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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046569
Ensembl Protein ID ENSP00000308759.5
UniProt Accession Q9ULJ3; Q5R2W1; Q5R2W2; Q6P4R0; ZBT21_HUMAN
Genbank Protein ID BAD74063.1; BAD74064.1; BAA86541.1; BAA95529.1; EAX09579.1; EAX09580.1; EAX09581.1; AAH63290.1
Protein Name Zinc finger and BTB domain-containing protein 21; Zinc finger protein 295
Genbank Nucleotide ID AB041014; AB041015; AB033053; AP001745; CH471079; CH471079; CH471079; BC063290
Gene Name ZBTB21; KIAA1227; ZNF295
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000173276.13 ENST00000398505.7 ENSP00000381517.3
ENSG00000173276.13 ENST00000310826.9 ENSP00000308759.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.20e-16 61.1 30 92
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikd.vqpevfrallkFlYtgkl 65
           +Dv+l+vg+++f+ahk vLaasS++F++lf+++ +es+     ++ d  +p++f  +l+++Y+++l
   Q: 30   CDVLLIVGDQKFRAHKNVLAASSEYFQSLFTNKENESQ--TVFQL-DfCEPDAFDNVLNYIYSSSL 92
           8*******************************999996..55555.55**************9987 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a transcription repressor.
 Acts as a transcription repressor.
Protein Sequence
(Fasta)
MEGLLHYINP AHAISLLSAL NEERLKGQLC DVLLIVGDQK FRAHKNVLAA SSEYFQSLFT 60
NKENESQTVF QLDFCEPDAF DNVLNYIYSS SLFVEKSSLA AVQELGYSLG ISFLTNIVSK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046569|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGATGACCT CATCCCTGGT GTGGGATGAC GTCAAATTCA AGATGGATGG AATCACAGCG 60
GCAGCGGCGG CTGCGGCGCG CGCGAGCCGA GTGTGAGCGG AAAGGGGCCC GGCGTCTGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046569|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:49854
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-004216 Anas platyrhynchos 79.83 0.00e+00 1617.00
IUUC-Aca-005330 Anolis carolinensis 74.20 0.00e+00 1500.00
IUUC-Ame-011710 Astyanax mexicanus 47.00 0.00e+00 810.00
IUUC-Bta-012930 Bos taurus 64.61 0.00e+00 707.00
IUUC-Cja-019057 Callithrix jacchus 97.19 0.00e+00 1939.00
IUUC-Cpo-022202 Cavia porcellus 69.63 0.00e+00 768.00
IUUC-Csa-023030 Chlorocebus sabaeus 99.25 0.00e+00 1958.00
IUUC-Cho-024582 Choloepus hoffmanni 88.90 0.00e+00 1552.00
IUUC-Dre-028649 Danio rerio 71.43 3.00e-52 197.00
IUUC-Dno-029152 Dasypus novemcinctus 87.45 0.00e+00 1324.00
IUUC-Ete-032232 Echinops telfairi 78.61 0.00e+00 944.00
IUUC-Eca-033606 Equus caballus 82.15 0.00e+00 880.00
IUUC-Fca-036242 Felis catus 84.05 0.00e+00 1690.00
IUUC-Fal-037536 Ficedula albicollis 76.70 0.00e+00 1452.00
IUUC-Gmo-039404 Gadus morhua 44.90 0.00e+00 761.00
IUUC-Gga-040500 Gallus gallus 76.50 0.00e+00 1548.00
IUUC-Gac-041336 Gasterosteus aculeatus 47.27 0.00e+00 824.00
IUUC-Ggo-044746 Gorilla gorilla 99.62 0.00e+00 1961.00
IUUC-Itr-048734 Ictidomys tridecemlineatus 89.77 0.00e+00 1739.00
IUUC-Lch-049452 Latimeria chalumnae 66.73 0.00e+00 1266.00
IUUC-Loc-052553 Lepisosteus oculatus 49.95 0.00e+00 913.00
IUUC-Laf-053872 Loxodonta africana 90.25 0.00e+00 1807.00
IUUC-Mcc-055696 Macaca mulatta 99.16 0.00e+00 1956.00
IUUC-Mga-059982 Meleagris gallopavo 79.49 0.00e+00 1560.00
IUUC-Mmr-061699 Microcebus murinus 94.93 0.00e+00 1842.00
IUUC-Mmu-063794 Mus musculus 86.34 0.00e+00 1717.00
IUUC-Mpu-065965 Mustela putorius furo 72.73 0.00e+00 804.00
IUUC-Mlu-067014 Myotis lucifugus 87.99 0.00e+00 1745.00
IUUC-Nle-069504 Nomascus leucogenys 90.40 0.00e+00 1009.00
IUUC-Opr-070893 Ochotona princeps 75.21 5.00e-179 621.00
IUUC-Ont-071602 Oreochromis niloticus 49.54 5.00e-157 548.00
IUUC-Ocu-074153 Oryctolagus cuniculus 72.05 0.00e+00 752.00
IUUC-Ola-087382 Oryzias latipes 52.01 2.00e-87 317.00
IUUC-Oga-088259 Otolemur garnettii 94.00 0.00e+00 1865.00
IUUC-Ptr-091288 Pan troglodytes 99.72 0.00e+00 1967.00
IUUC-Pan-092536 Papio anubis 90.40 0.00e+00 977.00
IUUC-Psi-093023 Pelodiscus sinensis 81.05 0.00e+00 1598.00
IUUC-Pno-095006 Phaeosphaeria nodorum 25.76 3.00e-06 45.80
IUUC-Pfo-096863 Poecilia formosa 46.10 0.00e+00 797.00
IUUC-Pab-098287 Pongo abelii 95.03 0.00e+00 1833.00
IUUC-Pca-100251 Procavia capensis 89.33 0.00e+00 1293.00
IUUC-Rno-105630 Rattus norvegicus 75.42 0.00e+00 808.00
IUUC-Sha-107002 Sarcophilus harrisii 81.52 0.00e+00 1647.00
IUUC-Ssc-115347 Sus scrofa 67.07 0.00e+00 1170.00
IUUC-Tgu-116955 Taeniopygia guttata 77.59 0.00e+00 1560.00
IUUC-Tru-118689 Takifugu rubripes 44.43 0.00e+00 773.00
IUUC-Tsy-119628 Tarsius syrichta 93.91 0.00e+00 1821.00
IUUC-Tni-120309 Tetraodon nigroviridis 48.75 2.00e-80 293.00
IUUC-Ttr-128865 Tursiops truncatus 69.26 0.00e+00 1279.00
Created Date 25-Jun-2017

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