iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054008

UUCD1 version

UUC-LoA-00253

Ensembl Protein ID

ENSLAFP00000006035.3

UniProt Accession

G3SZI9; G3SZI9_LOXAF

Protein Name

Uncharacterized protein

Gene Name

CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000007171.3	ENSLAFT00000028529.1	ENSLAFP00000028906.1
ENSLAFG00000007171.3	ENSLAFT00000007171.3	ENSLAFP00000006035.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.60e-07	31.4	378	417

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pCgH+++++Cl  w    + +s  + CP Cr
   Q: 378  CKICAENDKD-VKIEPCGHLMCTSCLTSW----Q-ESEGQGCPFCR 417
           99********.******************....5.555555****8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAGNVKKSSG AGGGGSGGSG SGGLIGLMKD AFQPHHHHHH LSPHPPGTVD KKMEKCWKLM 60
DKVVRLCQNP KLALKNSPPY ILDLLPDTYQ HLRTILARYE GKMETLGENE YFRVFMENLM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCCGGCA GAGGGCGCAC GCACGGCCCG GACCCAGGCG GAGGCTCCGC TTGGCCCCGC 60
CCCGGCCCGC CCGCAGGGGT CGGCTCGGCC GCGGCTTTCC GGGCGCTGTG GGTACGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR009060--UBA-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3
PF00627--UBA

SMART

SM00184--RING
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0016600--C:flotillin complex
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002357	Ailuropoda melanoleuca	90.44	0.00e+00	1446.00
IUUC-Apl-004041	Anas platyrhynchos	83.98	0.00e+00	1365.00
IUUC-Aca-004899	Anolis carolinensis	79.59	0.00e+00	1258.00
IUUC-Ame-010746	Astyanax mexicanus	59.32	2.00e-177	615.00
IUUC-Bta-012759	Bos taurus	89.75	0.00e+00	1490.00
IUUC-Cel-018674	Caenorhabditis elegans	55.50	2.00e-132	465.00
IUUC-Cja-019207	Callithrix jacchus	89.97	0.00e+00	1519.00
IUUC-Cfa-020897	Canis familiaris	90.00	0.00e+00	1477.00
IUUC-Cpo-021453	Cavia porcellus	89.32	0.00e+00	1484.00
IUUC-Csa-023136	Chlorocebus sabaeus	89.95	0.00e+00	1505.00
IUUC-Cho-024282	Choloepus hoffmanni	83.26	0.00e+00	1225.00
IUUC-Cin-025574	Ciona intestinalis	71.54	8.00e-177	612.00
IUUC-Csv-025938	Ciona savignyi	69.87	6.00e-172	596.00
IUUC-Dre-027644	Danio rerio	68.36	0.00e+00	1018.00
IUUC-Dno-030025	Dasypus novemcinctus	91.32	0.00e+00	1454.00
IUUC-Dme-032213	Drosophila melanogaster	74.55	0.00e+00	639.00
IUUC-Ete-033118	Echinops telfairi	78.98	0.00e+00	811.00
IUUC-Eca-033900	Equus caballus	91.78	0.00e+00	1467.00
IUUC-Eeu-035142	Erinaceus europaeus	85.91	0.00e+00	955.00
IUUC-Fca-035455	Felis catus	89.17	0.00e+00	1472.00
IUUC-Fal-037182	Ficedula albicollis	94.59	0.00e+00	895.00
IUUC-Gmo-038698	Gadus morhua	86.48	0.00e+00	862.00
IUUC-Gga-040438	Gallus gallus	83.82	0.00e+00	1391.00
IUUC-Gac-042166	Gasterosteus aculeatus	76.36	0.00e+00	874.00
IUUC-Ggo-045618	Gorilla gorilla	90.48	0.00e+00	1519.00
IUUC-Hsa-046177	Homo sapiens	90.15	0.00e+00	1510.00
IUUC-Itr-048795	Ictidomys tridecemlineatus	95.36	0.00e+00	997.00
IUUC-Lch-050095	Latimeria chalumnae	74.03	0.00e+00	1168.00
IUUC-Loc-052570	Lepisosteus oculatus	71.53	0.00e+00	1109.00
IUUC-Mcc-054676	Macaca mulatta	89.84	0.00e+00	1502.00
IUUC-Mga-059239	Meleagris gallopavo	83.00	0.00e+00	1391.00
IUUC-Mmr-060907	Microcebus murinus	89.42	0.00e+00	1478.00
IUUC-Mdo-062595	Monodelphis domestica	88.01	0.00e+00	1412.00
IUUC-Mmu-063725	Mus musculus	90.48	0.00e+00	1547.00
IUUC-Mpu-066771	Mustela putorius furo	88.50	0.00e+00	1482.00
IUUC-Mlu-067206	Myotis lucifugus	76.20	0.00e+00	1092.00
IUUC-Nle-069285	Nomascus leucogenys	87.64	0.00e+00	1415.00
IUUC-Opr-071026	Ochotona princeps	89.66	0.00e+00	1452.00
IUUC-Ont-071954	Oreochromis niloticus	68.53	0.00e+00	1036.00
IUUC-Ocu-074657	Oryctolagus cuniculus	91.02	0.00e+00	1432.00
IUUC-Ola-087165	Oryzias latipes	65.90	0.00e+00	1044.00
IUUC-Oga-088198	Otolemur garnettii	79.78	0.00e+00	1296.00
IUUC-Oar-090258	Ovis aries	89.89	0.00e+00	1430.00
IUUC-Ptr-090710	Pan troglodytes	90.15	0.00e+00	1510.00
IUUC-Pan-092785	Papio anubis	89.84	0.00e+00	1503.00
IUUC-Pfo-096990	Poecilia formosa	89.47	0.00e+00	811.00
IUUC-Pab-098526	Pongo abelii	90.91	0.00e+00	1515.00
IUUC-Pca-100984	Procavia capensis	81.76	3.00e-176	612.00
IUUC-Pva-102352	Pteropus vampyrus	94.98	0.00e+00	882.00
IUUC-Rno-105876	Rattus norvegicus	88.74	0.00e+00	1502.00
IUUC-Sha-107588	Sarcophilus harrisii	85.77	0.00e+00	1221.00
IUUC-Sar-112959	Sorex araneus	86.65	0.00e+00	1407.00
IUUC-Ssc-115261	Sus scrofa	90.26	0.00e+00	1498.00
IUUC-Tgu-116580	Taeniopygia guttata	80.62	0.00e+00	1305.00
IUUC-Tru-118731	Takifugu rubripes	67.87	0.00e+00	1032.00
IUUC-Tsy-118982	Tarsius syrichta	82.01	0.00e+00	1002.00
IUUC-Tni-120725	Tetraodon nigroviridis	68.15	0.00e+00	1029.00
IUUC-Tbe-128018	Tupaia belangeri	94.94	0.00e+00	1143.00
IUUC-Ttr-128927	Tursiops truncatus	91.47	0.00e+00	1536.00
IUUC-Vpa-130369	Vicugna pacos	90.82	0.00e+00	1396.00
IUUC-Xtr-132474	Xenopus tropicalis	73.65	0.00e+00	1138.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence