC-Mga-059284	Meleagris gallopavo	67.16	2.00e-121	427.00
IUUC-Mmr-061242	Microcebus murinus	66.85	9.00e-122	428.00
IUUC-Mdo-063034	Monodelphis domestica	64.50	5.00e-120	423.00
IUUC-Mmu-064322	Mus musculus	62.94	1.00e-115	408.00
IUUC-Mac-065128	Musa acuminata	63.11	2.00e-64	242.00
IUUC-Mpu-066438	Mustela putorius furo	72.54	8.00e-117	412.00
IUUC-Mlu-067578	Myotis lucifugus	73.59	4.00e-118	416.00
IUUC-Nle-069542	Nomascus leucogenys	72.47	9.00e-119	418.00
IUUC-Opr-070710	Ochotona princeps	68.83	2.00e-118	417.00
IUUC-Ont-072067	Oreochromis niloticus	69.68	8.00e-125	438.00
IUUC-Oan-073593	Ornithorhynchus anatinus	66.77	2.00e-115	407.00
IUUC-Ocu-073964	Oryctolagus cuniculus	70.76	4.00e-110	390.00
IUUC-Oba-075476	Oryza barthii	61.66	1.00e-109	388.00
IUUC-Obr-076517	Oryza brachyantha	62.35	5.00e-109	386.00
IUUC-Ogu-078664	Oryza glumaepatula	61.96	5.00e-110	389.00
IUUC-Olo-081012	Oryza longistaminata	60.79	6.00e-110	389.00
IUUC-Ome-081129	Oryza meridionalis	61.66	1.00e-109	388.00
IUUC-Oni-082265	Oryza nivara	61.68	4.00e-109	386.00
IUUC-Opu-084121	Oryza punctata	60.48	4.00e-109	386.00
IUUC-Oru-084451	Oryza rufipogon	59.63	4.00e-93	333.00
IUUC-Osa-086132	Oryza sativa	61.66	1.00e-109	388.00
IUUC-Ola-086842	Oryzias latipes	69.42	6.00e-120	422.00
IUUC-Oga-088160	Otolemur garnettii	63.14	4.00e-117	413.00
IUUC-Oar-089362	Ovis aries	71.48	8.00e-120	422.00
IUUC-Ptr-091256	Pan troglodytes	62.60	4.00e-119	419.00
IUUC-Pan-092913	Papio anubis	73.24	3.00e-118	416.00
IUUC-Psi-093740	Pelodiscus sinensis	72.26	5.00e-113	399.00
IUUC-Pma-094485	Petromyzon marinus	73.99	4.00e-92	329.00
IUUC-Ppa-095673	Physcomitrella patens	60.79	6.00e-107	379.00
IUUC-Pfo-096196	Poecilia formosa	68.83	3.00e-120	423.00
IUUC-Pab-098449	Pongo abelii	62.87	2.00e-120	424.00
IUUC-Pop-099049	Populus trichocarpa	57.85	7.00e-108	382.00
IUUC-Pca-100917	Procavia capensis	69.27	1.00e-67	249.00
IUUC-Ppe-101797	Prunus persica	58.45	2.00e-114	404.00
IUUC-Pva-102852	Pteropus vampyrus	70.55	8.00e-117	412.00
IUUC-Rno-105213	Rattus norvegicus	63.32	3.00e-116	410.00
IUUC-Sha-107569	Sarcophilus harrisii	70.82	1.00e-117	414.00
IUUC-Smo-109146	Selaginella moellendorffii	66.67	8.00e-108	382.00
IUUC-Sit-109794	Setaria italica	60.91	7.00e-110	389.00
IUUC-Sly-111622	Solanum lycopersicum	69.44	9.00e-113	399.00
IUUC-Stu-112522	Solanum tuberosum	69.44	5.00e-113	399.00
IUUC-Sar-113045	Sorex araneus	56.87	3.00e-96	343.00
IUUC-Sbi-113861	Sorghum bicolor	60.61	4.00e-109	386.00
IUUC-Ssc-115290	Sus scrofa	70.54	7.00e-96	342.00
IUUC-Tgu-117125	Taeniopygia guttata	71.79	2.00e-120	424.00
IUUC-Tru-118041	Takifugu rubripes	65.57	2.00e-124	437.00
IUUC-Tsy-119300	Tarsius syrichta	65.80	5.00e-93	332.00
IUUC-Tni-120310	Tetraodon nigroviridis	74.39	2.00e-119	420.00
IUUC-Tca-121405	Theobroma cacao	60.83	2.00e-111	394.00
IUUC-Tae-123656	Triticum aestivum	61.66	2.00e-110	390.00
IUUC-Tur-125985	Triticum urartu	61.35	2.00e-110	391.00
IUUC-Tbe-127478	Tupaia belangeri	70.76	2.00e-108	384.00
IUUC-Ttr-128169	Tursiops truncatus	76.19	2.00e-96	344.00
IUUC-Vpa-130508	Vicugna pacos	66.17	3.00e-95	340.00
IUUC-Vvi-131252	Vitis vinifera	63.27	1.00e-111	395.00
IUUC-Xtr-132776	Xenopus tropicalis	72.90	8.00e-122	428.00
IUUC-Xma-133110	Xiphophorus maculatus	70.37	3.00e-123	433.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence