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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046773
UUCD1 version UUC-HoS-01016
Ensembl Protein ID ENSP00000342434.4
UniProt Accession Q9UIG0; B9EGK3; D3DXE9; O95039; O95247; O95277; Q6P1K4; Q86UJ6; BAZ1B_HUMAN
Genbank Protein ID AAD08675.1; AAC97879.1; BAA89210.1; AAD04720.1; AAP22332.1; EAW69680.1; EAW69681.1; AAH65029.1; AAI36521.1
Protein Name Tyrosine-protein kinase BAZ1B; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2
Genbank Nucleotide ID AF084479; AF072810; AB032253; AC005074; AC005089; CH471200; CH471200; BC065029; BC136520
Gene Name BAZ1B; WBSC10; WBSCR10; WBSCR9; WSTF
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000009954.10 ENST00000339594.8 ENSP00000342434.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 6.50e-12 47.1 1185 1232
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC+++ged+ +l+ C++C+++fH  Cl ++   e+p+ e w Cp C+
   Q: 1185 ARCKVCRKKGEDD-KLILCDECNKAFHLFCLRPA-LYEVPDGE-WQCPACQ 1232
           57*********98.6*******************.*******8.******7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
 Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
Protein Sequence
(Fasta)
MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL 60
THKEAWEEEQ EVAELLKEEF PAWYEKLVLE MVHHNTASLE KLVDTAWLEI MTKYAVGEEC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046773|E3,PHD|Homo sapiens
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Nucleotide Sequence
(Fasta)
CGGGCCCGGG GGAGGAGGGG AATCTCCCGC CATTTTTCAA TAATTTCCTC CGGTGCTGCT 60
GAGGAGGAGT CGTGACTGCC GGCCGCCGGG ACCCGAAGCG GAGGTCGGCG GGGGGCTGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046773|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
KW-0856--Williams-Beuren syndrome
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR009071--HMG_box_dom
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR013136--WSTF_Acf1_Cbp146
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS51136--WAC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF00439--Bromodomain
PF00628--PHD
PF10537--WAC_Acf1_DNA_bd
PF15612--WHIM1
PF15613--WSD
PRINTS

PR00503--BROMODOMAIN
SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD
Gene Ontology

GO:0000793--C:condensed chromosome
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005721--C:pericentric heterochromatin
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035173--F:histone kinase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0071884--F:vitamin D receptor activator activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006333--P:chromatin assembly or disassembly
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0006302--P:double-strand break repair
GO:0003007--P:heart morphogenesis
GO:0016572--P:histone phosphorylation
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:9031
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002113 Ailuropoda melanoleuca 96.27 0.00e+00 2476.00
IUUC-Apl-003454 Anas platyrhynchos 79.99 0.00e+00 2157.00
IUUC-Ame-011469 Astyanax mexicanus 62.02 0.00e+00 1288.00
IUUC-Bta-012408 Bos taurus 94.67 0.00e+00 2534.00
IUUC-Cja-019194 Callithrix jacchus 97.10 0.00e+00 2613.00
IUUC-Cfa-021083 Canis familiaris 95.63 0.00e+00 2555.00
IUUC-Cpo-021422 Cavia porcellus 93.23 0.00e+00 2387.00
IUUC-Csa-023848 Chlorocebus sabaeus 99.06 0.00e+00 2675.00
IUUC-Dre-027895 Danio rerio 62.19 0.00e+00 1335.00
IUUC-Dno-029686 Dasypus novemcinctus 93.88 0.00e+00 2539.00
IUUC-Dor-030625 Dipodomys ordii 81.54 0.00e+00 1304.00
IUUC-Ete-032702 Echinops telfairi 93.21 0.00e+00 1005.00
IUUC-Eca-033647 Equus caballus 96.48 0.00e+00 2541.00
IUUC-Eeu-034626 Erinaceus europaeus 88.32 0.00e+00 2070.00
IUUC-Fca-036092 Felis catus 95.99 0.00e+00 2128.00
IUUC-Fal-037127 Ficedula albicollis 78.70 0.00e+00 2162.00
IUUC-Gmo-039455 Gadus morhua 58.33 0.00e+00 1025.00
IUUC-Gga-041120 Gallus gallus 79.26 0.00e+00 2093.00
IUUC-Gac-041873 Gasterosteus aculeatus 60.44 0.00e+00 1333.00
IUUC-Ggo-045317 Gorilla gorilla 99.86 0.00e+00 2622.00
IUUC-Itr-049026 Ictidomys tridecemlineatus 93.37 0.00e+00 2439.00
IUUC-Lch-050271 Latimeria chalumnae 69.92 0.00e+00 1663.00
IUUC-Loc-052699 Lepisosteus oculatus 65.94 0.00e+00 1036.00
IUUC-Mcc-055171 Macaca mulatta 98.99 0.00e+00 2671.00
IUUC-Meu-055990 Macropus eugenii 84.95 0.00e+00 2034.00
IUUC-Mga-059913 Meleagris gallopavo 78.77 0.00e+00 1992.00
IUUC-Mmr-061681 Microcebus murinus 95.89 0.00e+00 2570.00
IUUC-Mdo-062486 Monodelphis domestica 87.08 0.00e+00 2256.00
IUUC-Mmu-063460 Mus musculus 91.12 0.00e+00 2292.00
IUUC-Mpu-066324 Mustela putorius furo 92.91 0.00e+00 1303.00
IUUC-Mlu-067334 Myotis lucifugus 94.14 0.00e+00 2598.00
IUUC-Nle-069983 Nomascus leucogenys 99.53 0.00e+00 2713.00
IUUC-Opr-070678 Ochotona princeps 85.77 0.00e+00 759.00
IUUC-Ont-071565 Oreochromis niloticus 60.60 0.00e+00 991.00
IUUC-Ocu-074779 Oryctolagus cuniculus 94.40 0.00e+00 2427.00
IUUC-Obr-076214 Oryza brachyantha 42.47 1.00e-11 67.00
IUUC-Ola-086746 Oryzias latipes 60.20 0.00e+00 1376.00
IUUC-Oga-088475 Otolemur garnettii 91.11 0.00e+00 2461.00
IUUC-Oar-090191 Ovis aries 93.05 0.00e+00 2438.00
IUUC-Ptr-090963 Pan troglodytes 98.92 0.00e+00 2660.00
IUUC-Pan-091819 Papio anubis 98.90 0.00e+00 2097.00
IUUC-Psi-093967 Pelodiscus sinensis 81.55 0.00e+00 2069.00
IUUC-Pfo-096939 Poecilia formosa 58.45 0.00e+00 1019.00
IUUC-Pab-098679 Pongo abelii 99.21 0.00e+00 2495.00
IUUC-Pop-099061 Populus trichocarpa 65.52 5.00e-09 55.50
IUUC-Pva-102969 Pteropus vampyrus 95.36 0.00e+00 2377.00
IUUC-Rno-104927 Rattus norvegicus 91.64 0.00e+00 2328.00
IUUC-Sha-107021 Sarcophilus harrisii 84.68 0.00e+00 2095.00
IUUC-Ssc-116243 Sus scrofa 95.48 0.00e+00 2553.00
IUUC-Tgu-117073 Taeniopygia guttata 76.57 0.00e+00 1826.00
IUUC-Tru-118265 Takifugu rubripes 59.28 0.00e+00 1389.00
IUUC-Ttr-128885 Tursiops truncatus 91.80 0.00e+00 2078.00
IUUC-Vvi-131714 Vitis vinifera 50.00 2.00e-12 67.00
IUUC-Xtr-131812 Xenopus tropicalis 64.05 0.00e+00 1571.00
Created Date 25-Jun-2017

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