iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133930

Ensembl Protein ID

ENSXMAP00000019061.1

UniProt Accession

M4AX66; M4AX66_XIPMA

Genbank Protein ID

ENSXMAP00000019061

Protein Name

NEDD8-activating enzyme E1 regulatory subunit

Genbank Nucleotide ID

AGAJ01021389

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000018987.1	ENSXMAT00000019089.1	ENSXMAP00000019061.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	3.00e-117	392.4	12	523

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YDRQ+rlwG+++qe+l++a+v+l++a+++G+E+lKnLvl G+g +t+vD++tv  ++++++F+++  ++gk++A++a e l+eln+dv+
   Q: 12   YDRQLRLWGDHGQEALENAHVCLINATATGTEILKNLVLPGIGAFTIVDGHTVAGEDVGNNFFLSSNSIGKNRAQAATELLQELNSDVS 100
           ***************************************************************************************** PP
   S: 90   veaheesiteleeeiv.FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dppqktiPfc 174
           + ++ees+++l ++++ Ff +f++V+  + ++++ +++ +++++a+vp + ++t+Gl+G++r +++++t+++s++d   +++++++Pf 
   Q: 101  GNFVEESPDKLLDNDPeFFHRFTIVIGVQLPESTCLRLGSVLWSASVPYLVCKTYGLIGYMRLVVQEHTVIESHPDnalEDLRLDQPFD 189
           ***************************************************************************************** PP
   S: 175  tlketpn.........aaehtiewavlfnklleeeageeevlekldseekeegkdkvkselks......edeenfeeaieiavkafakt 248
           ++k+++n         +++++++w+ +++k+l+ + +e++++++++++eke++++ +++++ +      edeenf+eai+++++a+++t
   Q: 190  EFKNHINsydltsmekKDHSHTPWIIIVAKYLDRWLSEHDGQPPKNYKEKESFRQMIREGILKnlngvpEDEENFDEAIKNVNTALNPT 278
           *****99999999998************************************************************************* PP
   S: 249  tins.ikqllksfecdivtkskspfwv.............................................................. 274
            i+s +++l++s +c+i t ++++fwv                                                              
   Q: 279  KIPSaVEDLFSSGQCNI-TAQSPSFWVmlravkefvhsegsgnlpvrgtipdmiadsqkfinlqniyrekalqdsaavakhvesllqsv 366
           ***************77.*********************************************************************** PP
   S: 275  .............sfcsnaealqvp...........ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekdddsavd 334
                         fc+na+ l+v            ++v+kde+++ +++p     +yl+lra++rf + ++r+pg+ ++++++d + +
   Q: 367  gkpaesiserdikLFCKNAAFLRVVccrslaeeyhvDSVNKDEITSCMDSPdsemvFYLMLRAVDRFYQLHSRYPGVYNYQVEED-ISK 454
           ***********************5566666666666999999999999999999*******************************.888 PP
   S: 335  lvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsgkfeplknfflfdae 404
           l+  + +l  ++++++ +++dd+i+e++++++++ +t++a++gG aaqE+iK++s++f+p++n+f+++a+
   Q: 455  LKLCVNSLL-QEYNLNVNIKDDYIHEFCRYGAAEPHTVSAFLGGSAAQEAIKIISHQFVPFNNTFIYNAM 523
           888888887.*********************************************************997 PP

Organism

Xiphophorus maculatus

Functional Description
(View)

Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M.

Protein Sequence
(Fasta)

MAATKGSKEQ KYDRQLRLWG DHGQEALENA HVCLINATAT GTEILKNLVL PGIGAFTIVD 60
GHTVAGEDVG NNFFLSSNSI GKNRAQAATE LLQELNSDVS GNFVEESPDK LLDNDPEFFH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACGGCCCTT GAAACCATTC AGGCAACCAG CACAACAAAG ACACAATTAA AACTGTCAGA 60
TAACTTATTA CCCCGCGATA ATAACTCAGA AATAGTCCAA ATTAGGATGT ATTTTTTCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR030667--APP-BP1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0019781--F:NEDD8 activating enzyme activity
GO:0045116--P:protein neddylation

KEGG

xma:102232122

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000764	Aegilops tauschii	40.98	2.00e-122	432.00
IUUC-Aml-002333	Ailuropoda melanoleuca	73.11	0.00e+00	838.00
IUUC-Atr-002644	Amborella trichopoda	39.85	4.00e-111	395.00
IUUC-Apl-003446	Anas platyrhynchos	71.87	0.00e+00	793.00
IUUC-Aca-004450	Anolis carolinensis	71.67	0.00e+00	810.00
IUUC-Aly-006187	Arabidopsis lyrata	40.54	7.00e-123	434.00
IUUC-Ath-007600	Arabidopsis thaliana	40.92	1.00e-124	440.00
IUUC-Ago-007900	Ashbya gossypii	26.45	2.00e-39	156.00
IUUC-Acl-008333	Aspergillus clavatus	35.78	6.00e-84	305.00
IUUC-Afl-008529	Aspergillus flavus	35.97	5.00e-84	305.00
IUUC-Afu-009071	Aspergillus fumigatus	34.71	8.00e-83	301.00
IUUC-Ani-009443	Aspergillus nidulans	33.57	1.00e-74	274.00
IUUC-Ang-009669	Aspergillus niger	34.46	4.00e-82	298.00
IUUC-Aor-009914	Aspergillus oryzae	35.83	1.00e-82	300.00
IUUC-Ate-010450	Aspergillus terreus	34.11	3.00e-81	296.00
IUUC-Ame-011183	Astyanax mexicanus	80.86	0.00e+00	935.00
IUUC-Bgr-012111	Blumeria graminis	31.02	5.00e-61	228.00
IUUC-Bta-012583	Bos taurus	73.19	0.00e+00	839.00
IUUC-Bci-013892	Botrytis cinerea	32.03	5.00e-61	228.00
IUUC-Bdi-014592	Brachypodium distachyon	41.90	2.00e-126	446.00
IUUC-Bol-016399	Brassica oleracea	40.57	8.00e-124	437.00
IUUC-Bra-017506	Brassica rapa	39.92	9.00e-121	427.00
IUUC-Cel-018456	Caenorhabditis elegans	34.75	3.00e-92	332.00
IUUC-Cja-020007	Callithrix jacchus	72.59	0.00e+00	833.00
IUUC-Cfa-020324	Canis familiaris	73.19	0.00e+00	841.00
IUUC-Cpo-022248	Cavia porcellus	62.86	5.00e-130	457.00
IUUC-Csa-023149	Chlorocebus sabaeus	69.00	0.00e+00	702.00
IUUC-Cho-024537	Choloepus hoffmanni	61.17	2.00e-172	598.00
IUUC-Cin-025763	Ciona intestinalis	47.65	1.00e-149	523.00
IUUC-Csv-026113	Ciona savignyi	45.47	1.00e-141	496.00
IUUC-Cgl-026428	Colletotrichum gloeosporioides	34.11	3.00e-68	253.00
IUUC-Cne-026884	Cryptococcus neoformans	29.00	2.00e-68	253.00
IUUC-Cme-027210	Cyanidioschyzon merolae	23.71	1.00e-16	81.30
IUUC-Dre-028140	Danio rerio	82.18	0.00e+00	939.00
IUUC-Dno-030033	Dasypus novemcinctus	72.16	0.00e+00	728.00
IUUC-Dor-030513	Dipodomys ordii	49.84	8.00e-81	294.00
IUUC-Dse-031536	Dothistroma septosporum	32.45	4.00e-78	285.00
IUUC-Dme-031683	Drosophila melanogaster	44.65	4.00e-127	448.00
IUUC-Ete-032420	Echinops telfairi	62.60	0.00e+00	681.00
IUUC-Eca-033992	Equus caballus	71.40	0.00e+00	689.00
IUUC-Eeu-034713	Erinaceus europaeus	58.66	2.00e-86	312.00
IUUC-Fca-036548	Felis catus	72.05	0.00e+00	827.00
IUUC-Fal-037600	Ficedula albicollis	70.50	0.00e+00	777.00
IUUC-Fox-038037	Fusarium oxysporum	35.77	8.00e-64	238.00
IUUC-Fso-038387	Fusarium solani	33.83	3.00e-71	262.00
IUUC-Gmo-038562	Gadus morhua	85.05	0.00e+00	959.00
IUUC-Ggr-040005	Gaeumannomyces graminis	34.94	4.00e-71	262.00
IUUC-Gga-041129	Gallus gallus	71.86	0.00e+00	803.00
IUUC-Gac-042558	Gasterosteus aculeatus	87.85	0.00e+00	987.00
IUUC-Gma-043610	Glycine max	39.81	8.00e-118	417.00
IUUC-Ggo-045611	Gorilla gorilla	72.59	0.00e+00	835.00
IUUC-Hsa-046563	Homo sapiens	72.81	0.00e+00	838.00
IUUC-Hvu-047790	Hordeum vulgare	37.37	4.00e-77	281.00
IUUC-Itr-048066	Ictidomys tridecemlineatus	72.81	0.00e+00	831.00
IUUC-Kpa-049309	Komagataella pastoris	32.95	9.00e-75	274.00
IUUC-Lch-050038	Latimeria chalumnae	73.60	0.00e+00	842.00
IUUC-Lpe-051535	Leersia perrieri	41.16	2.00e-108	386.00
IUUC-Loc-051917	Lepisosteus oculatus	75.79	0.00e+00	842.00
IUUC-Lma-053112	Leptosphaeria maculans	33.93	7.00e-85	308.00
IUUC-Laf-053690	Loxodonta africana	72.97	0.00e+00	842.00
IUUC-Mcc-055117	Macaca mulatta	71.32	0.00e+00	820.00
IUUC-Meu-056761	Macropus eugenii	60.86	0.00e+00	664.00
IUUC-Mor-057230	Magnaporthe oryzae	33.58	9.00e-77	281.00
IUUC-Mpo-057514	Magnaporthe poae	33.94	1.00e-69	257.00
IUUC-Mtr-058551	Medicago truncatula	38.81	3.00e-114	405.00
IUUC-Mla-059183	Melampsora laricipopulina	36.28	8.00e-98	351.00
IUUC-Mga-060144	Meleagris gallopavo	70.80	0.00e+00	785.00
IUUC-Mvi-060221	Microbotryum violaceum	34.44	1.00e-78	287.00
IUUC-Mmr-061325	Microcebus murinus	71.46	0.00e+00	819.00
IUUC-Mdo-062532	Monodelphis domestica	74.10	0.00e+00	845.00
IUUC-Mmu-063956	Mus musculus	73.19	0.00e+00	838.00
IUUC-Mac-064521	Musa acuminata	39.39	2.00e-118	419.00
IUUC-Mpu-066716	Mustela putorius furo	72.27	0.00e+00	784.00
IUUC-Mlu-067459	Myotis lucifugus	72.02	0.00e+00	830.00
IUUC-Nfi-068245	Neosartorya fischeri	35.07	7.00e-83	301.00
IUUC-Ncr-068910	Neurospora crassa	32.60	9.00e-74	271.00
IUUC-Nle-070034	Nomascus leucogenys	70.29	0.00e+00	805.00
IUUC-Opr-070552	Ochotona princeps	68.15	0.00e+00	692.00
IUUC-Ont-071426	Oreochromis niloticus	91.37	0.00e+00	1023.00
IUUC-Oan-073389	Ornithorhynchus anatinus	69.82	0.00e+00	650.00
IUUC-Ocu-074911	Oryctolagus cuniculus	73.38	0.00e+00	838.00
IUUC-Oba-075437	Oryza barthii	41.49	3.00e-115	409.00
IUUC-Obr-076684	Oryza brachyantha	41.56	3.00e-110	392.00
IUUC-Ogl-077170	Oryza glaberrima	41.49	3.00e-115	409.00
IUUC-Ogu-078844	Oryza glumaepatula	41.92	1.00e-107	383.00
IUUC-Oin-079105	Oryza indica	41.49	1.00e-114	407.00
IUUC-Olo-080943	Oryza longistaminata	39.16	2.00e-102	366.00
IUUC-Oni-082891	Oryza nivara	38.62	2.00e-108	386.00
IUUC-Opu-083457	Oryza punctata	41.49	1.00e-114	406.00
IUUC-Oru-084960	Oryza rufipogon	38.98	8.00e-104	370.00
IUUC-Osa-085358	Oryza sativa	41.68	2.00e-115	409.00
IUUC-Ola-086420	Oryzias latipes	86.60	0.00e+00	677.00
IUUC-Olu-087625	Ostreococcus lucimarinus	29.05	2.00e-60	227.00
IUUC-Oga-088810	Otolemur garnettii	73.38	0.00e+00	839.00
IUUC-Oar-089196	Ovis aries	72.97	0.00e+00	834.00
IUUC-Ptr-090617	Pan troglodytes	73.00	0.00e+00	839.00
IUUC-Pan-092761	Papio anubis	73.00	0.00e+00	839.00
IUUC-Psi-093191	Pelodiscus sinensis	72.15	0.00e+00	818.00
IUUC-Pma-094380	Petromyzon marinus	62.47	0.00e+00	667.00
IUUC-Pno-095084	Phaeosphaeria nodorum	34.05	1.00e-73	272.00
IUUC-Ppa-095875	Physcomitrella patens	40.26	3.00e-118	418.00
IUUC-Pfo-096467	Poecilia formosa	97.95	0.00e+00	1086.00
IUUC-Pab-098255	Pongo abelii	72.25	0.00e+00	692.00
IUUC-Pop-099722	Populus trichocarpa	40.54	3.00e-121	428.00
IUUC-Pca-100807	Procavia capensis	61.89	8.00e-94	337.00
IUUC-Ppe-101280	Prunus persica	39.81	3.00e-121	428.00
IUUC-Pva-102333	Pteropus vampyrus	70.89	0.00e+00	795.00
IUUC-Pgr-103401	Puccinia graminis	31.09	5.00e-77	281.00
IUUC-Ptt-103889	Puccinia triticina	27.38	6.00e-57	215.00
IUUC-Pte-104355	Pyrenophora teres	35.05	7.00e-85	308.00
IUUC-Pyt-104545	Pyrenophora triticirepentis	34.40	8.00e-86	311.00
IUUC-Rno-105810	Rattus norvegicus	73.38	0.00e+00	833.00
IUUC-Sha-106770	Sarcophilus harrisii	76.62	3.00e-130	457.00
IUUC-Sja-107926	Schizosaccharomyces japonicus	32.65	1.00e-73	270.00
IUUC-Spo-108276	Schizosaccharomyces pombe	33.90	2.00e-79	289.00
IUUC-Ssl-108387	Sclerotinia sclerotiorum	33.83	2.00e-65	243.00
IUUC-Smo-109296	Selaginella moellendorffii	41.67	7.00e-121	427.00
IUUC-Sit-110157	Setaria italica	41.73	2.00e-128	452.00
IUUC-Sly-111105	Solanum lycopersicum	38.53	3.00e-117	415.00
IUUC-Stu-112469	Solanum tuberosum	38.72	5.00e-118	418.00
IUUC-Sar-113083	Sorex araneus	55.04	2.00e-169	588.00
IUUC-Sbi-113813	Sorghum bicolor	42.24	2.00e-127	449.00
IUUC-Sre-115058	Sporisorium reilianum	37.03	4.00e-78	285.00
IUUC-Tgu-116772	Taeniopygia guttata	70.97	0.00e+00	789.00
IUUC-Tru-118686	Takifugu rubripes	85.55	0.00e+00	971.00
IUUC-Tsy-119111	Tarsius syrichta	70.55	3.00e-116	411.00
IUUC-Tni-120231	Tetraodon nigroviridis	79.48	0.00e+00	880.00
IUUC-Tca-121491	Theobroma cacao	39.28	6.00e-114	404.00
IUUC-Tre-122103	Trichoderma reesei	34.26	2.00e-78	286.00
IUUC-Tvi-122672	Trichoderma virens	34.26	7.00e-73	268.00
IUUC-Tae-125679	Triticum aestivum	41.56	1.00e-124	440.00
IUUC-Tur-126487	Triticum urartu	40.38	3.00e-118	418.00
IUUC-Tme-127097	Tuber melanosporum	36.82	4.00e-90	325.00
IUUC-Ttr-128465	Tursiops truncatus	68.62	0.00e+00	771.00
IUUC-Uma-129645	Ustilago maydis	33.11	2.00e-85	310.00
IUUC-Vda-129989	Verticillium dahliae	30.54	9.00e-57	214.00
IUUC-Vpa-130529	Vicugna pacos	70.13	0.00e+00	790.00
IUUC-Vvi-131059	Vitis vinifera	40.19	2.00e-120	426.00
IUUC-Xtr-132002	Xenopus tropicalis	72.42	0.00e+00	825.00
IUUC-Yli-134505	Yarrowia lipolytica	32.63	1.00e-81	297.00
IUUC-Zma-135895	Zea mays	42.10	8.00e-126	444.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence