iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034137

Ensembl Protein ID

ENSECAP00000017584.1

UniProt Accession

F7CFL4; F7CFL4_HORSE

Protein Name

Uncharacterized protein

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000019366.1	ENSECAT00000021357.1	ENSECAP00000017584.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.10e-15	54.5	84	138

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL++ kGdv++v     +++gW++g  + +g+ G fP+n+v++++
   Q: 84   VVRAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--THNGRTGWFPSNYVREIK 138
           78999*********************7..999*******..8**************996 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

QTFDANDLYQ GQNFNKVLSS LVTLNKVTAD IGLGSDSVCA RPTSHRIKSF DSLGSQPSHS 60
RTSKLFQGQY RSLDMTDNSN NQLVVRAKFN FQQTNEDELS FSKGDVIHVT RVEEGGWWEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGACGTTTG ATGCAAATGA CTTGTACCAG GGGCAGAATT TTAACAAGGT CCTCAGTTCC 60
TTAGTGACTC TAAATAAAGT AACAGCAGGT AAGACTTTTT TTTAATTGAA CGTGACGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	96.66	0.00e+00	1204.00
IUUC-Aca-004591	Anolis carolinensis	92.55	0.00e+00	1253.00
IUUC-Ame-010759	Astyanax mexicanus	76.25	0.00e+00	1149.00
IUUC-Bta-013328	Bos taurus	95.25	0.00e+00	1394.00
IUUC-Cja-018742	Callithrix jacchus	96.08	0.00e+00	1201.00
IUUC-Cfa-020756	Canis familiaris	96.50	0.00e+00	1165.00
IUUC-Cpo-021284	Cavia porcellus	95.12	0.00e+00	1327.00
IUUC-Csa-023162	Chlorocebus sabaeus	96.41	0.00e+00	1382.00
IUUC-Cho-024736	Choloepus hoffmanni	75.06	4.00e-177	614.00
IUUC-Cin-025535	Ciona intestinalis	40.43	7.00e-95	340.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	44.29	9.00e-12	66.20
IUUC-Cne-026866	Cryptococcus neoformans	49.21	8.00e-13	70.10
IUUC-Dre-028646	Danio rerio	75.61	0.00e+00	1136.00
IUUC-Dno-029461	Dasypus novemcinctus	96.92	0.00e+00	1384.00
IUUC-Dor-030623	Dipodomys ordii	85.44	0.00e+00	1027.00
IUUC-Dse-031165	Dothistroma septosporum	37.66	2.00e-11	65.10
IUUC-Dme-032219	Drosophila melanogaster	44.94	7.00e-103	369.00
IUUC-Ete-032236	Echinops telfairi	81.47	0.00e+00	815.00
IUUC-Fca-035742	Felis catus	96.34	0.00e+00	1136.00
IUUC-Fal-037205	Ficedula albicollis	94.75	0.00e+00	1205.00
IUUC-Fso-038433	Fusarium solani	43.06	2.00e-12	68.20
IUUC-Gmo-039475	Gadus morhua	68.77	0.00e+00	948.00
IUUC-Gga-040539	Gallus gallus	78.72	0.00e+00	986.00
IUUC-Gac-042615	Gasterosteus aculeatus	64.78	0.00e+00	859.00
IUUC-Ggo-044470	Gorilla gorilla	91.30	0.00e+00	1300.00
IUUC-Hsa-046398	Homo sapiens	96.22	0.00e+00	1202.00
IUUC-Kpa-049278	Komagataella pastoris	26.78	2.00e-17	84.30
IUUC-Loc-052146	Lepisosteus oculatus	86.15	0.00e+00	1249.00
IUUC-Laf-053891	Loxodonta africana	96.27	0.00e+00	1428.00
IUUC-Mcc-055483	Macaca mulatta	96.07	0.00e+00	1201.00
IUUC-Mpo-057322	Magnaporthe poae	33.85	8.00e-12	66.60
IUUC-Mla-059044	Melampsora laricipopulina	27.43	3.00e-20	94.40
IUUC-Mga-059410	Meleagris gallopavo	94.22	0.00e+00	1340.00
IUUC-Mmr-060758	Microcebus murinus	96.95	0.00e+00	1157.00
IUUC-Mdo-061900	Monodelphis domestica	80.74	0.00e+00	1143.00
IUUC-Mmu-063849	Mus musculus	94.33	0.00e+00	1142.00
IUUC-Mpu-065876	Mustela putorius furo	95.87	0.00e+00	1154.00
IUUC-Mlu-067970	Myotis lucifugus	97.56	0.00e+00	1391.00
IUUC-Nle-069685	Nomascus leucogenys	78.16	0.00e+00	1052.00
IUUC-Opr-071132	Ochotona princeps	63.61	0.00e+00	704.00
IUUC-Ont-071815	Oreochromis niloticus	75.74	0.00e+00	1130.00
IUUC-Oan-073057	Ornithorhynchus anatinus	94.33	0.00e+00	1224.00
IUUC-Ola-086663	Oryzias latipes	73.94	0.00e+00	1045.00
IUUC-Oga-088103	Otolemur garnettii	95.76	0.00e+00	1318.00
IUUC-Ptr-091162	Pan troglodytes	96.08	0.00e+00	1201.00
IUUC-Pan-092093	Papio anubis	85.66	0.00e+00	1232.00
IUUC-Pma-094261	Petromyzon marinus	66.56	5.00e-126	443.00
IUUC-Pfo-096932	Poecilia formosa	63.87	0.00e+00	935.00
IUUC-Pab-097641	Pongo abelii	95.87	0.00e+00	1149.00
IUUC-Pva-102819	Pteropus vampyrus	93.60	0.00e+00	1145.00
IUUC-Pgr-103400	Puccinia graminis	27.43	2.00e-20	95.10
IUUC-Rno-106099	Rattus norvegicus	94.61	0.00e+00	1313.00
IUUC-Sha-106845	Sarcophilus harrisii	80.49	0.00e+00	1141.00
IUUC-Ssc-116036	Sus scrofa	94.75	0.00e+00	1131.00
IUUC-Tgu-117498	Taeniopygia guttata	94.61	0.00e+00	1348.00
IUUC-Tru-118278	Takifugu rubripes	73.33	0.00e+00	1053.00
IUUC-Tsy-118990	Tarsius syrichta	94.70	0.00e+00	976.00
IUUC-Tni-120852	Tetraodon nigroviridis	74.29	0.00e+00	885.00
IUUC-Ttr-128922	Tursiops truncatus	92.57	0.00e+00	1125.00
IUUC-Xtr-132012	Xenopus tropicalis	86.03	0.00e+00	1136.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence