iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132272

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase TRIM71; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71

Genbank Nucleotide ID

AAMC01073953

Gene Name

trim71; lin41

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000005362.3	ENSXETT00000011768.3	ENSXETP00000011768.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.30e-06	28.2	12	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf......................kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+e++                      ++ ++vlpC H+f+++Cl+    ++   s + rCP+C+
   Q: 12   CPLCKEMCvstssssagsagggtglasappRR-LHVLPCLHAFCRQCLEGR--RSPGDSLQLRCPVCD 76
           ****9999999999999888888888888566.99*************444..4578999*******5 PP

Organism

Xenopus tropicalis

Functional Description
(View)

E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and participates in post-transcriptional repression of transcripts. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development.

Protein Sequence
(Fasta)

MASFPESDFQ LCPLCKEMCV STSSSSAGSA GGGTGLASAP PRRLHVLPCL HAFCRQCLEG 60
RRSPGDSLQL RCPVCDHKVL ISEAGMDALP SSTFLHLSNL LDAVVGAADE QQQSNGGRTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTTCAT TCCCGGAGTC CGATTTCCAG CTGTGCCCCC TGTGTAAGGA GATGTGCGTG 60
TCCTCTGCCC CCATCTCCTC CTCCAGCTCT TCCTCATCCT CCTCCCAGGT GTCCACCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box

SMART

SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING

Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0010172--P:embryonic body morphogenesis
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0021915--P:neural tube development
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0072089--P:stem cell proliferation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001234	Ailuropoda melanoleuca	85.05	0.00e+00	1077.00
IUUC-Apl-003905	Anas platyrhynchos	88.87	0.00e+00	1096.00
IUUC-Aca-004326	Anolis carolinensis	81.99	0.00e+00	1160.00
IUUC-Ame-011573	Astyanax mexicanus	74.12	0.00e+00	1213.00
IUUC-Bta-013395	Bos taurus	83.80	0.00e+00	1156.00
IUUC-Cel-018188	Caenorhabditis elegans	36.51	7.00e-108	385.00
IUUC-Cja-019863	Callithrix jacchus	84.03	0.00e+00	1168.00
IUUC-Cfa-020285	Canis familiaris	84.45	0.00e+00	1173.00
IUUC-Cpo-021879	Cavia porcellus	74.89	0.00e+00	1268.00
IUUC-Csa-024271	Chlorocebus sabaeus	84.03	0.00e+00	1164.00
IUUC-Cho-024376	Choloepus hoffmanni	86.99	0.00e+00	1068.00
IUUC-Cin-025406	Ciona intestinalis	48.53	0.00e+00	632.00
IUUC-Dre-027699	Danio rerio	74.18	0.00e+00	1219.00
IUUC-Dno-029022	Dasypus novemcinctus	86.67	0.00e+00	1070.00
IUUC-Dor-031072	Dipodomys ordii	73.52	0.00e+00	1242.00
IUUC-Dme-031997	Drosophila melanogaster	47.64	1.00e-70	261.00
IUUC-Ete-032228	Echinops telfairi	88.28	0.00e+00	754.00
IUUC-Eca-033373	Equus caballus	87.74	0.00e+00	951.00
IUUC-Eeu-034463	Erinaceus europaeus	87.10	0.00e+00	1040.00
IUUC-Fca-036184	Felis catus	86.13	0.00e+00	1079.00
IUUC-Fal-036918	Ficedula albicollis	77.99	0.00e+00	1104.00
IUUC-Fox-038003	Fusarium oxysporum	32.20	6.00e-04	37.70
IUUC-Gmo-039415	Gadus morhua	69.49	0.00e+00	855.00
IUUC-Gga-040379	Gallus gallus	84.67	0.00e+00	1190.00
IUUC-Gac-042330	Gasterosteus aculeatus	64.76	0.00e+00	1046.00
IUUC-Gma-043819	Glycine max	24.85	3.00e-13	71.20
IUUC-Ggo-045208	Gorilla gorilla	84.18	0.00e+00	1163.00
IUUC-Hsa-045988	Homo sapiens	84.18	0.00e+00	1165.00
IUUC-Itr-048371	Ictidomys tridecemlineatus	87.52	0.00e+00	1078.00
IUUC-Lch-050324	Latimeria chalumnae	74.53	0.00e+00	1243.00
IUUC-Loc-052322	Lepisosteus oculatus	76.09	0.00e+00	1280.00
IUUC-Laf-054272	Loxodonta africana	82.99	0.00e+00	1132.00
IUUC-Mcc-055125	Macaca mulatta	84.03	0.00e+00	1164.00
IUUC-Meu-055934	Macropus eugenii	77.96	0.00e+00	1057.00
IUUC-Mga-059930	Meleagris gallopavo	88.21	0.00e+00	1088.00
IUUC-Mmr-060662	Microcebus murinus	83.78	0.00e+00	1161.00
IUUC-Mdo-062918	Monodelphis domestica	82.60	0.00e+00	1185.00
IUUC-Mmu-064351	Mus musculus	73.17	0.00e+00	1234.00
IUUC-Mpu-066325	Mustela putorius furo	86.96	0.00e+00	949.00
IUUC-Mlu-067171	Myotis lucifugus	70.96	0.00e+00	1194.00
IUUC-Nle-069692	Nomascus leucogenys	84.03	0.00e+00	1164.00
IUUC-Opr-070354	Ochotona princeps	85.79	0.00e+00	1061.00
IUUC-Ont-072125	Oreochromis niloticus	69.44	0.00e+00	1157.00
IUUC-Oan-073079	Ornithorhynchus anatinus	88.38	0.00e+00	1089.00
IUUC-Ocu-073910	Oryctolagus cuniculus	75.18	0.00e+00	1237.00
IUUC-Ola-087162	Oryzias latipes	70.53	0.00e+00	1165.00
IUUC-Oga-088523	Otolemur garnettii	71.10	0.00e+00	1170.00
IUUC-Oar-090009	Ovis aries	84.93	8.00e-176	608.00
IUUC-Ptr-091173	Pan troglodytes	84.18	0.00e+00	1166.00
IUUC-Pan-091750	Papio anubis	83.90	0.00e+00	1160.00
IUUC-Psi-093053	Pelodiscus sinensis	84.10	0.00e+00	1033.00
IUUC-Pma-094227	Petromyzon marinus	58.71	4.00e-174	603.00
IUUC-Pfo-096980	Poecilia formosa	66.47	0.00e+00	1105.00
IUUC-Pab-098189	Pongo abelii	84.60	0.00e+00	1170.00
IUUC-Pva-103126	Pteropus vampyrus	83.51	0.00e+00	1152.00
IUUC-Rno-105653	Rattus norvegicus	73.75	0.00e+00	1241.00
IUUC-Sha-107178	Sarcophilus harrisii	88.34	0.00e+00	1090.00
IUUC-Sly-111723	Solanum lycopersicum	34.78	2.00e-03	37.70
IUUC-Stu-112510	Solanum tuberosum	31.52	8.00e-07	46.60
IUUC-Sar-113613	Sorex araneus	76.86	0.00e+00	893.00
IUUC-Tgu-116963	Taeniopygia guttata	87.69	0.00e+00	1087.00
IUUC-Tru-117942	Takifugu rubripes	71.20	0.00e+00	1163.00
IUUC-Tsy-119075	Tarsius syrichta	79.97	0.00e+00	960.00
IUUC-Tni-120704	Tetraodon nigroviridis	79.52	0.00e+00	993.00
IUUC-Tbe-128141	Tupaia belangeri	69.56	0.00e+00	732.00
IUUC-Ttr-128908	Tursiops truncatus	76.16	1.00e-175	609.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence