iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060190

UUCD1 version

UUC-MeG-00407

Ensembl Protein ID

ENSMGAP00000008975.1

UniProt Accession

G1N999; G1N999_MELGA

Protein Name

E3 ubiquitin-protein ligase

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000008685.1	ENSMGAT00000009787.1	ENSMGAP00000008975.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.90e-136	452.6	585	917

Active Site

Position(s)	Description	Evidence
886	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 585  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 672
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 673  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIIWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 758
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 759  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 846
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 847  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 917
           *********************************************************************96 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MASASSSRAR AGPPCEKSQL SVKVVSVKPK AHSRQSRMNC YVEVAGDGLP SETKKTGKQM 60
GSSELLWNEI LILNVTAQSH LDLKVWSCHT LRNELLGTAS VSLWNLLKSG GKLENRQLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCCAGGCC AGGGGTGATG ACATGGCCTC TGCGAGCTCC AGCAGGGCCA GGGCAGGGCC 60
ACCCTGCGAG AAGTCCCAGC TCTCTGTGAA AGGTGAGTCC TGTGCAGGGC TGGGAGCTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	79.96	0.00e+00	1436.00
IUUC-Apl-003912	Anas platyrhynchos	74.27	0.00e+00	1246.00
IUUC-Aca-004291	Anolis carolinensis	77.78	0.00e+00	1406.00
IUUC-Bta-013231	Bos taurus	79.58	0.00e+00	1417.00
IUUC-Cja-019455	Callithrix jacchus	79.76	0.00e+00	1453.00
IUUC-Cfa-021017	Canis familiaris	80.24	0.00e+00	1437.00
IUUC-Cpo-021988	Cavia porcellus	79.48	0.00e+00	1447.00
IUUC-Csa-023549	Chlorocebus sabaeus	79.19	0.00e+00	1449.00
IUUC-Dre-028513	Danio rerio	93.17	0.00e+00	1152.00
IUUC-Dno-028976	Dasypus novemcinctus	80.93	0.00e+00	1450.00
IUUC-Dor-030176	Dipodomys ordii	77.80	0.00e+00	1353.00
IUUC-Eca-033949	Equus caballus	80.49	0.00e+00	1435.00
IUUC-Eeu-034529	Erinaceus europaeus	82.17	0.00e+00	1039.00
IUUC-Fca-036236	Felis catus	80.13	0.00e+00	1450.00
IUUC-Fal-036948	Ficedula albicollis	85.12	0.00e+00	1449.00
IUUC-Gmo-038842	Gadus morhua	89.95	0.00e+00	1077.00
IUUC-Gga-040617	Gallus gallus	96.60	0.00e+00	1702.00
IUUC-Gac-041338	Gasterosteus aculeatus	72.17	0.00e+00	1275.00
IUUC-Ggo-045278	Gorilla gorilla	79.41	0.00e+00	1457.00
IUUC-Hsa-046148	Homo sapiens	79.41	0.00e+00	1459.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	95.34	0.00e+00	1089.00
IUUC-Lch-050663	Latimeria chalumnae	74.09	0.00e+00	1362.00
IUUC-Loc-052604	Lepisosteus oculatus	73.00	0.00e+00	1302.00
IUUC-Laf-053944	Loxodonta africana	80.35	0.00e+00	1444.00
IUUC-Mcc-055655	Macaca mulatta	79.19	0.00e+00	1451.00
IUUC-Meu-055953	Macropus eugenii	71.54	0.00e+00	1268.00
IUUC-Mmr-060896	Microcebus murinus	80.13	0.00e+00	1439.00
IUUC-Mdo-062536	Monodelphis domestica	81.65	0.00e+00	1489.00
IUUC-Mmu-064017	Mus musculus	79.32	0.00e+00	1432.00
IUUC-Mpu-066608	Mustela putorius furo	77.97	0.00e+00	1379.00
IUUC-Mlu-067623	Myotis lucifugus	78.61	0.00e+00	1398.00
IUUC-Nle-069496	Nomascus leucogenys	77.44	0.00e+00	1411.00
IUUC-Opr-071054	Ochotona princeps	95.41	0.00e+00	1157.00
IUUC-Ont-071279	Oreochromis niloticus	89.05	0.00e+00	1115.00
IUUC-Oan-073512	Ornithorhynchus anatinus	78.11	0.00e+00	1402.00
IUUC-Ocu-074271	Oryctolagus cuniculus	79.71	0.00e+00	1428.00
IUUC-Ola-087237	Oryzias latipes	71.74	0.00e+00	1263.00
IUUC-Oga-088164	Otolemur garnettii	80.60	0.00e+00	1445.00
IUUC-Oar-089698	Ovis aries	79.80	0.00e+00	1419.00
IUUC-Ptr-091306	Pan troglodytes	78.09	0.00e+00	1426.00
IUUC-Pan-092814	Papio anubis	75.96	0.00e+00	1362.00
IUUC-Pfo-096709	Poecilia formosa	90.66	0.00e+00	1095.00
IUUC-Pab-098494	Pongo abelii	77.89	0.00e+00	1431.00
IUUC-Pop-099613	Populus trichocarpa	44.08	3.00e-93	337.00
IUUC-Pca-100596	Procavia capensis	77.34	0.00e+00	1061.00
IUUC-Pva-103154	Pteropus vampyrus	84.74	0.00e+00	1149.00
IUUC-Rno-104954	Rattus norvegicus	79.78	0.00e+00	1267.00
IUUC-Sha-106781	Sarcophilus harrisii	81.14	0.00e+00	1494.00
IUUC-Ssc-116307	Sus scrofa	78.26	0.00e+00	1341.00
IUUC-Tgu-116530	Taeniopygia guttata	79.95	0.00e+00	1254.00
IUUC-Tru-118287	Takifugu rubripes	91.21	0.00e+00	1087.00
IUUC-Tni-120801	Tetraodon nigroviridis	91.62	0.00e+00	1095.00
IUUC-Tbe-127793	Tupaia belangeri	75.76	0.00e+00	1082.00
IUUC-Ttr-128275	Tursiops truncatus	85.53	0.00e+00	1184.00
IUUC-Xtr-132866	Xenopus tropicalis	85.99	0.00e+00	1132.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence