iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069693

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01081407

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000000049.2	ENSNLET00000000091.1	ENSNLEP00000000083.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-80	269.9	3862	4222

Active Site

Position(s)	Description	Evidence
4196	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe+++++G++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3862 DPTYAFNIRFTGEEVHGTSGSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3944
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelyks.lkeikenaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y++ +k+ + n+e+++e+l+++++++  +  ++                 + 
   Q: 3945 ADVPLPLDLLPSFWKMLVGEPLDPeQDLQEADILTYNYvKKFESINDETELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 4029
           ************************9*************56666677789999999999999532..33468999*******655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++i V++eNk+ Y  ++ ++rl+e +  e+v+a+r+G+ ++ipl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 4030 EEVELCSRGRHILVAWENKDIYAAAIRSLRLRElQNVECVTAVRAGLGSIIPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 4116
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f++ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 4117 GLMETDQHIEFFWGALEMFTQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 4203
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 4204 QYSSLEIMLEKLRCAIHYR 4222
           ****************986 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGLLLVFPLI QSQSRTDPSL CNITAEVLLN CLRDCQPLSL TKEPADCLNG IETLLCSWLE 60
ETSDTGRHIP HKQKENAAAA LVALACARGS LKTFVHTVHL LQKQTDLGSL PVADVLYRLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCTCC TGCTGGTCTT CCCCCTTATT CAGTCCCAGA GTAGAACAGA CCCCTCTCTC 60
TGTAACATAA CTGCTGAGGT GCTATTGAAC TGCCTTCGTG ACTGCCAGCC TTTGAGCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	96.33	0.00e+00	7140.00
IUUC-Apl-004161	Anas platyrhynchos	90.82	0.00e+00	5067.00
IUUC-Aca-005341	Anolis carolinensis	88.35	0.00e+00	6549.00
IUUC-Ame-011574	Astyanax mexicanus	78.63	0.00e+00	4682.00
IUUC-Bta-012514	Bos taurus	96.64	0.00e+00	1939.00
IUUC-Cja-019148	Callithrix jacchus	96.40	0.00e+00	5223.00
IUUC-Cfa-020499	Canis familiaris	95.41	0.00e+00	7561.00
IUUC-Cpo-021894	Cavia porcellus	93.97	0.00e+00	2652.00
IUUC-Csa-023079	Chlorocebus sabaeus	96.83	0.00e+00	7678.00
IUUC-Cho-024415	Choloepus hoffmanni	92.38	0.00e+00	4986.00
IUUC-Dre-027452	Danio rerio	76.98	0.00e+00	4660.00
IUUC-Dno-029595	Dasypus novemcinctus	94.63	0.00e+00	7541.00
IUUC-Dor-030849	Dipodomys ordii	96.69	0.00e+00	1790.00
IUUC-Ete-032563	Echinops telfairi	89.30	0.00e+00	1621.00
IUUC-Eca-034202	Equus caballus	96.48	0.00e+00	7095.00
IUUC-Eeu-035175	Erinaceus europaeus	96.93	0.00e+00	1071.00
IUUC-Fca-036295	Felis catus	94.78	0.00e+00	6904.00
IUUC-Fal-037003	Ficedula albicollis	90.24	0.00e+00	6530.00
IUUC-Gmo-038579	Gadus morhua	81.76	0.00e+00	2742.00
IUUC-Gga-040961	Gallus gallus	90.64	0.00e+00	7304.00
IUUC-Gac-041899	Gasterosteus aculeatus	81.48	0.00e+00	2776.00
IUUC-Ggo-045099	Gorilla gorilla	97.95	0.00e+00	6397.00
IUUC-Hsa-046331	Homo sapiens	97.30	0.00e+00	7761.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	95.92	0.00e+00	2163.00
IUUC-Lch-049923	Latimeria chalumnae	86.39	0.00e+00	2664.00
IUUC-Loc-052630	Lepisosteus oculatus	82.02	0.00e+00	3921.00
IUUC-Laf-053394	Loxodonta africana	94.64	0.00e+00	7400.00
IUUC-Mcc-055763	Macaca mulatta	96.83	0.00e+00	7667.00
IUUC-Meu-056039	Macropus eugenii	87.97	0.00e+00	3542.00
IUUC-Mga-059500	Meleagris gallopavo	91.10	0.00e+00	6871.00
IUUC-Mmr-060868	Microcebus murinus	92.43	0.00e+00	7333.00
IUUC-Mdo-062772	Monodelphis domestica	92.03	0.00e+00	7400.00
IUUC-Mmu-063606	Mus musculus	94.38	0.00e+00	7544.00
IUUC-Mpu-065860	Mustela putorius furo	94.19	0.00e+00	6988.00
IUUC-Mlu-067376	Myotis lucifugus	96.12	0.00e+00	5272.00
IUUC-Opr-071065	Ochotona princeps	94.87	0.00e+00	1219.00
IUUC-Ont-072470	Oreochromis niloticus	81.52	0.00e+00	4536.00
IUUC-Oan-073693	Ornithorhynchus anatinus	90.71	0.00e+00	5103.00
IUUC-Ocu-074032	Oryctolagus cuniculus	94.53	0.00e+00	7587.00
IUUC-Ola-087433	Oryzias latipes	78.49	0.00e+00	1466.00
IUUC-Oga-088546	Otolemur garnettii	96.76	0.00e+00	6871.00
IUUC-Oar-089643	Ovis aries	91.65	0.00e+00	760.00
IUUC-Ptr-090504	Pan troglodytes	98.10	0.00e+00	7305.00
IUUC-Pan-092543	Papio anubis	96.72	0.00e+00	7661.00
IUUC-Psi-093952	Pelodiscus sinensis	89.35	0.00e+00	6769.00
IUUC-Pfo-096356	Poecilia formosa	78.59	0.00e+00	6415.00
IUUC-Pab-098240	Pongo abelii	96.95	0.00e+00	7670.00
IUUC-Pca-100994	Procavia capensis	94.21	0.00e+00	2884.00
IUUC-Pva-102263	Pteropus vampyrus	94.95	0.00e+00	7025.00
IUUC-Rno-104888	Rattus norvegicus	94.19	0.00e+00	7282.00
IUUC-Sha-106944	Sarcophilus harrisii	92.27	0.00e+00	6996.00
IUUC-Sar-113556	Sorex araneus	86.80	0.00e+00	966.00
IUUC-Ssc-116187	Sus scrofa	95.96	0.00e+00	5058.00
IUUC-Tgu-116655	Taeniopygia guttata	90.70	0.00e+00	5029.00
IUUC-Tru-118093	Takifugu rubripes	80.75	0.00e+00	2880.00
IUUC-Tni-119739	Tetraodon nigroviridis	78.69	0.00e+00	1493.00
IUUC-Tbe-127962	Tupaia belangeri	92.09	0.00e+00	1217.00
IUUC-Ttr-128819	Tursiops truncatus	92.65	0.00e+00	2875.00
IUUC-Vpa-130482	Vicugna pacos	93.72	0.00e+00	4356.00
IUUC-Xtr-132222	Xenopus tropicalis	85.91	0.00e+00	6516.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence