iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046496

Ensembl Protein ID

ENSP00000451261.1

UniProt Accession

Q9Y385; A8K3F9; Q53F25; Q5W0N4; Q9BZ32; Q9NQL3; Q9NY66; Q9P011; Q9P0S0; Q9UF10; UB2J1_HUMAN

Genbank Protein ID

CAB83212.1; AAF21505.1; AAD34071.1; AAF36125.1; AAF29117.1; BAF83263.1; BAD97184.1; CAH70228.1; CAH70228.1; CAI19635.1; CAI19635.1; EAW48555.1; EAW48556.1; AAH13973.1

Protein Name

Ubiquitin-conjugating enzyme E2 J1; E2 ubiquitin-conjugating enzyme J1; Non-canonical ubiquitin-conjugating enzyme 1; Yeast ubiquitin-conjugating enzyme UBC6 homolog E

Genbank Nucleotide ID

AJ245898; U93243; AF151834; AF151039; AF161502; AK290574; AK223464; AL138717; AL139804; AL139804; AL138717; CH471051; CH471051; BC013973

Gene Name

UBE2J1; NCUBE1; CGI-76; HSPC153; HSPC205

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198833.6	ENST00000435041.2	ENSP00000451261.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20498703; 19625452; 16847254

Classification

Family	E-value	Score	Start	End
E2/UBC	3.10e-25	90.2	14	119

Active Site

Position(s)	Description	Evidence
91	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.eeek 91
           Rl+ke++el kdp+++++a+p ++ +l+ew++++ Gp+d+ ++ggv++ +i +p++YP+kPP++ +lt   ++ ++   k+Clsi + ++e+
   Q: 14   RLMKEAAEL-KDPTDHYHAQPLED-NLFEWHFTVRGPPDSDFDGGVYHGRIVLPPEYPMKPPSIILLTA--NGRFEVGKKICLSISGhHPET 101
           9*******9.99************.9******************************************9..9999999********549*** PP
   S: 92   Wspalsvesvllsiqsll 109
           W+p +s+++ ll+i+ ++
   Q: 102  WQPSWSIRTALLAIIGFM 119
           ***************998 PP

Organism

Homo sapiens

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Protein Sequence
(Fasta)

METRYNLKSP AVKRLMKEAA ELKDPTDHYH AQPLEDNLFE WHFTVRGPPD SDFDGGVYHG 60
RIVLPPEYPM KPPSIILLTA NGRFEVGKKI CLSISGHHPE TWQPSWSIRT ALLAIIGFMP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGGCGCCC GGTTCAGCGC CGCCCCGGCC GGCGCCGGTG CCTGCCAGGC ACTCAGGGAG 60
GCGGGGGCGC AGTGGAGGAG GCGGCGCCAT CGCGAAGCGA GCGCCTCGCC CGCACTCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1904153--P:negative regulation of retrograde protein transport, ER to cytosol
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0042534--P:regulation of tumor necrosis factor biosynthetic process
GO:0007286--P:spermatid development
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

hsa:51465

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001180	Aegilops tauschii	34.26	4.00e-35	142.00
IUUC-Aml-002404	Ailuropoda melanoleuca	95.60	9.00e-156	542.00
IUUC-Atr-002806	Amborella trichopoda	63.70	2.00e-55	209.00
IUUC-Apl-003507	Anas platyrhynchos	77.81	2.00e-124	438.00
IUUC-Aca-004697	Anolis carolinensis	74.92	2.00e-115	408.00
IUUC-Aly-005556	Arabidopsis lyrata	61.81	2.00e-54	206.00
IUUC-Ath-007477	Arabidopsis thaliana	61.11	4.00e-54	204.00
IUUC-Acl-008101	Aspergillus clavatus	56.46	2.00e-46	179.00
IUUC-Afl-008466	Aspergillus flavus	56.13	4.00e-45	175.00
IUUC-Afu-009109	Aspergillus fumigatus	53.46	1.00e-40	160.00
IUUC-Ani-009343	Aspergillus nidulans	53.85	3.00e-42	165.00
IUUC-Ang-009509	Aspergillus niger	57.94	5.00e-41	159.00
IUUC-Aor-010210	Aspergillus oryzae	56.13	4.00e-45	174.00
IUUC-Ate-010571	Aspergillus terreus	49.35	4.00e-39	156.00
IUUC-Ame-010806	Astyanax mexicanus	61.63	2.00e-89	322.00
IUUC-Bgr-012063	Blumeria graminis	45.96	6.00e-50	191.00
IUUC-Bta-012638	Bos taurus	93.99	8.00e-152	529.00
IUUC-Bci-013709	Botrytis cinerea	45.00	3.00e-49	188.00
IUUC-Bdi-014694	Brachypodium distachyon	60.42	8.00e-52	197.00
IUUC-Bol-015399	Brassica oleracea	60.27	7.00e-54	204.00
IUUC-Bra-017645	Brassica rapa	60.27	7.00e-54	204.00
IUUC-Cel-018452	Caenorhabditis elegans	61.70	8.00e-70	257.00
IUUC-Cja-019087	Callithrix jacchus	97.80	1.00e-159	555.00
IUUC-Cfa-020218	Canis familiaris	95.45	3.00e-149	521.00
IUUC-Cpo-022552	Cavia porcellus	94.97	5.00e-161	560.00
IUUC-Cre-022888	Chlamydomonas reinhardtii	60.14	4.00e-54	203.00
IUUC-Csa-024028	Chlorocebus sabaeus	97.80	7.00e-160	556.00
IUUC-Cho-024606	Choloepus hoffmanni	70.13	3.00e-99	354.00
IUUC-Cin-025631	Ciona intestinalis	69.52	1.00e-77	283.00
IUUC-Csv-026321	Ciona savignyi	68.95	9.00e-77	280.00
IUUC-Cgl-026755	Colletotrichum gloeosporioides	47.31	3.00e-49	189.00
IUUC-Cne-026839	Cryptococcus neoformans	45.95	4.00e-41	161.00
IUUC-Cme-027189	Cyanidioschyzon merolae	60.13	3.00e-45	175.00
IUUC-Dre-027569	Danio rerio	83.51	4.00e-92	331.00
IUUC-Dno-029214	Dasypus novemcinctus	94.65	3.00e-155	540.00
IUUC-Dor-030145	Dipodomys ordii	64.85	4.00e-56	211.00
IUUC-Dse-031537	Dothistroma septosporum	56.96	4.00e-52	197.00
IUUC-Ete-033083	Echinops telfairi	91.51	3.00e-143	501.00
IUUC-Eca-034179	Equus caballus	94.16	2.00e-152	531.00
IUUC-Eeu-035115	Erinaceus europaeus	78.62	1.00e-113	402.00
IUUC-Fca-036083	Felis catus	96.23	4.00e-157	546.00
IUUC-Fal-037289	Ficedula albicollis	76.39	4.00e-115	407.00
IUUC-Fox-038027	Fusarium oxysporum	58.04	9.00e-41	160.00
IUUC-Fso-038254	Fusarium solani	52.53	1.00e-50	193.00
IUUC-Ggr-039884	Gaeumannomyces graminis	55.92	4.00e-50	191.00
IUUC-Gga-041156	Gallus gallus	75.24	2.00e-124	438.00
IUUC-Gac-041807	Gasterosteus aculeatus	48.21	6.00e-39	154.00
IUUC-Gma-044356	Glycine max	63.27	1.00e-56	213.00
IUUC-Ggo-044450	Gorilla gorilla	99.69	2.00e-162	564.00
IUUC-Hvu-047328	Hordeum vulgare	59.72	3.00e-51	195.00
IUUC-Itr-048629	Ictidomys tridecemlineatus	96.54	3.00e-159	554.00
IUUC-Lch-050348	Latimeria chalumnae	68.32	4.00e-110	390.00
IUUC-Lpe-050862	Leersia perrieri	60.42	3.00e-52	198.00
IUUC-Loc-052465	Lepisosteus oculatus	79.67	9.00e-86	310.00
IUUC-Lma-053257	Leptosphaeria maculans	51.08	3.00e-53	201.00
IUUC-Laf-053830	Loxodonta africana	94.97	2.00e-160	558.00
IUUC-Mcc-054880	Macaca mulatta	97.80	5.00e-161	560.00
IUUC-Mor-057183	Magnaporthe oryzae	50.91	1.00e-49	190.00
IUUC-Mpo-057391	Magnaporthe poae	55.63	1.00e-50	193.00
IUUC-Mtr-058479	Medicago truncatula	61.90	6.00e-56	211.00
IUUC-Mga-059321	Meleagris gallopavo	74.04	3.00e-119	421.00
IUUC-Mvi-060366	Microbotryum violaceum	59.48	1.00e-50	193.00
IUUC-Mmr-061717	Microcebus murinus	96.74	2.00e-151	528.00
IUUC-Mdo-061865	Monodelphis domestica	84.74	2.00e-126	445.00
IUUC-Mmu-064049	Mus musculus	92.45	5.00e-148	516.00
IUUC-Mac-064669	Musa acuminata	58.90	2.00e-52	199.00
IUUC-Mpu-066177	Mustela putorius furo	95.38	4.00e-146	510.00
IUUC-Mlu-067037	Myotis lucifugus	92.86	6.00e-147	513.00
IUUC-Nfi-068283	Neosartorya fischeri	46.35	4.00e-43	168.00
IUUC-Ncr-068645	Neurospora crassa	46.29	2.00e-49	189.00
IUUC-Nle-069166	Nomascus leucogenys	99.06	6.00e-163	566.00
IUUC-Opr-070562	Ochotona princeps	100.00	7.00e-20	91.30
IUUC-Ont-072096	Oreochromis niloticus	66.67	1.00e-109	389.00
IUUC-Oan-073369	Ornithorhynchus anatinus	78.93	6.00e-114	403.00
IUUC-Ocu-074815	Oryctolagus cuniculus	94.03	4.00e-153	533.00
IUUC-Oba-075649	Oryza barthii	60.42	3.00e-52	199.00
IUUC-Obr-076169	Oryza brachyantha	60.69	6.00e-53	201.00
IUUC-Ogl-077144	Oryza glaberrima	60.42	3.00e-52	199.00
IUUC-Ogu-078255	Oryza glumaepatula	60.42	2.00e-52	199.00
IUUC-Oin-079510	Oryza indica	61.11	3.00e-51	195.00
IUUC-Olo-080589	Oryza longistaminata	46.77	6.00e-46	178.00
IUUC-Ome-081849	Oryza meridionalis	55.41	2.00e-49	189.00
IUUC-Oni-082959	Oryza nivara	60.42	3.00e-52	198.00
IUUC-Opu-083736	Oryza punctata	60.69	4.00e-52	198.00
IUUC-Oru-084215	Oryza rufipogon	60.42	3.00e-52	198.00
IUUC-Osa-085722	Oryza sativa	60.42	3.00e-52	198.00
IUUC-Ola-086717	Oryzias latipes	82.97	8.00e-93	333.00
IUUC-Olu-087750	Ostreococcus lucimarinus	66.06	2.00e-41	160.00
IUUC-Oga-088848	Otolemur garnettii	83.65	2.00e-129	454.00
IUUC-Oar-090134	Ovis aries	95.13	3.00e-149	521.00
IUUC-Ptr-091314	Pan troglodytes	99.69	2.00e-162	564.00
IUUC-Pan-092103	Papio anubis	98.11	2.00e-160	558.00
IUUC-Psi-093668	Pelodiscus sinensis	81.51	1.00e-110	392.00
IUUC-Pno-094982	Phaeosphaeria nodorum	56.38	4.00e-49	187.00
IUUC-Ppa-095836	Physcomitrella patens	62.11	2.00e-59	222.00
IUUC-Pfo-096964	Poecilia formosa	64.20	9.00e-102	363.00
IUUC-Pab-097857	Pongo abelii	98.43	6.00e-160	556.00
IUUC-Pop-099025	Populus trichocarpa	63.01	5.00e-56	211.00
IUUC-Pca-101108	Procavia capensis	92.89	2.00e-104	372.00
IUUC-Ppe-101444	Prunus persica	61.38	1.00e-54	206.00
IUUC-Pva-102297	Pteropus vampyrus	83.07	9.00e-123	432.00
IUUC-Pte-104112	Pyrenophora teres	54.27	3.00e-52	198.00
IUUC-Pyt-104824	Pyrenophora triticirepentis	56.06	4.00e-44	171.00
IUUC-Rno-105336	Rattus norvegicus	97.65	5.00e-124	436.00
IUUC-Sha-107324	Sarcophilus harrisii	85.62	8.00e-131	459.00
IUUC-Smo-109549	Selaginella moellendorffii	68.75	1.00e-60	226.00
IUUC-Sit-110794	Setaria italica	60.00	1.00e-51	196.00
IUUC-Sly-111585	Solanum lycopersicum	64.19	2.00e-57	215.00
IUUC-Stu-111996	Solanum tuberosum	64.19	3.00e-57	214.00
IUUC-Sar-113063	Sorex araneus	92.51	4.00e-143	500.00
IUUC-Sbi-114593	Sorghum bicolor	60.00	9.00e-52	197.00
IUUC-Sre-115043	Sporisorium reilianum	52.51	5.00e-51	194.00
IUUC-Ssc-115523	Sus scrofa	95.28	4.00e-149	520.00
IUUC-Tgu-116966	Taeniopygia guttata	73.35	1.00e-122	432.00
IUUC-Tru-117737	Takifugu rubripes	61.63	1.00e-100	359.00
IUUC-Tsy-119190	Tarsius syrichta	100.00	4.00e-62	231.00
IUUC-Tni-120283	Tetraodon nigroviridis	94.59	6.00e-41	158.00
IUUC-Tca-120992	Theobroma cacao	64.38	2.00e-56	212.00
IUUC-Tre-122028	Trichoderma reesei	48.39	6.00e-50	191.00
IUUC-Tvi-122637	Trichoderma virens	48.17	5.00e-51	194.00
IUUC-Tae-124782	Triticum aestivum	59.72	2.00e-51	196.00
IUUC-Tme-126962	Tuber melanosporum	41.30	2.00e-51	196.00
IUUC-Tbe-127743	Tupaia belangeri	95.44	5.00e-149	520.00
IUUC-Ttr-129193	Tursiops truncatus	92.83	1.00e-144	505.00
IUUC-Uma-129586	Ustilago maydis	47.92	8.00e-50	190.00
IUUC-Vda-129959	Verticillium dahliae	54.43	1.00e-50	193.00
IUUC-Vpa-130404	Vicugna pacos	94.79	3.00e-148	517.00
IUUC-Vvi-130893	Vitis vinifera	62.33	2.00e-55	209.00
IUUC-Xtr-131832	Xenopus tropicalis	70.83	9.00e-104	369.00
IUUC-Zma-135443	Zea mays	60.42	3.00e-52	198.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence