iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-116772

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

ABQF01043537

Gene Name

NAE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000009718.1	ENSTGUT00000010144.1	ENSTGUP00000010037.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.40e-114	383.4	5	518

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvg.ksKAevaaealkelnpdv 88
           YDRQ+rlwG+++qe+l+sa+v++++a+++G+E+lKnLvl G+gs+t+vD+++v+ ++++++ ++ +++vg  ++A++a e l+eln dv
   Q: 5    YDRQLRLWGDHGQEALESAHVCVINATATGTEILKNLVLPGIGSFTIVDGNQVSGEDVGNNHFVFRSSVGlENRAQSATELLQELNGDV 93
           *********************************************************************7479**************** PP
   S: 89   nveaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPf 173
           ++ ++ees+++l ++++ Ff++f++Vv+++ ++++ ++++++++n ++pl+ ++t+Gl+G++rv+ik++t+ +s++d   +++++++Pf
   Q: 94   SGNFVEESPEKLLDNDPsFFNRFNLVVATQLPESTLLRLAEVLWNSNIPLLVCRTYGLVGYMRVVIKEHTVVESHPDnmlEDLRLDKPF 182
           ***************************************************************************************** PP
   S: 174  ctlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafak 247
           ++l+e+++         +++++++w+v+++k+l ++ +e++++ +++++eke++k+++++++ +      edeenfeeai+++++a+++
   Q: 183  PELIEHVQdydlermdkKDHSHTPWIVIVAKYLTKWFSEKSEQLPKNYKEKEAFKELIRQGILKndngtpEDEENFEEAIKNVNTALNR 271
           ******99999999999***********************************************9************************ PP
   S: 248  ttins.ikqllksfecdivtkskspfwv............................................................. 274
           t+i+  i++l++++ c ++t+++s+fw+                                                             
   Q: 272  TEIPRgIEELFNDDCCLKLTEQSSSFWIlvralkefvanegqgslpvrgtipdmmadsnkfiklqnvyrekakkdtaavgshaakllqs 360
           ***************************************************************************************** PP
   S: 275  ..............sfcsnaealqvp................ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekd 328
                          fc na+ l v                 + +++ + +     p     lyl+lra++rf k++gr+pg+ +++++
   Q: 361  lgkapesvserelkLFCDNAAFLHVVrcrslaeehspnscsrDAIISHMDN-----PdseivLYLMLRAVNRFYKQHGRYPGVYNYQVE 444
           **************8888888888444444444444433333555555555.....455556*************************** PP
   S: 329  dds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           dd+  + +++t ++    +++g++  ++dd+++e++++++++ + ++a+ gG+aaqEviKv++g+f+ ++n+f++ ++
   Q: 445  DDIgkLKSCLTGFL----QEHGLSVAVKDDYVHEFCRYGAAEPHAVAAFMGGAAAQEVIKVITGQFVIFNNTFIYSGM 518
           ***999********....********************************************************9876 PP

Organism

Taeniopygia guttata

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

KEQRYDRQLR LWGDHGQEAL ESAHVCVINA TATGTEILKN LVLPGIGSFT IVDGNQVSGE 60
DVGNNHFVFR SSVGLENRAQ SATELLQELN GDVSGNFVEE SPEKLLDNDP SFFNRFNLVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGGAGCAGC GCTACGATCG CCAGCTCAGG TACCTCGGGC GGGCACGGAC CGGCACGGAC 60
GAACACGGTC CGGCACCGCC CGGCACCGCC CGGCACCGCC CGACCGAGCG CAGAGCGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0033314--P:mitotic DNA replication checkpoint
GO:0051402--P:neuron apoptotic process
GO:0045116--P:protein neddylation
GO:0043523--P:regulation of neuron apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	42.13	3.00e-120	424.00
IUUC-Aml-002333	Ailuropoda melanoleuca	80.11	0.00e+00	907.00
IUUC-Atr-002644	Amborella trichopoda	40.61	7.00e-111	393.00
IUUC-Apl-003446	Anas platyrhynchos	87.69	0.00e+00	938.00
IUUC-Aca-004450	Anolis carolinensis	77.04	0.00e+00	872.00
IUUC-Aly-006187	Arabidopsis lyrata	41.02	1.00e-122	432.00
IUUC-Ath-007600	Arabidopsis thaliana	40.68	2.00e-121	429.00
IUUC-Ago-007900	Ashbya gossypii	26.17	7.00e-37	147.00
IUUC-Acl-008333	Aspergillus clavatus	33.63	3.00e-75	275.00
IUUC-Afl-008529	Aspergillus flavus	35.03	6.00e-79	288.00
IUUC-Afu-009071	Aspergillus fumigatus	32.25	6.00e-73	268.00
IUUC-Ani-009443	Aspergillus nidulans	32.60	4.00e-71	261.00
IUUC-Ang-009669	Aspergillus niger	31.83	5.00e-75	274.00
IUUC-Aor-009914	Aspergillus oryzae	34.35	1.00e-75	276.00
IUUC-Ate-010450	Aspergillus terreus	33.15	8.00e-77	280.00
IUUC-Ame-011183	Astyanax mexicanus	71.16	0.00e+00	812.00
IUUC-Bgr-012111	Blumeria graminis	31.64	3.00e-57	215.00
IUUC-Bta-012583	Bos taurus	80.83	0.00e+00	912.00
IUUC-Bci-013892	Botrytis cinerea	31.68	2.00e-59	223.00
IUUC-Bdi-014592	Brachypodium distachyon	42.50	3.00e-121	427.00
IUUC-Bol-016399	Brassica oleracea	40.98	1.00e-121	429.00
IUUC-Bra-017506	Brassica rapa	40.30	2.00e-118	419.00
IUUC-Cel-018456	Caenorhabditis elegans	34.32	1.00e-88	319.00
IUUC-Cja-020007	Callithrix jacchus	80.00	0.00e+00	905.00
IUUC-Cfa-020324	Canis familiaris	81.40	0.00e+00	919.00
IUUC-Cpo-022248	Cavia porcellus	55.64	2.00e-153	535.00
IUUC-Csa-023149	Chlorocebus sabaeus	78.31	0.00e+00	775.00
IUUC-Cho-024537	Choloepus hoffmanni	69.41	0.00e+00	662.00
IUUC-Cin-025763	Ciona intestinalis	51.22	2.00e-155	541.00
IUUC-Csv-026113	Ciona savignyi	48.43	4.00e-144	504.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	30.72	5.00e-61	228.00
IUUC-Cne-026884	Cryptococcus neoformans	30.57	8.00e-69	254.00
IUUC-Cme-027210	Cyanidioschyzon merolae	27.23	3.00e-18	86.30
IUUC-Dre-028140	Danio rerio	72.11	0.00e+00	828.00
IUUC-Dno-030033	Dasypus novemcinctus	80.00	0.00e+00	793.00
IUUC-Dor-030513	Dipodomys ordii	55.27	2.00e-95	342.00
IUUC-Dse-031536	Dothistroma septosporum	32.92	3.00e-79	288.00
IUUC-Dme-031683	Drosophila melanogaster	44.53	1.00e-124	439.00
IUUC-Ete-032420	Echinops telfairi	71.57	0.00e+00	772.00
IUUC-Eca-033992	Equus caballus	80.63	0.00e+00	769.00
IUUC-Eeu-034713	Erinaceus europaeus	66.14	4.00e-98	351.00
IUUC-Fca-036548	Felis catus	79.70	0.00e+00	897.00
IUUC-Fal-037600	Ficedula albicollis	93.50	0.00e+00	997.00
IUUC-Fox-038037	Fusarium oxysporum	32.23	1.00e-68	253.00
IUUC-Fso-038387	Fusarium solani	32.91	6.00e-72	264.00
IUUC-Gmo-038562	Gadus morhua	69.57	0.00e+00	803.00
IUUC-Ggr-040005	Gaeumannomyces graminis	32.54	3.00e-67	249.00
IUUC-Gga-041129	Gallus gallus	87.29	0.00e+00	950.00
IUUC-Gac-042558	Gasterosteus aculeatus	70.32	0.00e+00	807.00
IUUC-Gma-043610	Glycine max	41.24	4.00e-117	414.00
IUUC-Ggo-045611	Gorilla gorilla	80.00	0.00e+00	904.00
IUUC-Hsa-046563	Homo sapiens	80.27	0.00e+00	907.00
IUUC-Hvu-047790	Hordeum vulgare	38.93	4.00e-75	274.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	80.27	0.00e+00	903.00
IUUC-Kpa-049309	Komagataella pastoris	33.27	2.00e-76	279.00
IUUC-Lch-050038	Latimeria chalumnae	74.24	0.00e+00	831.00
IUUC-Lpe-051535	Leersia perrieri	41.00	6.00e-107	380.00
IUUC-Loc-051917	Lepisosteus oculatus	68.76	0.00e+00	770.00
IUUC-Lma-053112	Leptosphaeria maculans	34.95	4.00e-81	295.00
IUUC-Laf-053690	Loxodonta africana	80.83	0.00e+00	914.00
IUUC-Mcc-055117	Macaca mulatta	79.43	0.00e+00	900.00
IUUC-Meu-056761	Macropus eugenii	67.92	0.00e+00	728.00
IUUC-Mor-057230	Magnaporthe oryzae	32.91	3.00e-71	261.00
IUUC-Mpo-057514	Magnaporthe poae	32.31	4.00e-65	241.00
IUUC-Mtr-058551	Medicago truncatula	40.99	4.00e-115	407.00
IUUC-Mla-059183	Melampsora laricipopulina	38.04	4.00e-100	358.00
IUUC-Mga-060144	Meleagris gallopavo	86.76	0.00e+00	931.00
IUUC-Mvi-060221	Microbotryum violaceum	34.81	6.00e-78	284.00
IUUC-Mmr-061325	Microcebus murinus	80.34	0.00e+00	912.00
IUUC-Mdo-062532	Monodelphis domestica	81.02	0.00e+00	915.00
IUUC-Mmu-063956	Mus musculus	80.08	0.00e+00	906.00
IUUC-Mac-064521	Musa acuminata	41.26	3.00e-119	421.00
IUUC-Mpu-066716	Mustela putorius furo	79.19	0.00e+00	845.00
IUUC-Mlu-067459	Myotis lucifugus	80.11	0.00e+00	904.00
IUUC-Nfi-068245	Neosartorya fischeri	32.43	9.00e-74	270.00
IUUC-Ncr-068910	Neurospora crassa	31.83	6.00e-69	254.00
IUUC-Nle-070034	Nomascus leucogenys	78.52	0.00e+00	884.00
IUUC-Opr-070552	Ochotona princeps	72.87	0.00e+00	736.00
IUUC-Ont-071426	Oreochromis niloticus	70.59	0.00e+00	815.00
IUUC-Oan-073389	Ornithorhynchus anatinus	76.58	0.00e+00	716.00
IUUC-Ocu-074911	Oryctolagus cuniculus	80.83	0.00e+00	911.00
IUUC-Oba-075437	Oryza barthii	41.94	1.00e-111	396.00
IUUC-Obr-076684	Oryza brachyantha	42.31	1.00e-107	383.00
IUUC-Ogl-077170	Oryza glaberrima	41.94	1.00e-111	396.00
IUUC-Ogu-078844	Oryza glumaepatula	42.43	2.00e-105	375.00
IUUC-Oin-079105	Oryza indica	41.94	5.00e-111	394.00
IUUC-Olo-080943	Oryza longistaminata	40.80	1.00e-101	363.00
IUUC-Oni-082891	Oryza nivara	40.42	7.00e-107	380.00
IUUC-Opu-083457	Oryza punctata	41.94	4.00e-111	394.00
IUUC-Oru-084960	Oryza rufipogon	40.80	1.00e-101	363.00
IUUC-Osa-085358	Oryza sativa	42.10	2.00e-111	395.00
IUUC-Ola-086420	Oryzias latipes	71.05	2.00e-167	581.00
IUUC-Olu-087625	Ostreococcus lucimarinus	31.56	5.00e-62	231.00
IUUC-Oga-088810	Otolemur garnettii	80.08	0.00e+00	909.00
IUUC-Oar-089196	Ovis aries	80.19	0.00e+00	904.00
IUUC-Ptr-090617	Pan troglodytes	80.46	0.00e+00	909.00
IUUC-Pan-092761	Papio anubis	80.65	0.00e+00	910.00
IUUC-Psi-093191	Pelodiscus sinensis	82.82	0.00e+00	920.00
IUUC-Pma-094380	Petromyzon marinus	62.75	0.00e+00	660.00
IUUC-Pno-095084	Phaeosphaeria nodorum	30.76	2.00e-64	241.00
IUUC-Ppa-095875	Physcomitrella patens	42.37	3.00e-121	428.00
IUUC-Pfo-096467	Poecilia formosa	70.00	0.00e+00	797.00
IUUC-Pab-098255	Pongo abelii	78.49	0.00e+00	737.00
IUUC-Pop-099871	Populus trichocarpa	41.29	7.00e-123	433.00
IUUC-Pca-100807	Procavia capensis	68.05	8.00e-101	360.00
IUUC-Ppe-101280	Prunus persica	41.05	5.00e-119	421.00
IUUC-Pva-102333	Pteropus vampyrus	77.55	0.00e+00	858.00
IUUC-Pgr-103401	Puccinia graminis	30.98	3.00e-77	282.00
IUUC-Ptt-103889	Puccinia triticina	28.85	3.00e-59	222.00
IUUC-Pte-104355	Pyrenophora teres	33.87	1.00e-81	296.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	34.22	1.00e-81	296.00
IUUC-Rno-105810	Rattus norvegicus	80.46	0.00e+00	904.00
IUUC-Sce-106397	Saccharomyces cerevisiae	27.97	1.00e-40	160.00
IUUC-Sha-106770	Sarcophilus harrisii	82.12	8.00e-137	478.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	31.95	2.00e-70	259.00
IUUC-Spo-108276	Schizosaccharomyces pombe	34.34	3.00e-82	298.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	31.01	1.00e-61	230.00
IUUC-Smo-109296	Selaginella moellendorffii	41.59	5.00e-117	414.00
IUUC-Sit-110157	Setaria italica	43.83	2.00e-128	451.00
IUUC-Sly-111105	Solanum lycopersicum	40.44	1.00e-119	422.00
IUUC-Stu-112469	Solanum tuberosum	41.33	1.00e-122	433.00
IUUC-Sar-113083	Sorex araneus	62.48	0.00e+00	656.00
IUUC-Sbi-113813	Sorghum bicolor	43.26	2.00e-125	442.00
IUUC-Sre-115058	Sporisorium reilianum	38.89	4.00e-84	305.00
IUUC-Tru-118686	Takifugu rubripes	70.21	0.00e+00	811.00
IUUC-Tsy-119111	Tarsius syrichta	77.17	1.00e-124	439.00
IUUC-Tni-120231	Tetraodon nigroviridis	65.47	0.00e+00	733.00
IUUC-Tca-121491	Theobroma cacao	40.41	3.00e-114	405.00
IUUC-Tre-122103	Trichoderma reesei	35.78	1.00e-75	276.00
IUUC-Tvi-122672	Trichoderma virens	34.85	4.00e-68	251.00
IUUC-Tae-125679	Triticum aestivum	42.72	2.00e-122	432.00
IUUC-Tur-126487	Triticum urartu	41.56	5.00e-116	410.00
IUUC-Tme-127097	Tuber melanosporum	36.00	2.00e-88	319.00
IUUC-Ttr-128465	Tursiops truncatus	75.66	0.00e+00	841.00
IUUC-Uma-129645	Ustilago maydis	33.94	1.00e-89	323.00
IUUC-Vda-129989	Verticillium dahliae	30.31	2.00e-52	199.00
IUUC-Vpa-130529	Vicugna pacos	77.17	0.00e+00	865.00
IUUC-Vvi-131059	Vitis vinifera	40.75	6.00e-118	417.00
IUUC-Xtr-132002	Xenopus tropicalis	74.57	0.00e+00	850.00
IUUC-Xma-133930	Xiphophorus maculatus	70.97	0.00e+00	808.00
IUUC-Yli-134505	Yarrowia lipolytica	35.55	9.00e-86	310.00
IUUC-Zma-135895	Zea mays	42.69	6.00e-124	437.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence