iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.70e-218	725.5	443	930

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv......gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealke 83
           YD  ++++G + ++kl++ +++lvG+g++GcE+lKn++l+Gv      g++tv+D d +e+snlnrqFLfr+++++k+K+ +aaea  +
   Q: 443  YDAFRACIGNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVgtgrekGMVTVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAAEATLK 531
           9**************************************************************************************** PP
   S: 84   lnpdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqk 169
           +np+ +++ah +++++ +e+ +   F++k d+V++aldn+earr+v+++cl++ +pl++sgt+G++G++++i+++lte+y++++dpp++
   Q: 532  INPQLKIDAHLNKVCPATESTYsdeFYNKQDIVITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEE 620
           ********************99******************************************************************* PP
   S: 170  tiPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafa 246
           +iPfctlk++p+a+ehti+wa            +lfnk+++ ++++e+vl+k+++ +++eg+++v  +l s++++ +++++e+a+ +f+
   Q: 621  EIPFCTLKSFPAAVEHTIQWArdkfessfshkpSLFNKFWQAYPSAEDVLQKIQNGQSLEGCFQV-IKLLSRRPRMWSQCVELARLKFE 708
           *****************************************************************.999******************** PP
   S: 247  kttinsikqllksfecdivtkskspfwv.........................................................sfcs 278
           k++++++ qll++f+ d + k++s fw+                                                         +f++
   Q: 709  KYFNHKALQLLHCFPLDTRLKDGSLFWQspkrppspikfdlneplhlsflqnaaklyatvycipfsekdlsvdslmdilsevkiqEFKP 797
           ***************************************************************************************** PP
   S: 279  naealqvpekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlike 360
            ++ +q++e++ k+ +v  +s++     ++l+++  ++ ++k+++++++lsfekddds  ++d++taa+nlra++++iep +d++++k+
   Q: 798  SNKVVQTDETARKPDHVPVSSEDernavFQLEKALSSNKATKSDLQMAVLSFEKDDDSngHIDFITAASNLRAKMYNIEP-ADRFKTKR 885
           ****************998888899**99999999*********************************************.******** PP
   S: 361  iagniipaiattnavvgGlaaqEviKvvsg.kfeplknfflfdae 404
           iag+iipaiat +a+v+Gl+a+E+iKv+ g +f+++kn+fl++a+
   Q: 886  IAGKIIPAIATSTAAVSGLVALEMIKVAGGyPFDAYKNCFLNLAI 930
           *****************************************9886 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MERSEPLAVL SCEEASCSSW GACGASKNLP TMTTESLEID DGLYSRQRYV LGDTAMQKMA 60
KSCVFLSGMG GLGVEIAKNL VLAGIKALTI HDTKKCQAWD LGTNFFLCED DVVNERNRAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCTCGGCC CCGCCCCCTT CCCTGCCTCC CTGACTTGCT GCAGTCTCTC GGAAGGCGAT 60
GGAGCGGTCT GAGCCGTTGG CTGTGCTTTC CTGTGAAGAA GCGTCCTGCT CCTCCTGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR000011--UBQ/SUMO-activ_enz_E1-like

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0019780--F:FAT10 activating enzyme activity
GO:0004839--F:ubiquitin activating enzyme activity
GO:0021764--P:amygdala development
GO:0060996--P:dendritic spine development
GO:0021766--P:hippocampus development
GO:0007612--P:learning
GO:0007626--P:locomotory behavior
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

rno:305268

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001608	Ailuropoda melanoleuca	89.92	0.00e+00	1986.00
IUUC-Apl-004158	Anas platyrhynchos	79.71	0.00e+00	1738.00
IUUC-Aca-005349	Anolis carolinensis	80.41	0.00e+00	1763.00
IUUC-Bta-012696	Bos taurus	88.41	0.00e+00	1956.00
IUUC-Cja-019563	Callithrix jacchus	89.54	0.00e+00	1953.00
IUUC-Cfa-020951	Canis familiaris	90.21	0.00e+00	2001.00
IUUC-Cpo-022307	Cavia porcellus	87.48	0.00e+00	1908.00
IUUC-Csa-023647	Chlorocebus sabaeus	89.73	0.00e+00	1962.00
IUUC-Cho-024682	Choloepus hoffmanni	73.25	0.00e+00	888.00
IUUC-Dre-028022	Danio rerio	67.94	0.00e+00	1492.00
IUUC-Dno-029796	Dasypus novemcinctus	88.29	0.00e+00	1883.00
IUUC-Dor-030981	Dipodomys ordii	75.10	0.00e+00	1501.00
IUUC-Ete-032514	Echinops telfairi	76.37	0.00e+00	1125.00
IUUC-Eca-033697	Equus caballus	89.37	0.00e+00	1936.00
IUUC-Eeu-035323	Erinaceus europaeus	80.10	0.00e+00	1294.00
IUUC-Fca-035858	Felis catus	91.22	0.00e+00	1967.00
IUUC-Fal-036848	Ficedula albicollis	80.08	0.00e+00	1731.00
IUUC-Gmo-039326	Gadus morhua	66.83	0.00e+00	1397.00
IUUC-Gga-040747	Gallus gallus	80.27	0.00e+00	1725.00
IUUC-Gac-041406	Gasterosteus aculeatus	67.51	0.00e+00	1397.00
IUUC-Ggo-044577	Gorilla gorilla	89.27	0.00e+00	1956.00
IUUC-Hsa-046007	Homo sapiens	89.35	0.00e+00	1951.00
IUUC-Itr-048191	Ictidomys tridecemlineatus	93.63	0.00e+00	1058.00
IUUC-Lch-049992	Latimeria chalumnae	71.53	0.00e+00	1515.00
IUUC-Loc-051899	Lepisosteus oculatus	69.50	0.00e+00	1510.00
IUUC-Laf-054413	Loxodonta africana	89.95	0.00e+00	1829.00
IUUC-Mcc-054656	Macaca mulatta	89.73	0.00e+00	1960.00
IUUC-Meu-056463	Macropus eugenii	71.31	0.00e+00	1405.00
IUUC-Mga-059721	Meleagris gallopavo	79.65	0.00e+00	1623.00
IUUC-Mmr-060908	Microcebus murinus	86.31	0.00e+00	1900.00
IUUC-Mdo-062096	Monodelphis domestica	84.11	0.00e+00	1876.00
IUUC-Mmu-064114	Mus musculus	96.77	0.00e+00	2104.00
IUUC-Mpu-066017	Mustela putorius furo	89.73	0.00e+00	1998.00
IUUC-Mlu-068037	Myotis lucifugus	86.48	0.00e+00	1882.00
IUUC-Nle-069494	Nomascus leucogenys	89.07	0.00e+00	1946.00
IUUC-Opr-070910	Ochotona princeps	64.81	5.00e-165	575.00
IUUC-Ont-071592	Oreochromis niloticus	68.66	0.00e+00	1451.00
IUUC-Oan-073268	Ornithorhynchus anatinus	79.29	0.00e+00	1573.00
IUUC-Ocu-074296	Oryctolagus cuniculus	90.21	0.00e+00	1976.00
IUUC-Ola-086376	Oryzias latipes	69.34	0.00e+00	1416.00
IUUC-Oga-088186	Otolemur garnettii	88.31	0.00e+00	1923.00
IUUC-Oar-089307	Ovis aries	89.08	0.00e+00	1967.00
IUUC-Ptr-090609	Pan troglodytes	89.45	0.00e+00	1950.00
IUUC-Pan-092905	Papio anubis	89.20	0.00e+00	1861.00
IUUC-Psi-093489	Pelodiscus sinensis	80.96	0.00e+00	1735.00
IUUC-Pma-094203	Petromyzon marinus	64.86	2.00e-57	214.00
IUUC-Pfo-096670	Poecilia formosa	69.77	0.00e+00	1478.00
IUUC-Pab-098418	Pongo abelii	89.54	0.00e+00	1951.00
IUUC-Pca-100889	Procavia capensis	73.57	0.00e+00	1549.00
IUUC-Pva-103144	Pteropus vampyrus	77.95	0.00e+00	1681.00
IUUC-Sha-107388	Sarcophilus harrisii	85.83	0.00e+00	1854.00
IUUC-Sar-113128	Sorex araneus	87.26	0.00e+00	1887.00
IUUC-Ssc-116117	Sus scrofa	89.17	0.00e+00	1966.00
IUUC-Tgu-116565	Taeniopygia guttata	80.02	0.00e+00	1737.00
IUUC-Tru-118591	Takifugu rubripes	67.54	0.00e+00	1425.00
IUUC-Tsy-119436	Tarsius syrichta	78.14	0.00e+00	1672.00
IUUC-Tni-120880	Tetraodon nigroviridis	67.12	0.00e+00	1417.00
IUUC-Tbe-127714	Tupaia belangeri	78.19	0.00e+00	1384.00
IUUC-Ttr-129159	Tursiops truncatus	78.14	0.00e+00	1659.00
IUUC-Vpa-130716	Vicugna pacos	87.49	0.00e+00	1832.00
IUUC-Xtr-132947	Xenopus tropicalis	68.75	0.00e+00	1504.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence