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Tag Content
UUCD2 ID IUUC-Xtr-132134
UUCD1 version UUC-XeT-00007
Ensembl Protein ID ENSXETP00000036490.2
UniProt Accession A4IHK8; DCNL3_XENTR
Genbank Protein ID AAI35573.1
Protein Name DCN1-like protein 3; DCUN1 domain-containing protein 3; Defective in cullin neddylation protein 1-like protein 3
Genbank Nucleotide ID BC135572
Gene Name dcun1d3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000016729.2 ENSXETT00000036490.2 ENSXETP00000036490.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/DCUN1 2.40e-80 269.2 86 277
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/DCUN1
   S: 2    skkkleelferYkdpqedligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktleselkd 90
           s++++eelf rYkd++ed+i++eg+e+fc+dl vdp++++vLvlawk++aat+c+f+r+ef++g++a+++d ie++++++++l +e+k+
   Q: 86   SVQRIEELFWRYKDEREDAILEEGMERFCNDLYVDPTEFRVLVLAWKFQAATMCKFTRREFFEGCKAINADGIEGICARFPSLLNEAKQ 174
           679************************************************************************************** PP
   S: 91   eqkfkdiYrfafnfakd..kgqksldldtaialwkLllaerefklldawlkfLeee..kkksiskDtWnllLefskviakdlsnYdeeg 175
           e+kfkd+Yrf+f+f++d  +gq+sl++++aialwkL+++++++ +ld+wl+fL+e+  ++k+is+DtWn++L+f++vi +dlsnY+e++
   Q: 175  EDKFKDLYRFTFQFGLDseEGQRSLHREIAIALWKLVFTQNKPLILDQWLDFLTENpsGIKGISRDTWNMFLNFTQVIGPDLSNYSEDE 263
           ***************998899**********************************9889****************************** PP
   S: 176  aWPvliDefveylk 189
           aWP+l+D+fve+++
   Q: 264  AWPSLFDTFVEWEM 277
           ************85 PP
   
Organism Xenopus tropicalis
Functional Description
(View)

Functional Description


     Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.
 Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane.
Protein Sequence
(Fasta)
MGQCVTKCKN PSSTLGSKNG ERESSKPHKR SSSHKDEHLS ICGKASREIL VNGTKKGDVS 60
LEASQPLAAG GDTKKKEQGT GAELSSVQRI EELFWRYKDE REDAILEEGM ERFCNDLYVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132134|E3,DCUN1|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGTGACGTC GGTAGAAGTG CGCCGGGCGC AGCGGGCACG TCACGGCTGG AGGAAAGGAA 60
GGAGGGGGAG CTGGAAGGTG CGGACGTCGC AGGCTCACAA GTGATTGGGG CGCTGCCGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132134|E3,DCUN1|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-1185--Reference proteome
Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
PROSITE

PS51229--DCUN1
Pfam

PF03556--Cullin_binding
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation
GO:0009314--P:response to radiation
KEGG xtr:100124860
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001689 Ailuropoda melanoleuca 80.14 8.00e-129 452.00
IUUC-Apl-003497 Anas platyrhynchos 84.26 8.00e-140 489.00
IUUC-Aca-004961 Anolis carolinensis 81.42 1.00e-138 484.00
IUUC-Aor-009902 Aspergillus oryzae 34.40 3.00e-11 60.10
IUUC-Ame-011413 Astyanax mexicanus 65.09 9.00e-103 366.00
IUUC-Bta-013338 Bos taurus 81.59 4.00e-131 460.00
IUUC-Cja-019458 Callithrix jacchus 80.14 3.00e-129 454.00
IUUC-Cfa-020160 Canis familiaris 80.51 2.00e-129 454.00
IUUC-Cpo-021835 Cavia porcellus 75.74 6.00e-124 436.00
IUUC-Csa-023328 Chlorocebus sabaeus 80.14 2.00e-129 454.00
IUUC-Cho-024888 Choloepus hoffmanni 80.29 1.00e-129 455.00
IUUC-Cin-025134 Ciona intestinalis 54.00 9.00e-62 230.00
IUUC-Csv-025904 Ciona savignyi 51.22 8.00e-33 131.00
IUUC-Dre-027780 Danio rerio 62.32 5.00e-96 343.00
IUUC-Dno-028866 Dasypus novemcinctus 79.78 4.00e-127 447.00
IUUC-Dor-030387 Dipodomys ordii 80.36 2.00e-128 451.00
IUUC-Dme-032081 Drosophila melanogaster 48.98 7.00e-47 180.00
IUUC-Eca-033857 Equus caballus 80.51 1.00e-129 455.00
IUUC-Eeu-034825 Erinaceus europaeus 70.82 9.00e-115 405.00
IUUC-Fca-036130 Felis catus 80.14 2.00e-128 451.00
IUUC-Fal-037296 Ficedula albicollis 82.30 1.00e-134 472.00
IUUC-Gmo-039626 Gadus morhua 65.25 2.00e-99 355.00
IUUC-Ggr-039959 Gaeumannomyces graminis 26.89 7.00e-15 75.50
IUUC-Gga-040741 Gallus gallus 82.24 4.00e-137 480.00
IUUC-Gac-042271 Gasterosteus aculeatus 65.59 6.00e-94 337.00
IUUC-Ggo-044727 Gorilla gorilla 80.14 2.00e-129 454.00
IUUC-Hsa-046288 Homo sapiens 80.51 9.00e-130 456.00
IUUC-Itr-049054 Ictidomys tridecemlineatus 77.38 7.00e-135 473.00
IUUC-Lch-050289 Latimeria chalumnae 77.23 3.00e-130 457.00
IUUC-Loc-052455 Lepisosteus oculatus 69.06 2.00e-106 378.00
IUUC-Laf-054369 Loxodonta africana 79.06 7.00e-124 436.00
IUUC-Mcc-055413 Macaca mulatta 65.34 4.00e-94 337.00
IUUC-Meu-056535 Macropus eugenii 77.38 8.00e-133 466.00
IUUC-Mga-059290 Meleagris gallopavo 83.28 5.00e-138 483.00
IUUC-Mmr-060689 Microcebus murinus 80.51 1.00e-129 455.00
IUUC-Mdo-062128 Monodelphis domestica 76.39 5.00e-126 443.00
IUUC-Mmu-064396 Mus musculus 77.70 9.00e-136 475.00
IUUC-Mpu-065926 Mustela putorius furo 80.14 8.00e-129 452.00
IUUC-Mlu-067044 Myotis lucifugus 78.31 5.00e-133 466.00
IUUC-Nle-069346 Nomascus leucogenys 80.14 2.00e-129 454.00
IUUC-Opr-070682 Ochotona princeps 78.70 5.00e-123 433.00
IUUC-Ont-071772 Oreochromis niloticus 70.71 1.00e-104 372.00
IUUC-Oan-072765 Ornithorhynchus anatinus 77.70 2.00e-127 447.00
IUUC-Ocu-074272 Oryctolagus cuniculus 90.67 4.00e-104 370.00
IUUC-Ola-087561 Oryzias latipes 67.77 7.00e-106 376.00
IUUC-Oga-088440 Otolemur garnettii 65.45 1.00e-98 352.00
IUUC-Oar-089403 Ovis aries 81.59 3.00e-131 460.00
IUUC-Ptr-091384 Pan troglodytes 80.14 2.00e-129 454.00
IUUC-Pan-092650 Papio anubis 80.14 2.00e-129 454.00
IUUC-Psi-093806 Pelodiscus sinensis 81.64 1.00e-132 465.00
IUUC-Pma-094196 Petromyzon marinus 52.04 4.00e-84 304.00
IUUC-Pfo-096584 Poecilia formosa 68.68 4.00e-103 367.00
IUUC-Pab-098605 Pongo abelii 80.14 2.00e-129 454.00
IUUC-Pca-100933 Procavia capensis 62.18 2.00e-86 311.00
IUUC-Pva-102172 Pteropus vampyrus 80.00 3.00e-130 457.00
IUUC-Rno-105406 Rattus norvegicus 78.03 3.00e-136 477.00
IUUC-Sha-106531 Sarcophilus harrisii 77.05 4.00e-133 467.00
IUUC-Sar-113051 Sorex araneus 64.60 2.00e-95 341.00
IUUC-Ssc-115555 Sus scrofa 80.51 1.00e-129 455.00
IUUC-Tgu-117178 Taeniopygia guttata 83.61 8.00e-138 482.00
IUUC-Tru-117876 Takifugu rubripes 68.75 3.00e-105 374.00
IUUC-Tsy-118790 Tarsius syrichta 78.57 1.00e-109 389.00
IUUC-Tni-119673 Tetraodon nigroviridis 66.89 7.00e-105 373.00
IUUC-Tbe-127429 Tupaia belangeri 80.14 8.00e-130 456.00
IUUC-Ttr-128467 Tursiops truncatus 80.51 1.00e-129 455.00
IUUC-Vpa-130376 Vicugna pacos 55.07 1.00e-73 269.00
Created Date 25-Jun-2017

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