iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055447

Ensembl Protein ID

ENSMMUP00000010063.2

UniProt Accession

F7DBZ3; F7DBZ3_MACMU

Genbank Protein ID

AFE65401.1; EHH20928.1

Protein Name

Serine/threonine-protein kinase TBK1

Genbank Nucleotide ID

JSUE03007092; CM001263

Gene Name

TBK1; EGK_03880

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000007658.3	ENSMMUT00000010727.3	ENSMMUP00000010063.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	94.24	0.00e+00	1461.00	IUUC-Mmu-064107

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK 60
KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGGGCTCG AGGCCGCGGG AGCCCGCCGG CGGTGGCGCG GCGGAGACCC GGCTGGGTAA 60
GTGAGACGGC CGCGGGCGGA GGGGCCGAGG CGGCGCGGGG CGCGGTCGGT CAGGCCTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0003676--F:nucleic acid binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0002218--P:activation of innate immune response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0044565--P:dendritic cell proliferation
GO:0045087--P:innate immune response
GO:0010629--P:negative regulation of gene expression
GO:0018105--P:peptidyl-serine phosphorylation
GO:0018107--P:peptidyl-threonine phosphorylation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032727--P:positive regulation of interferon-alpha production
GO:0045359--P:positive regulation of interferon-beta biosynthetic process
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1904417--P:positive regulation of xenophagy

KEGG

mcc:717427

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001638	Ailuropoda melanoleuca	97.53	0.00e+00	1493.00
IUUC-Apl-004028	Anas platyrhynchos	87.52	0.00e+00	1362.00
IUUC-Aca-004998	Anolis carolinensis	82.72	0.00e+00	1291.00
IUUC-Ame-011617	Astyanax mexicanus	71.03	0.00e+00	1070.00
IUUC-Bta-012799	Bos taurus	97.12	0.00e+00	1490.00
IUUC-Cja-019357	Callithrix jacchus	98.90	0.00e+00	1505.00
IUUC-Cfa-020309	Canis familiaris	96.98	0.00e+00	1486.00
IUUC-Cpo-022062	Cavia porcellus	96.71	0.00e+00	1477.00
IUUC-Csa-023517	Chlorocebus sabaeus	99.86	0.00e+00	1519.00
IUUC-Cho-025037	Choloepus hoffmanni	94.14	0.00e+00	980.00
IUUC-Cin-025580	Ciona intestinalis	40.60	7.00e-150	524.00
IUUC-Csv-025818	Ciona savignyi	40.40	9.00e-145	507.00
IUUC-Dre-027527	Danio rerio	71.39	0.00e+00	1089.00
IUUC-Dno-029475	Dasypus novemcinctus	84.76	0.00e+00	1132.00
IUUC-Dme-031698	Drosophila melanogaster	39.47	3.00e-133	469.00
IUUC-Ete-033090	Echinops telfairi	83.26	0.00e+00	1235.00
IUUC-Eca-033996	Equus caballus	95.20	0.00e+00	1471.00
IUUC-Eeu-035082	Erinaceus europaeus	88.28	0.00e+00	866.00
IUUC-Fca-035921	Felis catus	94.13	0.00e+00	1432.00
IUUC-Fal-037406	Ficedula albicollis	87.38	0.00e+00	1366.00
IUUC-Gmo-038721	Gadus morhua	71.19	0.00e+00	1056.00
IUUC-Gga-041234	Gallus gallus	86.83	0.00e+00	1359.00
IUUC-Gac-042315	Gasterosteus aculeatus	71.72	0.00e+00	1073.00
IUUC-Ggo-044885	Gorilla gorilla	92.59	0.00e+00	1395.00
IUUC-Hsa-046847	Homo sapiens	99.04	0.00e+00	1513.00
IUUC-Itr-047906	Ictidomys tridecemlineatus	96.60	0.00e+00	1478.00
IUUC-Lch-049731	Latimeria chalumnae	54.62	0.00e+00	783.00
IUUC-Loc-051879	Lepisosteus oculatus	73.08	0.00e+00	1112.00
IUUC-Laf-054232	Loxodonta africana	95.62	0.00e+00	1469.00
IUUC-Meu-056138	Macropus eugenii	96.98	0.00e+00	684.00
IUUC-Mga-059460	Meleagris gallopavo	85.64	0.00e+00	1332.00
IUUC-Mmr-061445	Microcebus murinus	98.08	0.00e+00	1498.00
IUUC-Mmu-064107	Mus musculus	94.24	0.00e+00	1436.00
IUUC-Mpu-066834	Mustela putorius furo	97.67	0.00e+00	1497.00
IUUC-Mlu-068006	Myotis lucifugus	93.15	0.00e+00	1406.00
IUUC-Nle-069280	Nomascus leucogenys	98.90	0.00e+00	1511.00
IUUC-Opr-070728	Ochotona princeps	89.43	0.00e+00	1205.00
IUUC-Ont-071621	Oreochromis niloticus	72.74	0.00e+00	1088.00
IUUC-Oan-073162	Ornithorhynchus anatinus	91.71	0.00e+00	1373.00
IUUC-Ocu-074787	Oryctolagus cuniculus	97.81	0.00e+00	1496.00
IUUC-Ola-086737	Oryzias latipes	33.48	3.00e-28	120.00
IUUC-Oga-088764	Otolemur garnettii	95.20	0.00e+00	1467.00
IUUC-Oar-090333	Ovis aries	96.85	0.00e+00	1482.00
IUUC-Ptr-090568	Pan troglodytes	98.63	0.00e+00	1509.00
IUUC-Pan-091979	Papio anubis	99.73	0.00e+00	1512.00
IUUC-Psi-093336	Pelodiscus sinensis	87.24	0.00e+00	1348.00
IUUC-Pma-094200	Petromyzon marinus	44.48	5.00e-177	614.00
IUUC-Pfo-096354	Poecilia formosa	71.82	0.00e+00	1083.00
IUUC-Pab-098499	Pongo abelii	98.90	0.00e+00	1513.00
IUUC-Pva-102454	Pteropus vampyrus	95.61	0.00e+00	1448.00
IUUC-Rno-105595	Rattus norvegicus	94.51	0.00e+00	1436.00
IUUC-Sha-106864	Sarcophilus harrisii	93.58	0.00e+00	1449.00
IUUC-Sar-113728	Sorex araneus	88.29	0.00e+00	1268.00
IUUC-Tgu-117200	Taeniopygia guttata	86.34	0.00e+00	1348.00
IUUC-Tsy-119017	Tarsius syrichta	96.88	0.00e+00	1106.00
IUUC-Tni-120724	Tetraodon nigroviridis	71.07	0.00e+00	1074.00
IUUC-Tbe-127887	Tupaia belangeri	87.54	0.00e+00	1048.00
IUUC-Ttr-129111	Tursiops truncatus	89.71	0.00e+00	1349.00
IUUC-Vpa-130724	Vicugna pacos	97.81	0.00e+00	1494.00
IUUC-Xtr-132091	Xenopus tropicalis	75.10	0.00e+00	1172.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence