iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118593

UUCD1 version

UUC-TaR-00570

Ensembl Protein ID

ENSTRUP00000029922.1

UniProt Accession

H2TZ13; H2TZ13_TAKRU

Protein Name

Uncharacterized protein

Gene Name

cul2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000011837.1	ENSTRUT00000030038.1	ENSTRUP00000029921.1
ENSTRUG00000011837.1	ENSTRUT00000030039.1	ENSTRUP00000029922.1
ENSTRUG00000011837.1	ENSTRUT00000030040.1	ENSTRUP00000029923.1
ENSTRUG00000011837.1	ENSTRUT00000030041.1	ENSTRUP00000029924.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.70e-182	608.5	18	469

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...vgaklYkklkevleefikqvkkkveesedeqlLktynreWekfreqlkvlrki 86
           l +++k++++ ++v +++++++++++y+lc+++   +g++lY+++k +le++++q+ kkv +se e++L +y+r+W ++++++++++++
   Q: 18   LLTTIKAVVMLDYVeRATWNDRFSDIYALCVAYpepLGERLYTETKVFLENHVRQLYKKVLDSE-EKVLSMYHRYWDEYSKGADYMDCL 105
           6689***********************************************************5.55********************** PP
   S: 87   fayldrtyvkk.................skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLsl 158
           ++yl+++++kk                 ++ ++e+ +Lald+wrk ++e++++ l+++llk i+++R ge+ ++ +++gv++s+v++++
   Q: 106  YRYLNTQFIKKnklteadlqygyggvdmNEPLMEIGELALDTWRKLMIEPLQAVLIRMLLKEIKSDRCGENPNQTVIHGVINSFVHVEQ 194
           ***********999999998888888877778********************************************************9 PP
   S: 159  nk....laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllael 243
           +k    l++y+e FE +fl++t e+yk+e++++lqe+++++Y++kv  rl++ee r+++yl++s++ k++++++++++a+hl++l+ e+
   Q: 195  YKkkcpLKFYQEIFEGLFLTKTGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEMRCRKYLHPSSYAKVIHECQQRMVADHLHFLHGEC 283
           999************************************************************************************** PP
   S: 244  vallrdkkted....lsrmykLlsrvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlka 328
           ++++r++k++     +++my Ll+ v+ngl ++++el+ hi+++g + +++  +e++p+ +Ve++le+++k+ +l+++++n d++F++a
   Q: 284  QNIIRQEKRDGqsfyMANMYTLLRAVSNGLPHMIQELQVHIHNEGIRGTSNLSQENMPTLFVESVLEVHSKFVQLINTVLNGDQHFMSA 372
           *******9995344489************************************************************************ PP
   S: 329  ldkafetfvnknsvlka...............................akspEllAryiDqlLrksskglteeeleaqldkvllvfkyi 386
           ldka++++vn ++ ++                                + ++ +lA+y+D+lL+ks+kg+te+e+e++l+++++vfkyi
   Q: 373  LDKALTSVVNFREPKSIckapelvshkhshkqpppthldthgfdqvmfCLVSAQLAKYCDNLLKKSAKGMTENEVEDKLTSFITVFKYI 461
           **********9988888888********************************************************************* PP
   S: 387  sekdvFek 394
           ++kd+F+k
   Q: 462  DDKDIFQK 469
           ******98 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

TMSLKPRVVD FDETWNKLLT TIKAVVMLDY VERATWNDRF SDIYALCVAY PEPLGERLYT 60
ETKVFLENHV RQLYKKVLDS EEKVLSMYHR YWDEYSKGAD YMDCLYRYLN TQFIKKNKLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACAGTACAA TGTCCTTAAA GCCACGGGTG GTGGATTTTG ATGAGACATG GAACAAGCTA 60
CTCACAACAA TCAAGGCAGT GGTGATGCTT GATTATGTGG AGAGAGCCAC ATGGAACGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0043009--P:chordate embryonic development
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0001944--P:vasculature development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001969	Ailuropoda melanoleuca	81.53	0.00e+00	1395.00
IUUC-Apl-004067	Anas platyrhynchos	82.36	0.00e+00	1408.00
IUUC-Aca-004534	Anolis carolinensis	79.21	0.00e+00	1365.00
IUUC-Ame-011695	Astyanax mexicanus	84.84	0.00e+00	1441.00
IUUC-Bta-013074	Bos taurus	81.62	0.00e+00	1395.00
IUUC-Cel-018431	Caenorhabditis elegans	38.36	3.00e-160	558.00
IUUC-Cja-019371	Callithrix jacchus	81.53	0.00e+00	1395.00
IUUC-Cfa-020508	Canis familiaris	81.38	0.00e+00	1391.00
IUUC-Cpo-021851	Cavia porcellus	80.67	0.00e+00	1379.00
IUUC-Csa-023583	Chlorocebus sabaeus	81.53	0.00e+00	1389.00
IUUC-Cho-024308	Choloepus hoffmanni	81.36	2.00e-174	605.00
IUUC-Cin-025350	Ciona intestinalis	41.62	0.00e+00	664.00
IUUC-Csv-026096	Ciona savignyi	43.33	0.00e+00	650.00
IUUC-Dre-028828	Danio rerio	83.65	0.00e+00	1419.00
IUUC-Dno-029709	Dasypus novemcinctus	81.15	0.00e+00	1387.00
IUUC-Dor-030319	Dipodomys ordii	67.32	0.00e+00	852.00
IUUC-Dme-031938	Drosophila melanogaster	45.42	0.00e+00	704.00
IUUC-Ete-032756	Echinops telfairi	70.17	0.00e+00	756.00
IUUC-Eca-034019	Equus caballus	81.29	0.00e+00	1390.00
IUUC-Eeu-034914	Erinaceus europaeus	77.10	0.00e+00	952.00
IUUC-Fca-035926	Felis catus	81.38	0.00e+00	1391.00
IUUC-Fal-037627	Ficedula albicollis	82.10	0.00e+00	1397.00
IUUC-Gmo-038728	Gadus morhua	84.88	0.00e+00	1436.00
IUUC-Gga-040820	Gallus gallus	79.58	0.00e+00	1390.00
IUUC-Gac-041293	Gasterosteus aculeatus	85.60	0.00e+00	1448.00
IUUC-Ggo-045235	Gorilla gorilla	79.19	0.00e+00	1350.00
IUUC-Hsa-046819	Homo sapiens	81.53	0.00e+00	1396.00
IUUC-Itr-048063	Ictidomys tridecemlineatus	78.42	0.00e+00	740.00
IUUC-Lch-049443	Latimeria chalumnae	82.46	0.00e+00	1400.00
IUUC-Loc-052798	Lepisosteus oculatus	85.00	0.00e+00	1440.00
IUUC-Laf-053379	Loxodonta africana	81.62	0.00e+00	1395.00
IUUC-Mcc-055702	Macaca mulatta	81.53	0.00e+00	1395.00
IUUC-Meu-056223	Macropus eugenii	60.02	0.00e+00	900.00
IUUC-Mga-060034	Meleagris gallopavo	82.24	0.00e+00	1407.00
IUUC-Mmr-061090	Microcebus murinus	81.62	0.00e+00	1394.00
IUUC-Mdo-062530	Monodelphis domestica	81.62	0.00e+00	1393.00
IUUC-Mmu-063857	Mus musculus	80.19	0.00e+00	1352.00
IUUC-Mpu-065915	Mustela putorius furo	81.50	0.00e+00	1394.00
IUUC-Mlu-068049	Myotis lucifugus	81.41	0.00e+00	1394.00
IUUC-Nle-069102	Nomascus leucogenys	80.32	0.00e+00	1037.00
IUUC-Opr-071197	Ochotona princeps	71.75	0.00e+00	1145.00
IUUC-Ont-071902	Oreochromis niloticus	86.28	0.00e+00	1461.00
IUUC-Oan-073307	Ornithorhynchus anatinus	79.03	0.00e+00	1377.00
IUUC-Ocu-074703	Oryctolagus cuniculus	80.91	0.00e+00	1387.00
IUUC-Ola-086789	Oryzias latipes	85.97	0.00e+00	1456.00
IUUC-Oga-088480	Otolemur garnettii	81.05	0.00e+00	1384.00
IUUC-Oar-089899	Ovis aries	81.53	0.00e+00	1395.00
IUUC-Ptr-090965	Pan troglodytes	81.38	0.00e+00	1394.00
IUUC-Pan-092920	Papio anubis	78.24	0.00e+00	1326.00
IUUC-Psi-093122	Pelodiscus sinensis	81.86	0.00e+00	1389.00
IUUC-Pma-094656	Petromyzon marinus	68.30	0.00e+00	1169.00
IUUC-Pfo-096342	Poecilia formosa	86.40	0.00e+00	1461.00
IUUC-Pab-097544	Pongo abelii	81.50	0.00e+00	1395.00
IUUC-Pca-100564	Procavia capensis	76.20	0.00e+00	736.00
IUUC-Pva-102179	Pteropus vampyrus	79.68	1.00e-177	616.00
IUUC-Rno-105439	Rattus norvegicus	80.43	0.00e+00	1354.00
IUUC-Sha-106654	Sarcophilus harrisii	81.53	0.00e+00	1394.00
IUUC-Sar-113138	Sorex araneus	77.09	0.00e+00	1295.00
IUUC-Ssc-115543	Sus scrofa	77.94	0.00e+00	940.00
IUUC-Tgu-117095	Taeniopygia guttata	82.14	0.00e+00	1397.00
IUUC-Tsy-119621	Tarsius syrichta	74.50	0.00e+00	868.00
IUUC-Tni-119697	Tetraodon nigroviridis	88.08	0.00e+00	1494.00
IUUC-Tbe-127831	Tupaia belangeri	73.68	0.00e+00	1114.00
IUUC-Ttr-129108	Tursiops truncatus	81.50	0.00e+00	1394.00
IUUC-Vpa-130414	Vicugna pacos	79.44	0.00e+00	651.00
IUUC-Xtr-132054	Xenopus tropicalis	79.50	0.00e+00	1352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence