iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027994

Ensembl Protein ID

ENSDARP00000137571.1

UniProt Accession

Q6DHL4; SUMO2_DANRE

Genbank Protein ID

AAH75956.1

Protein Name

Small ubiquitin-related modifier 2

Genbank Nucleotide ID

BC075956

Gene Name

sumo2b; sumo2; zgc:92241

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000102741.1	ENSDART00000157771.1	ENSDARP00000137571.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/SUMO	1.10e-32	113.5	14	93

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/SUMO

   S: 5    fkapvslkvagqdGsevlfklklsaqlkklmeavYvkrinldensvrfvfngqkireqetpeelevededkiellcqksGG 85
           +  +++lkvagqdGs v+fk+k++++l+klm+a Y++r++l ++++rf+f+gq+i+e++tp++le+eded+i++++q++GG
   Q: 14   NNDHINLKVAGQDGSVVQFKIKRHTPLSKLMKA-YCERQGLTMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG 93
           789******************************.**********************************************9 PP

Organism

Danio rerio

Functional Description
(View)

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 and linkage to the E2 enzyme ube2i, and can be promoted by an E3 ligase such as pias1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

Protein Sequence
(Fasta)

MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLTMRQIRF 60
RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGHRI 96

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGTGTGG CGGCGTAGAG AAGCGCAAAT ACAATAACCA TGGCCGACGA GAAACCCAAG 60
GTGAGTGGCG ATTAAAAAAA GGAAGGATTA TTTATTTTTA TTCACAGCTC GAGTTGTGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR022617--Rad60/SUMO-like_dom
IPR033950--Sumo
IPR027218--SUMO_2/3
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF11976--Rad60-SLD

SMART

SM00213--UBQ

Gene Ontology

GO:0005634--C:nucleus
GO:0031386--F:protein tag
GO:0043009--P:chordate embryonic development
GO:0060216--P:definitive hemopoiesis
GO:0016925--P:protein sumoylation

KEGG

dre:445027

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001918	Ailuropoda melanoleuca	98.92	1.00e-51	193.00
IUUC-Apl-003372	Anas platyrhynchos	97.70	2.00e-47	179.00
IUUC-Aca-005284	Anolis carolinensis	98.92	1.00e-51	193.00
IUUC-Aly-005765	Arabidopsis lyrata	52.75	4.00e-21	92.80
IUUC-Ath-007391	Arabidopsis thaliana	52.75	3.00e-21	92.80
IUUC-Afu-008969	Aspergillus fumigatus	46.81	1.00e-17	80.90
IUUC-Ame-011427	Astyanax mexicanus	98.92	2.00e-51	193.00
IUUC-Bgr-012250	Blumeria graminis	45.88	1.00e-16	78.20
IUUC-Bol-015977	Brassica oleracea	52.75	3.00e-21	92.80
IUUC-Bra-017542	Brassica rapa	52.75	3.00e-21	92.80
IUUC-Cfa-020733	Canis familiaris	98.88	5.00e-49	186.00
IUUC-Cpo-021498	Cavia porcellus	98.92	1.00e-51	193.00
IUUC-Csa-023133	Chlorocebus sabaeus	98.92	1.00e-51	193.00
IUUC-Cin-025314	Ciona intestinalis	74.49	2.00e-38	150.00
IUUC-Csv-026212	Ciona savignyi	74.49	5.00e-39	151.00
IUUC-Cme-027181	Cyanidioschyzon merolae	55.32	2.00e-23	100.00
IUUC-Dno-029390	Dasypus novemcinctus	98.92	4.00e-52	196.00
IUUC-Dor-030760	Dipodomys ordii	31.17	8.00e-06	44.70
IUUC-Ete-032934	Echinops telfairi	81.72	6.00e-41	158.00
IUUC-Eca-033260	Equus caballus	98.92	1.00e-51	193.00
IUUC-Fca-036393	Felis catus	92.47	7.00e-48	181.00
IUUC-Fal-037226	Ficedula albicollis	97.73	4.00e-48	182.00
IUUC-Fso-038430	Fusarium solani	50.60	2.00e-19	87.00
IUUC-Gmo-038535	Gadus morhua	93.55	3.00e-49	185.00
IUUC-Ggr-040015	Gaeumannomyces graminis	57.14	1.00e-20	91.30
IUUC-Gga-040145	Gallus gallus	98.92	1.00e-51	193.00
IUUC-Gac-041723	Gasterosteus aculeatus	92.47	8.00e-49	184.00
IUUC-Ggo-045467	Gorilla gorilla	98.92	1.00e-51	193.00
IUUC-Hsa-046419	Homo sapiens	98.92	1.00e-51	193.00
IUUC-Hvu-047514	Hordeum vulgare	58.44	2.00e-20	90.50
IUUC-Itr-048667	Ictidomys tridecemlineatus	94.51	5.00e-48	181.00
IUUC-Lch-050572	Latimeria chalumnae	89.47	9.00e-45	171.00
IUUC-Loc-052560	Lepisosteus oculatus	100.00	7.00e-52	194.00
IUUC-Laf-054343	Loxodonta africana	98.92	1.00e-51	193.00
IUUC-Mcc-054832	Macaca mulatta	98.90	3.00e-50	190.00
IUUC-Mpo-057351	Magnaporthe poae	57.14	1.00e-20	90.90
IUUC-Mga-059768	Meleagris gallopavo	97.70	2.00e-47	179.00
IUUC-Mmr-061593	Microcebus murinus	98.90	2.00e-50	190.00
IUUC-Mdo-062678	Monodelphis domestica	98.92	1.00e-51	193.00
IUUC-Mmu-063990	Mus musculus	98.92	1.00e-51	193.00
IUUC-Mpu-065909	Mustela putorius furo	97.73	3.00e-48	182.00
IUUC-Mlu-067634	Myotis lucifugus	92.47	1.00e-47	180.00
IUUC-Ncr-068663	Neurospora crassa	52.56	4.00e-19	85.90
IUUC-Nle-069631	Nomascus leucogenys	95.70	7.00e-50	187.00
IUUC-Ont-071512	Oreochromis niloticus	94.68	8.00e-50	187.00
IUUC-Ocu-074239	Oryctolagus cuniculus	97.85	3.00e-51	192.00
IUUC-Ola-086710	Oryzias latipes	96.77	3.00e-50	189.00
IUUC-Oar-089624	Ovis aries	93.55	9.00e-49	184.00
IUUC-Ptr-091082	Pan troglodytes	98.92	1.00e-51	193.00
IUUC-Pan-091791	Papio anubis	98.90	3.00e-50	190.00
IUUC-Psi-094000	Pelodiscus sinensis	98.92	1.00e-51	193.00
IUUC-Pfo-097304	Poecilia formosa	93.75	4.00e-51	191.00
IUUC-Pab-098572	Pongo abelii	98.92	1.00e-51	193.00
IUUC-Ppe-101648	Prunus persica	52.75	5.00e-21	92.00
IUUC-Rno-105391	Rattus norvegicus	97.83	2.00e-50	189.00
IUUC-Sar-113337	Sorex araneus	82.80	4.00e-42	162.00
IUUC-Sbi-114801	Sorghum bicolor	53.85	3.00e-21	92.80
IUUC-Ssc-115915	Sus scrofa	98.92	1.00e-51	193.00
IUUC-Tgu-116815	Taeniopygia guttata	97.73	3.00e-48	182.00
IUUC-Tre-121926	Trichoderma reesei	46.81	5.00e-21	92.00
IUUC-Tvi-122514	Trichoderma virens	50.60	1.00e-19	87.40
IUUC-Tae-125013	Triticum aestivum	52.13	2.00e-22	97.40
IUUC-Tur-126333	Triticum urartu	40.68	4.00e-17	80.90
IUUC-Tbe-127363	Tupaia belangeri	92.47	4.00e-47	178.00
IUUC-Vvi-131092	Vitis vinifera	52.75	5.00e-21	92.40
IUUC-Xtr-132691	Xenopus tropicalis	96.77	1.00e-50	190.00
IUUC-Xma-133892	Xiphophorus maculatus	93.75	2.00e-51	193.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence