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Tag Content
UUCD2 ID IUUC-Itr-048147
UUCD1 version UUC-SpT-00742
Ensembl Protein ID ENSSTOP00000002124.2
UniProt Accession I3M0A6; I3M0A6_ICTTR
Genbank Protein ID ENSSTOP00000002124
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AGTP01061910
Gene Name USP13
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSTOG00000002367.2 ENSSTOT00000002374.2 ENSSTOP00000002124.2
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 9.30e-57 192.7 327 864
UBD/Alpha-Helix/UBA 1.00e-20 73.2 734 771
Active Site
Position(s) Description Evidence
336 Nucleophile {ECO:0000256|PIRSR:PIRSR016308-1}
827 Proton acceptor {ECO:0000256|PIRSR:PIRSR016308-1}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel.......................wkskkk 66
           tGlkNlgN+CY+ Sv+Q++++ipe+++++  + ++ ++ + p +p++++ ++++kl + l                       ++ +++
   Q: 327  TGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYS-PLDPTQDFNTQMTKLGHGLlsgqyskppgipdhrnwpwtsmrTQPQQN 414
           7******************************788877765.79*****************99999999999999998755544388888 PP
   S: 67   avsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqik 155
            +spr++++ ++k ++efs+++qqDaqEf+ +l++ +e++                               +++  sd+F++ ++++i+
   Q: 415  GISPRMFKAFVSKSHPEFSSNRQQDAQEFFLHLVHLVERNR-----------------------------IGSENPSDVFRFLVEERIQ 474
           *************************************9998.............................788899************* PP
   S: 156  clecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqea 217
           c + ++v  +e   + ++lpv ++  t+k                             ++ cL++f+++e++++   ++++  ++k+  
   Q: 475  CCQTRKVRYTERVDYLMQLPVAMEAATNKDeliayeltrreaeanrrplpelvrakiPFSACLQAFSEPENVDD---FWSSALQAKSAG 560
           *******9999999999999999998887799****************************************97...************ PP
   S: 218  ekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts....................................... 267
           +k+ ++ ++P++L++++k+f+f  + ++++k++ ++++p+ Ld+s+  ++                                       
   Q: 561  VKTSRFASFPDYLVVQIKKFTFGLD-WVPKKFDVSIDMPDLLDISHLRARglqpgeeelpdisppivipddskgsrtlgihnsedcsgl 648
           **********************997.*******************99988999999999999999999988888888888888888888 PP
   S: 268  ......................................................................................... 267
                                                                                                    
   Q: 649  cgalrasdidessvmqlaemgfpleacrkavyftgnmgaevafnwiivhmeepdfaepltipgyggaasagaslfgatgldnqppeeiv 737
           88888888888888888888887777777777777777777777777777777777777777777777777777777777777766666 PP
   S: 268  .......................peekqke............................................kkkYeLiavvvHsG. 288
                                        e                                            +  YeL+a ++H+G 
   Q: 738  aiitsmgfqrnqavqalratnnnL-----EraldwifshpefeedsdfviemennananiiseakpegprvkdgSGMYELFAFISHMGt 821
           666666666666666665555550.....055555555555555556666666666677788888888888888*************** PP
   S: 289  slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           s+ sGHYv+++k+ +g+W+ ++D+kV ++  e+  +   + +Y++fY+r
   Q: 822  STMSGHYVCHIKK-EGRWVIYNDHKVCAS--ERPPK---DLGYLYFYRR 864
           *************.9***********999..78888...89******97 PP
   

   UBD/Alpha-Helix/UBA
   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r++a+qaLra+nnnle+A+++++++
   Q: 734  EEIVAIITSMGFQRNQAVQALRATNNNLERALDWIFSH 771
           899*********************************97 PP
   
Organism Ictidomys tridecemlineatus
Protein Sequence
(Fasta)
LTGVSEVCFF VIGGLVFIEK NAKQNYKDEN TYKQLAVNSE GGLYVCMNTF LAFGREHVER 60
HFRKTGQSVY MHLKRHVREE WRSKEKVRGA SGGALPKRRN SKIFLDLDTD DDLNSDDYEY 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Itr-048147|DUB,USP;UBD,UBA|Ictidomys tridecemlineatus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGACAGGTG TTTCAGAAGT CTGTTTTTTT GTTATCGGAG GGGTGAGATT AACAGAAGCT 60
TAATGAAATC CACTTCCTTG GAGGAAAGGT GTCTGCTTTC ATAGCTTGTG TTTATAGAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Itr-048147|DUB,USP;UBD,UBA|Ictidomys tridecemlineatus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP
SMART

SM00165--UBA
SM00290--ZnF_UBP
Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001356 Ailuropoda melanoleuca 89.07 0.00e+00 1426.00
IUUC-Apl-003712 Anas platyrhynchos 78.90 0.00e+00 1286.00
IUUC-Aca-004634 Anolis carolinensis 79.42 0.00e+00 1276.00
IUUC-Ame-011470 Astyanax mexicanus 69.17 0.00e+00 1165.00
IUUC-Bta-013349 Bos taurus 88.50 0.00e+00 1458.00
IUUC-Cja-019021 Callithrix jacchus 88.03 0.00e+00 1414.00
IUUC-Cfa-020614 Canis familiaris 89.19 0.00e+00 1431.00
IUUC-Cpo-022484 Cavia porcellus 91.45 0.00e+00 1429.00
IUUC-Csa-024078 Chlorocebus sabaeus 89.32 0.00e+00 1432.00
IUUC-Cho-024522 Choloepus hoffmanni 77.23 0.00e+00 1119.00
IUUC-Cme-027335 Cyanidioschyzon merolae 25.90 6.00e-52 199.00
IUUC-Dre-027651 Danio rerio 69.63 0.00e+00 1234.00
IUUC-Dno-028975 Dasypus novemcinctus 89.11 0.00e+00 1430.00
IUUC-Dor-030130 Dipodomys ordii 73.28 0.00e+00 805.00
IUUC-Ete-032251 Echinops telfairi 75.90 0.00e+00 1199.00
IUUC-Eca-033568 Equus caballus 91.57 0.00e+00 1431.00
IUUC-Fca-036280 Felis catus 91.31 0.00e+00 1427.00
IUUC-Fal-036610 Ficedula albicollis 80.58 0.00e+00 1265.00
IUUC-Gmo-038906 Gadus morhua 67.71 0.00e+00 1138.00
IUUC-Gga-041215 Gallus gallus 78.04 0.00e+00 1285.00
IUUC-Gac-042441 Gasterosteus aculeatus 67.33 0.00e+00 1157.00
IUUC-Ggo-044446 Gorilla gorilla 89.20 0.00e+00 1434.00
IUUC-Hsa-046546 Homo sapiens 89.32 0.00e+00 1433.00
IUUC-Lch-050425 Latimeria chalumnae 73.01 0.00e+00 1236.00
IUUC-Loc-052072 Lepisosteus oculatus 72.20 0.00e+00 1179.00
IUUC-Laf-053909 Loxodonta africana 87.95 0.00e+00 1422.00
IUUC-Mcc-054686 Macaca mulatta 89.32 0.00e+00 1434.00
IUUC-Meu-056361 Macropus eugenii 80.60 0.00e+00 970.00
IUUC-Mga-059972 Meleagris gallopavo 78.80 0.00e+00 1267.00
IUUC-Mmr-060916 Microcebus murinus 88.38 0.00e+00 1424.00
IUUC-Mdo-062302 Monodelphis domestica 82.46 0.00e+00 1362.00
IUUC-Mmu-063639 Mus musculus 87.44 0.00e+00 1459.00
IUUC-Mpu-066533 Mustela putorius furo 89.42 0.00e+00 1433.00
IUUC-Mlu-067786 Myotis lucifugus 86.64 0.00e+00 1375.00
IUUC-Nle-069997 Nomascus leucogenys 92.69 0.00e+00 1411.00
IUUC-Ont-071859 Oreochromis niloticus 68.66 0.00e+00 1197.00
IUUC-Oan-072959 Ornithorhynchus anatinus 88.39 1.00e-120 424.00
IUUC-Ocu-074265 Oryctolagus cuniculus 89.55 0.00e+00 1436.00
IUUC-Ola-087344 Oryzias latipes 67.94 0.00e+00 1184.00
IUUC-Oga-088734 Otolemur garnettii 88.85 0.00e+00 1422.00
IUUC-Oar-089636 Ovis aries 91.93 0.00e+00 1487.00
IUUC-Ptr-090982 Pan troglodytes 89.32 0.00e+00 1436.00
IUUC-Pan-091991 Papio anubis 89.44 0.00e+00 1435.00
IUUC-Psi-093509 Pelodiscus sinensis 81.17 0.00e+00 1314.00
IUUC-Pfo-096029 Poecilia formosa 69.00 0.00e+00 1206.00
IUUC-Pab-098672 Pongo abelii 85.56 0.00e+00 1347.00
IUUC-Pva-102545 Pteropus vampyrus 81.69 0.00e+00 1299.00
IUUC-Rno-105210 Rattus norvegicus 86.74 0.00e+00 1436.00
IUUC-Sar-113733 Sorex araneus 89.88 0.00e+00 720.00
IUUC-Tgu-116591 Taeniopygia guttata 79.65 0.00e+00 1296.00
IUUC-Tru-118627 Takifugu rubripes 67.78 0.00e+00 1192.00
IUUC-Tsy-119278 Tarsius syrichta 82.53 0.00e+00 1272.00
IUUC-Tni-120804 Tetraodon nigroviridis 68.55 0.00e+00 1191.00
IUUC-Ttr-128295 Tursiops truncatus 82.11 0.00e+00 1283.00
IUUC-Vpa-130170 Vicugna pacos 80.12 0.00e+00 1249.00
IUUC-Xtr-132809 Xenopus tropicalis 69.17 0.00e+00 1143.00
Created Date 25-Jun-2017

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