iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-022077

Ensembl Protein ID

ENSCPOP00000006044.2

UniProt Accession

H0V8E6; H0V8E6_CAVPO

Genbank Protein ID

ENSCPOP00000006044

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02007941

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000006709.3	ENSCPOT00000006777.2	ENSCPOP00000006044.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-34	116.9	118	155
UBD/Beta-Prp	1.10e-51	175.8	217	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 118  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 155
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 217  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 305
           67899***********999999999988988555547777888765522777788**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 306  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqtlqgiEDKITKMKVTMVAWDRHDNNVITAVNNMTLKVWNSYTGQ 394
           ********************************99************999888888999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 395  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 478
           ******9.*********999999..89******************999988875544445566667777999999999999988887 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCKHVVWKGS 60
ALAALHCGRP PESPVNYGSP PSIADTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAGTATT ATAGACATCT AGCACCTGAT CACTTACTGC AAATATGTCA TCGACTAGGA 60
CCTCTTCTTG AACAAGAAAT TCCTCAAAGT GTTCCTGGAG TACAGACTTT ATTAGGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0103--Bromodomain
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002299	Ailuropoda melanoleuca	90.42	0.00e+00	2979.00
IUUC-Apl-003700	Anas platyrhynchos	82.30	0.00e+00	2732.00
IUUC-Aca-004474	Anolis carolinensis	77.68	0.00e+00	2603.00
IUUC-Bta-013125	Bos taurus	97.25	0.00e+00	1595.00
IUUC-Cja-018868	Callithrix jacchus	90.42	0.00e+00	3053.00
IUUC-Cfa-021179	Canis familiaris	90.70	0.00e+00	2916.00
IUUC-Csa-023618	Chlorocebus sabaeus	97.38	0.00e+00	1625.00
IUUC-Cho-024794	Choloepus hoffmanni	88.60	0.00e+00	856.00
IUUC-Dre-028029	Danio rerio	80.59	0.00e+00	1254.00
IUUC-Dno-030048	Dasypus novemcinctus	96.75	0.00e+00	1577.00
IUUC-Dor-030195	Dipodomys ordii	88.80	0.00e+00	1451.00
IUUC-Eca-034274	Equus caballus	97.13	0.00e+00	1584.00
IUUC-Eeu-034688	Erinaceus europaeus	92.83	0.00e+00	1287.00
IUUC-Fca-035451	Felis catus	89.53	0.00e+00	2871.00
IUUC-Fal-037465	Ficedula albicollis	81.68	0.00e+00	2692.00
IUUC-Gmo-039451	Gadus morhua	59.05	3.00e-176	612.00
IUUC-Gga-040798	Gallus gallus	81.55	0.00e+00	2726.00
IUUC-Ggo-045347	Gorilla gorilla	90.93	0.00e+00	3051.00
IUUC-Hsa-046757	Homo sapiens	97.50	0.00e+00	1599.00
IUUC-Hvu-047706	Hordeum vulgare	32.12	8.00e-38	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	92.05	0.00e+00	1169.00
IUUC-Lch-050646	Latimeria chalumnae	74.63	0.00e+00	2524.00
IUUC-Loc-052672	Lepisosteus oculatus	67.06	0.00e+00	2220.00
IUUC-Laf-054140	Loxodonta africana	89.44	0.00e+00	3049.00
IUUC-Mcc-055061	Macaca mulatta	97.50	0.00e+00	1625.00
IUUC-Mmr-060837	Microcebus murinus	97.26	0.00e+00	1566.00
IUUC-Mdo-061903	Monodelphis domestica	93.88	0.00e+00	1577.00
IUUC-Mmu-063772	Mus musculus	89.97	0.00e+00	3002.00
IUUC-Mpu-066359	Mustela putorius furo	90.21	0.00e+00	2772.00
IUUC-Mlu-067928	Myotis lucifugus	90.36	0.00e+00	3027.00
IUUC-Nle-070094	Nomascus leucogenys	97.50	0.00e+00	1598.00
IUUC-Opr-070971	Ochotona princeps	73.28	0.00e+00	939.00
IUUC-Ont-072221	Oreochromis niloticus	75.77	0.00e+00	1224.00
IUUC-Oan-073185	Ornithorhynchus anatinus	93.27	0.00e+00	1564.00
IUUC-Ocu-074033	Oryctolagus cuniculus	90.04	0.00e+00	2709.00
IUUC-Ogu-078641	Oryza glumaepatula	24.38	1.00e-29	126.00
IUUC-Oin-079669	Oryza indica	31.34	4.00e-52	199.00
IUUC-Olo-080755	Oryza longistaminata	31.65	3.00e-54	207.00
IUUC-Oni-082991	Oryza nivara	27.78	2.00e-39	158.00
IUUC-Oga-088578	Otolemur garnettii	97.51	0.00e+00	1593.00
IUUC-Oar-090247	Ovis aries	97.63	0.00e+00	1598.00
IUUC-Ptr-091266	Pan troglodytes	96.88	0.00e+00	1577.00
IUUC-Pan-092734	Papio anubis	97.50	0.00e+00	1626.00
IUUC-Pfo-096191	Poecilia formosa	68.90	0.00e+00	1875.00
IUUC-Pab-098402	Pongo abelii	97.38	0.00e+00	1595.00
IUUC-Pop-099185	Populus trichocarpa	35.42	8.00e-71	263.00
IUUC-Pca-101128	Procavia capensis	90.76	0.00e+00	1457.00
IUUC-Pva-103058	Pteropus vampyrus	88.47	0.00e+00	1431.00
IUUC-Rno-106013	Rattus norvegicus	94.51	0.00e+00	1575.00
IUUC-Sha-107496	Sarcophilus harrisii	94.01	0.00e+00	1579.00
IUUC-Sar-113520	Sorex araneus	84.75	0.00e+00	1395.00
IUUC-Ssc-115461	Sus scrofa	85.45	0.00e+00	2842.00
IUUC-Tgu-116821	Taeniopygia guttata	81.56	0.00e+00	2694.00
IUUC-Tru-117625	Takifugu rubripes	68.19	0.00e+00	1876.00
IUUC-Tsy-119132	Tarsius syrichta	86.72	0.00e+00	1310.00
IUUC-Tni-120716	Tetraodon nigroviridis	66.44	0.00e+00	1853.00
IUUC-Tbe-127479	Tupaia belangeri	86.46	0.00e+00	1315.00
IUUC-Ttr-128427	Tursiops truncatus	90.39	0.00e+00	1488.00
IUUC-Vpa-130160	Vicugna pacos	97.00	0.00e+00	1588.00
IUUC-Xtr-132717	Xenopus tropicalis	70.37	0.00e+00	2348.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence