iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013523

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

F-box only protein 2

Genbank Nucleotide ID

BC118302

Gene Name

FBXO2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000007223.4	ENSBTAT00000054333.1	ENSBTAP00000048374.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	83.33	9.00e-126	446.00	IUUC-Cpo-021870
E3 adaptor/Cullin RING/SCF/F-box	88.89	8.00e-131	464.00	IUUC-Hsa-045945
E3 adaptor/Cullin RING/SCF/F-box	87.92	1.00e-121	433.00	IUUC-Mmu-064264

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity).

Protein Sequence
(Fasta)

MDGDGDPESV GQPEEASPEE QQEEACAEEA NGGEERPEDD GEGEAAYLDE LPEPLLLRVL 60
AELPAAQLVQ ACRLVCLRWK ELVDGAPLWL LKCQQEGLVP QDGPEDERDH WQQFYFLSKR 120

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Nucleotide Sequence
(Fasta)

GGGCCGCGCA CCCCGCACCC TCCGCGTGAG CCAGACTCTA CCCGCCCCCG CACCGCCTCC 60
TCCGAGCAGT CACCCCAGGA GGGCGCTGGG AGACGCCCGG AATGGGCTCC CCCTCCTCCT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0430--Lectin
KW-0472--Membrane
KW-0492--Microsome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007397--F-box-assoc_dom
IPR001810--F-box_dom
IPR008979--Galactose-bd-like

PROSITE

PS51114--FBA
PS50181--FBOX

Pfam

PF00646--F-box
PF04300--FBA

SMART

SM01198--FBA

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0031090--C:organelle membrane
GO:0019005--C:SCF ubiquitin ligase complex
GO:0030246--F:carbohydrate binding
GO:0006516--P:glycoprotein catabolic process
GO:0016567--P:protein ubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

bta:512589

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001683	Ailuropoda melanoleuca	89.90	2.00e-129	454.00
IUUC-Apl-003298	Anas platyrhynchos	69.17	1.00e-98	352.00
IUUC-Aca-005151	Anolis carolinensis	66.67	9.00e-88	316.00
IUUC-Ame-011216	Astyanax mexicanus	51.38	1.00e-58	219.00
IUUC-Cja-019449	Callithrix jacchus	93.36	1.00e-124	438.00
IUUC-Cfa-021011	Canis familiaris	93.33	6.00e-132	463.00
IUUC-Cpo-021870	Cavia porcellus	83.67	8.00e-125	439.00
IUUC-Csa-024225	Chlorocebus sabaeus	94.25	6.00e-125	439.00
IUUC-Dno-029067	Dasypus novemcinctus	92.93	1.00e-98	352.00
IUUC-Dor-030945	Dipodomys ordii	90.48	6.00e-124	436.00
IUUC-Ete-032537	Echinops telfairi	92.04	1.00e-117	415.00
IUUC-Eca-033888	Equus caballus	95.13	7.00e-127	446.00
IUUC-Eeu-034498	Erinaceus europaeus	91.36	5.00e-76	276.00
IUUC-Fca-035793	Felis catus	93.36	8.00e-124	436.00
IUUC-Fal-037415	Ficedula albicollis	68.75	8.00e-93	332.00
IUUC-Gmo-039430	Gadus morhua	59.54	1.00e-50	192.00
IUUC-Gga-040818	Gallus gallus	69.17	5.00e-99	353.00
IUUC-Ggo-045653	Gorilla gorilla	93.81	7.00e-119	419.00
IUUC-Hsa-045945	Homo sapiens	93.36	1.00e-118	418.00
IUUC-Itr-048593	Ictidomys tridecemlineatus	93.45	5.00e-125	439.00
IUUC-Lch-049839	Latimeria chalumnae	53.75	8.00e-78	283.00
IUUC-Laf-053956	Loxodonta africana	77.89	2.00e-126	444.00
IUUC-Mcc-054799	Macaca mulatta	94.25	5.00e-125	440.00
IUUC-Mtr-057935	Medicago truncatula	30.14	1.10e-01	30.40
IUUC-Mga-059915	Meleagris gallopavo	68.75	4.00e-99	353.00
IUUC-Mdo-062296	Monodelphis domestica	64.31	1.00e-104	372.00
IUUC-Mmu-064264	Mus musculus	87.50	1.00e-118	419.00
IUUC-Mpu-066032	Mustela putorius furo	93.51	5.00e-128	450.00
IUUC-Mlu-066950	Myotis lucifugus	79.67	2.00e-119	421.00
IUUC-Nle-069626	Nomascus leucogenys	88.55	2.00e-124	438.00
IUUC-Opr-070783	Ochotona princeps	90.52	4.00e-125	440.00
IUUC-Oan-073742	Ornithorhynchus anatinus	72.50	2.00e-91	328.00
IUUC-Oga-088822	Otolemur garnettii	92.11	1.00e-122	432.00
IUUC-Oar-089801	Ovis aries	97.40	2.00e-133	468.00
IUUC-Ptr-091637	Pan troglodytes	93.36	1.00e-118	418.00
IUUC-Pan-092330	Papio anubis	94.25	5.00e-125	440.00
IUUC-Psi-093974	Pelodiscus sinensis	67.92	2.00e-97	348.00
IUUC-Ppa-095869	Physcomitrella patens	22.34	2.00e-12	66.20
IUUC-Pab-097688	Pongo abelii	88.55	5.00e-125	440.00
IUUC-Pca-100828	Procavia capensis	91.95	3.00e-77	280.00
IUUC-Pva-102795	Pteropus vampyrus	93.89	2.00e-127	448.00
IUUC-Rno-106103	Rattus norvegicus	89.66	2.00e-122	431.00
IUUC-Smo-108894	Selaginella moellendorffii	20.49	3.00e-07	49.30
IUUC-Stu-112556	Solanum tuberosum	32.84	7.00e-03	33.90
IUUC-Ssc-115796	Sus scrofa	93.51	4.00e-126	443.00
IUUC-Tgu-116848	Taeniopygia guttata	69.17	1.00e-91	328.00
IUUC-Tbe-127621	Tupaia belangeri	91.52	3.00e-87	314.00
IUUC-Ttr-128809	Tursiops truncatus	92.11	7.00e-116	409.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence