iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Post-translational Modifications (PTMs)
dbPPT	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	12969426

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	7.10e-111	371.7	1135	1502

Active Site

Position(s)	Description	Evidence
1469	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf............lysen..dketlqpnpdsglknp.ehlklFeflGrllgkalqd 84
           ++k ++eve+++E g++l G+t+ef++l+s+++qnpdlg++            ++s    +++ l+p+p+sg++++ ++l+ F +lG++++kalqd
   Q: 1135 NQKVVIEVEYSEEVGTGL-GPTLEFYTLVSRAFQNPDLGMWrndcsfivgkpvEHSGVlaSSSGLFPRPWSGTSTTsDVLQKFVLLGTVVAKALQD 1229
           67889*************.**********************9999999998865555587889999999999876679****************** PP
   S: 85   grlldlplsksfyklllgkklsledleevdpelykslkeikena.........esdieelgldltfs..vseei.....lgetkeeeLkpgGenip 164
           gr+ldlplsk+fykl+lg++ls  d++ vdpel+k+l e+++++         + d+ ++++dl+f+  + e++     l+ +++++L p ++n +
   Q: 1230 GRVLDLPLSKAFYKLILGQELSSFDIHFVDPELCKTLVELQALVrrkklfaeaHGDSGAAKCDLSFHgtKIEDLclefaLPGYTDYDLAPYSANDM 1325
           *****************************************999666666655226666666666663255555888889**************** PP
   S: 165  VtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsse 259
           V+ +N+eeY+k +v++++++gi++qveafr+Gfn+v+++e+l++F+eeele+++cGe + ++++++ +++k+++gyt++sp +++++++l+ef++e
   Q: 1326 VNLDNLEEYIKGIVNATVCNGIQKQVEAFRSGFNQVFSIEHLRIFNEEELETMLCGEcDLFSMNEVLDHIKFDHGYTSSSPPVEYLLQILHEFDRE 1421
           *********************************************************9************************************** PP
   S: 260  erkafLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFels 336
           +++afLqFvTgs+rlP+gG+a+l+p+l+++rk   d+sd++lPs++TC+nyLkLP+Ysske++kekL+yAi+e+  +F+ls
   Q: 1422 QQRAFLQFVTGSPRLPHGGLASLSPKLTIVRKhgsDSSDTDLPSVMTCANYLKLPPYSSKEKMKEKLIYAITEGqGSFHLS 1502
           **********************************99999***********************************9999985 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MENRGQKRME VVEELPADKR ACNSQDFRPS TSGSSVQAQA NDTNPGHENV DADMDTSSSA 60
SPSSRSDEEE QEEQDKEDSD YGSCDSDEED PRQRVLQDYQ RQRSSGDHGK LKSLLLNLTG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAAACATTTT AGAAGTCTGG TCTAATTAAC AAACCAGCGT CTTAGCAAAT AAGCTAAAGA 60
AAAAAAAAAG TATATACATA CACACACATA GTATATATAT ATATATTATG TGTGGATTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ath:AT5G02880

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000935	Aegilops tauschii	44.20	0.00e+00	1056.00
IUUC-Atr-002515	Amborella trichopoda	49.69	4.00e-159	555.00
IUUC-Aca-004521	Anolis carolinensis	36.08	1.00e-42	169.00
IUUC-Aly-006493	Arabidopsis lyrata	91.88	0.00e+00	2704.00
IUUC-Bdi-014101	Brachypodium distachyon	44.52	0.00e+00	1120.00
IUUC-Bol-015440	Brassica oleracea	81.48	0.00e+00	2392.00
IUUC-Bra-016648	Brassica rapa	82.70	0.00e+00	2248.00
IUUC-Dno-029954	Dasypus novemcinctus	36.43	7.00e-43	170.00
IUUC-Gma-043952	Glycine max	55.10	0.00e+00	1560.00
IUUC-Hvu-047811	Hordeum vulgare	44.67	0.00e+00	1133.00
IUUC-Lpe-051509	Leersia perrieri	44.05	0.00e+00	1106.00
IUUC-Mtr-058626	Medicago truncatula	54.19	0.00e+00	1533.00
IUUC-Mac-065046	Musa acuminata	44.63	0.00e+00	1119.00
IUUC-Oba-075380	Oryza barthii	44.05	0.00e+00	1044.00
IUUC-Obr-076904	Oryza brachyantha	44.27	0.00e+00	1112.00
IUUC-Ogl-076926	Oryza glaberrima	45.02	0.00e+00	1125.00
IUUC-Ogu-078892	Oryza glumaepatula	45.33	0.00e+00	1093.00
IUUC-Oin-079148	Oryza indica	42.76	0.00e+00	1026.00
IUUC-Olo-081086	Oryza longistaminata	43.25	0.00e+00	1003.00
IUUC-Ome-081955	Oryza meridionalis	43.58	0.00e+00	1073.00
IUUC-Oni-083047	Oryza nivara	43.58	0.00e+00	1062.00
IUUC-Opu-083641	Oryza punctata	44.25	0.00e+00	1074.00
IUUC-Oru-084439	Oryza rufipogon	44.09	0.00e+00	1042.00
IUUC-Osa-085605	Oryza sativa	36.08	0.00e+00	725.00
IUUC-Pop-099725	Populus trichocarpa	57.10	0.00e+00	1614.00
IUUC-Ppe-101229	Prunus persica	56.76	0.00e+00	1619.00
IUUC-Sce-106273	Saccharomyces cerevisiae	36.89	2.00e-77	284.00
IUUC-Sit-110332	Setaria italica	45.43	0.00e+00	1143.00
IUUC-Sly-111552	Solanum lycopersicum	50.35	0.00e+00	1377.00
IUUC-Sbi-114106	Sorghum bicolor	43.55	0.00e+00	1101.00
IUUC-Tgu-117167	Taeniopygia guttata	36.43	6.00e-43	169.00
IUUC-Tca-121574	Theobroma cacao	55.85	0.00e+00	1623.00
IUUC-Tae-125470	Triticum aestivum	45.40	0.00e+00	1137.00
IUUC-Tur-126486	Triticum urartu	44.30	0.00e+00	1064.00
IUUC-Vvi-130904	Vitis vinifera	52.63	0.00e+00	1462.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence