iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061907

Ensembl Protein ID

ENSMODP00000014693.3

UniProt Accession

F7FSS6; F7FSS6_MONDO

Protein Name

Uncharacterized protein

Gene Name

OTUD7A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000011729.3	ENSMODT00000014964.3	ENSMODP00000014693.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.30e-40	138.4	201	382
UBD/ZnF/ZnF_A20	1.60e-14	53.7	893	924

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k           e+e++++ kl+++e    
   Q: 201  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRSGAEREALKRRWRWQQTQQNKesglvyteeewEREWNELLKLASSEprth 289
           6899*********************************************************************************8877 PP
   S: 75   .ak.g.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYda 134
            +k g                 ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++a
   Q: 290  fSKnGgtgggvdnsedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSA 378
           7444377899******************************************************************************* PP
   S: 135  Lval 138
           Lv++
   Q: 379  LVSM 382
           *986 PP

UBD/ZnF/ZnF_A20

   S: 4    kllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           + +Ckk +C+fYG+pet++yCS+Cy+eel+rr
   Q: 893  QNRCKKeNCSFYGRPETENYCSYCYKEELKRR 924
           78*****************************9 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MASSLLLNPT SAECWAALLH DHMTLDMDAV LSDFVRSTGA EPGLARDLLE GKNWDLTAAL 60
SDYEQLRQVH TANLPQVFNE GKYYKQPERE PSQQVNKVER PCLQRQDDIA QEKRLSRGIS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGACAGT GTCTCCTAGA GGACTGCTAT CAATTCTGCA GTTTCCATCA GAAGTTGTGC 60
TTAGTGATGT CTGGACACCA AATGGAAATC ACTGTTGCTG AAGTAAATAA CTAGCAGTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

KEGG

mdo:100021938

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001551	Ailuropoda melanoleuca	92.27	0.00e+00	985.00
IUUC-Apl-003825	Anas platyrhynchos	82.91	0.00e+00	1415.00
IUUC-Aca-004392	Anolis carolinensis	93.34	0.00e+00	1528.00
IUUC-Ame-011052	Astyanax mexicanus	78.11	0.00e+00	1278.00
IUUC-Bta-013296	Bos taurus	76.60	0.00e+00	1102.00
IUUC-Cja-019141	Callithrix jacchus	89.42	0.00e+00	1036.00
IUUC-Cfa-020447	Canis familiaris	91.68	0.00e+00	1067.00
IUUC-Cpo-022059	Cavia porcellus	95.48	0.00e+00	943.00
IUUC-Csa-023263	Chlorocebus sabaeus	92.69	0.00e+00	1074.00
IUUC-Cho-024611	Choloepus hoffmanni	85.55	3.00e-165	575.00
IUUC-Csv-026177	Ciona savignyi	29.76	8.00e-03	33.50
IUUC-Dre-028617	Danio rerio	75.77	0.00e+00	1267.00
IUUC-Dno-029121	Dasypus novemcinctus	86.36	0.00e+00	1004.00
IUUC-Ete-033068	Echinops telfairi	83.12	0.00e+00	937.00
IUUC-Eca-034413	Equus caballus	92.34	0.00e+00	1031.00
IUUC-Fca-036487	Felis catus	87.30	0.00e+00	948.00
IUUC-Fal-037145	Ficedula albicollis	92.66	0.00e+00	1522.00
IUUC-Gmo-038786	Gadus morhua	65.99	0.00e+00	1083.00
IUUC-Gga-040512	Gallus gallus	90.17	0.00e+00	1469.00
IUUC-Gac-041599	Gasterosteus aculeatus	73.74	0.00e+00	1199.00
IUUC-Ggo-044819	Gorilla gorilla	77.60	0.00e+00	1123.00
IUUC-Hsa-046781	Homo sapiens	78.19	0.00e+00	1196.00
IUUC-Lch-050666	Latimeria chalumnae	89.04	0.00e+00	1439.00
IUUC-Loc-052841	Lepisosteus oculatus	92.58	0.00e+00	932.00
IUUC-Laf-053437	Loxodonta africana	84.94	0.00e+00	1037.00
IUUC-Mcc-055353	Macaca mulatta	77.99	0.00e+00	1187.00
IUUC-Mga-059741	Meleagris gallopavo	85.53	0.00e+00	1421.00
IUUC-Mmr-061437	Microcebus murinus	77.41	0.00e+00	1231.00
IUUC-Mmu-064074	Mus musculus	77.40	0.00e+00	1174.00
IUUC-Mpu-066004	Mustela putorius furo	90.66	0.00e+00	983.00
IUUC-Nle-069182	Nomascus leucogenys	87.58	0.00e+00	1077.00
IUUC-Opr-070701	Ochotona princeps	80.09	0.00e+00	845.00
IUUC-Ont-072431	Oreochromis niloticus	88.82	0.00e+00	878.00
IUUC-Oan-073235	Ornithorhynchus anatinus	78.92	0.00e+00	1206.00
IUUC-Ocu-073935	Oryctolagus cuniculus	90.83	0.00e+00	1005.00
IUUC-Ola-087026	Oryzias latipes	75.54	0.00e+00	1292.00
IUUC-Oga-088249	Otolemur garnettii	91.50	0.00e+00	1083.00
IUUC-Oar-089476	Ovis aries	77.42	0.00e+00	1201.00
IUUC-Ptr-090548	Pan troglodytes	92.06	0.00e+00	980.00
IUUC-Pan-092616	Papio anubis	78.63	0.00e+00	1149.00
IUUC-Psi-093126	Pelodiscus sinensis	95.58	0.00e+00	1555.00
IUUC-Pfo-096785	Poecilia formosa	87.84	0.00e+00	881.00
IUUC-Pab-098336	Pongo abelii	81.24	0.00e+00	1110.00
IUUC-Pca-100206	Procavia capensis	71.82	0.00e+00	989.00
IUUC-Rno-105483	Rattus norvegicus	73.94	0.00e+00	845.00
IUUC-Sha-106617	Sarcophilus harrisii	92.38	0.00e+00	979.00
IUUC-Ssc-115415	Sus scrofa	75.53	0.00e+00	1044.00
IUUC-Tgu-117218	Taeniopygia guttata	91.11	0.00e+00	1107.00
IUUC-Tru-118720	Takifugu rubripes	85.55	0.00e+00	851.00
IUUC-Tni-120795	Tetraodon nigroviridis	88.04	0.00e+00	866.00
IUUC-Xtr-132158	Xenopus tropicalis	87.77	0.00e+00	1509.00
IUUC-Xma-133941	Xiphophorus maculatus	84.12	0.00e+00	843.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence