iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010731

Ensembl Protein ID

ENSAMXP00000006437.1

UniProt Accession

W5KFS6; W5KFS6_ASTMX

Genbank Protein ID

ENSAMXP00000006437

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

APWO01101102

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000006267.1	ENSAMXT00000006437.1	ENSAMXP00000006437.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	57.42	6.00e-136	482.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Astyanax mexicanus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

VVMSSEQAHA EAAGGSRQRR RSNSRQGSEL ELELTPKVSP MYPEEGGISS TVHFLDGAYE 60
YHNPASGVGS SPVGFYPPPP DPQLPLAEET LQSLASGSAS PLVFVSSSPQ PPTYLTHAGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGAAGGG TAGGGGAAAG AGAAAGAGAA AAATCCCTTT CTCTTAGTCA GAGTGTGAGA 60
GCAGCTGGTG CTGTAAGTCA TGCTGCCTGT GTGTGTGTGT GTGTTTGTGT GGTGATGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	60.38	2.00e-129	456.00
IUUC-Apl-003688	Anas platyrhynchos	52.12	3.00e-126	445.00
IUUC-Aca-005222	Anolis carolinensis	51.51	3.00e-129	455.00
IUUC-Bta-013112	Bos taurus	57.65	2.00e-129	456.00
IUUC-Cja-019408	Callithrix jacchus	57.43	4.00e-133	468.00
IUUC-Cfa-020694	Canis familiaris	58.89	2.00e-132	466.00
IUUC-Cpo-021426	Cavia porcellus	57.30	6.00e-128	451.00
IUUC-Csa-023736	Chlorocebus sabaeus	58.32	9.00e-133	466.00
IUUC-Dre-027698	Danio rerio	70.67	0.00e+00	701.00
IUUC-Dno-029477	Dasypus novemcinctus	56.70	3.00e-128	452.00
IUUC-Dor-030572	Dipodomys ordii	58.47	1.00e-123	436.00
IUUC-Ete-032849	Echinops telfairi	47.34	2.00e-87	315.00
IUUC-Eca-033605	Equus caballus	58.45	2.00e-128	452.00
IUUC-Eeu-034683	Erinaceus europaeus	55.75	2.00e-57	216.00
IUUC-Fca-035928	Felis catus	59.76	4.00e-126	444.00
IUUC-Fal-036754	Ficedula albicollis	51.72	3.00e-135	475.00
IUUC-Gmo-038872	Gadus morhua	64.77	5.00e-136	477.00
IUUC-Gga-040988	Gallus gallus	52.38	5.00e-134	471.00
IUUC-Gac-042015	Gasterosteus aculeatus	64.55	1.00e-155	543.00
IUUC-Ggo-044749	Gorilla gorilla	57.78	3.00e-133	468.00
IUUC-Hsa-046944	Homo sapiens	57.56	4.00e-133	468.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	57.56	2.00e-132	466.00
IUUC-Loc-052414	Lepisosteus oculatus	63.12	5.00e-174	603.00
IUUC-Mcc-054781	Macaca mulatta	57.78	3.00e-133	468.00
IUUC-Meu-056232	Macropus eugenii	57.56	4.00e-126	444.00
IUUC-Mga-059319	Meleagris gallopavo	52.38	3.00e-134	471.00
IUUC-Mmr-061636	Microcebus murinus	52.71	5.00e-63	234.00
IUUC-Mdo-062661	Monodelphis domestica	59.02	2.00e-130	459.00
IUUC-Mmu-063330	Mus musculus	58.22	3.00e-132	465.00
IUUC-Mpu-065757	Mustela putorius furo	59.33	8.00e-134	470.00
IUUC-Mlu-067712	Myotis lucifugus	56.70	1.00e-130	460.00
IUUC-Nle-069283	Nomascus leucogenys	59.11	2.00e-133	469.00
IUUC-Opr-070391	Ochotona princeps	56.44	2.00e-132	466.00
IUUC-Ont-071369	Oreochromis niloticus	60.77	7.00e-145	507.00
IUUC-Oan-073734	Ornithorhynchus anatinus	45.63	7.00e-54	204.00
IUUC-Ocu-074292	Oryctolagus cuniculus	56.32	5.00e-130	457.00
IUUC-Ola-087052	Oryzias latipes	63.96	2.00e-160	558.00
IUUC-Oga-088586	Otolemur garnettii	58.00	2.00e-132	465.00
IUUC-Oar-090156	Ovis aries	59.05	8.00e-131	460.00
IUUC-Ptr-091321	Pan troglodytes	57.78	3.00e-133	468.00
IUUC-Pan-092851	Papio anubis	57.78	3.00e-133	468.00
IUUC-Psi-093434	Pelodiscus sinensis	57.48	8.00e-138	484.00
IUUC-Pfo-097379	Poecilia formosa	64.81	1.00e-152	533.00
IUUC-Pab-097735	Pongo abelii	57.78	3.00e-133	468.00
IUUC-Pva-102125	Pteropus vampyrus	58.17	7.00e-127	447.00
IUUC-Rno-106121	Rattus norvegicus	58.00	5.00e-132	464.00
IUUC-Sha-107547	Sarcophilus harrisii	52.58	3.00e-129	455.00
IUUC-Sar-113650	Sorex araneus	50.46	1.00e-74	273.00
IUUC-Tgu-117175	Taeniopygia guttata	52.26	7.00e-136	477.00
IUUC-Tru-117545	Takifugu rubripes	62.48	7.00e-163	568.00
IUUC-Tsy-119586	Tarsius syrichta	57.59	1.00e-105	376.00
IUUC-Tni-120121	Tetraodon nigroviridis	65.03	4.00e-166	578.00
IUUC-Tbe-127548	Tupaia belangeri	51.20	1.00e-98	353.00
IUUC-Ttr-128374	Tursiops truncatus	55.31	2.00e-118	419.00
IUUC-Vpa-130464	Vicugna pacos	49.09	1.00e-79	290.00
IUUC-Xtr-132171	Xenopus tropicalis	55.91	8.00e-127	447.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence