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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045758
Ensembl Protein ID ENSP00000476746.1
UniProt Accession P24278; B3KUX6; Q8IYH9; ZBT25_HUMAN
Genbank Protein ID CAA34595.1; BAG53588.1; EAW80861.1; AAH35804.1
Protein Name Zinc finger and BTB domain-containing protein 25; Zinc finger protein 46; Zinc finger protein KUP
Genbank Nucleotide ID X16576; AK098181; CH471061; BC035804
Gene Name ZBTB25; C14orf51; KUP; ZNF46
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000089775.11 ENST00000555220.5 ENSP00000450718.1
ENSG00000089775.11 ENST00000555424.1 ENSP00000451046.1
ENSG00000089775.11 ENST00000608382.5 ENSP00000476746.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 1.30e-11 46.4 24 84
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik..dvqpevfrallkFlYtgk 64
           +D+++ +g+++f+ah++vLaa S +F+  f ++ +e      ++i+  d+qp+ f+ ll+ +Ytgk
   Q: 24   CDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQTSEC-----IKIQptDIQPDIFSYLLHIMYTGK 84
           8*****************************9987775.....7777769****************8 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MDTASHSLVL LQQLNMQREF GFLCDCTVAI GDVYFKAHRA VLAAFSNYFK MIFIHQTSEC 60
IKIQPTDIQP DIFSYLLHIM YTGKGPKQIV DHSRLEEGIR FLHADYLSHI ATEMNQVFSP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045758|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAAGAAGGTA ACTAATTTGG GAACTAGTCT CCGTAGGGGC TTCGCCTCCG ACTCAGGGAG 60
GCCGCACGCC CGGGACCTGA CGCGCCGGCA ACAAGCAGGC GGCCTGGCAG CCGCCCGTCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045758|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0010467--P:gene expression
GO:0006351--P:transcription, DNA-templated
KEGG hsa:7597
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001351 Ailuropoda melanoleuca 94.25 0.00e+00 835.00
IUUC-Apl-003334 Anas platyrhynchos 69.16 2.00e-165 575.00
IUUC-Aca-004964 Anolis carolinensis 69.93 0.00e+00 628.00
IUUC-Bta-012769 Bos taurus 94.71 0.00e+00 824.00
IUUC-Cja-018836 Callithrix jacchus 97.47 0.00e+00 884.00
IUUC-Cfa-020444 Canis familiaris 94.48 0.00e+00 823.00
IUUC-Cpo-021628 Cavia porcellus 88.28 0.00e+00 802.00
IUUC-Csa-023058 Chlorocebus sabaeus 97.01 0.00e+00 852.00
IUUC-Dre-027659 Danio rerio 41.33 7.00e-80 291.00
IUUC-Dno-029861 Dasypus novemcinctus 94.48 0.00e+00 852.00
IUUC-Dor-030291 Dipodomys ordii 91.49 0.00e+00 833.00
IUUC-Ete-033178 Echinops telfairi 85.09 0.00e+00 728.00
IUUC-Eca-033467 Equus caballus 96.32 0.00e+00 837.00
IUUC-Eeu-034718 Erinaceus europaeus 92.64 0.00e+00 802.00
IUUC-Fca-036324 Felis catus 93.56 0.00e+00 824.00
IUUC-Fal-037537 Ficedula albicollis 71.88 2.00e-178 619.00
IUUC-Gga-040945 Gallus gallus 66.21 3.00e-157 548.00
IUUC-Gac-041897 Gasterosteus aculeatus 40.49 9.00e-74 270.00
IUUC-Ggo-044413 Gorilla gorilla 99.77 0.00e+00 873.00
IUUC-Itr-048633 Ictidomys tridecemlineatus 94.25 0.00e+00 851.00
IUUC-Lch-050677 Latimeria chalumnae 57.47 3.00e-134 471.00
IUUC-Loc-052804 Lepisosteus oculatus 54.47 6.00e-104 371.00
IUUC-Laf-053352 Loxodonta africana 92.69 0.00e+00 733.00
IUUC-Mcc-055704 Macaca mulatta 97.58 0.00e+00 721.00
IUUC-Mga-059603 Meleagris gallopavo 68.41 1.00e-145 509.00
IUUC-Mmr-061175 Microcebus murinus 96.67 3.00e-31 125.00
IUUC-Mdo-063040 Monodelphis domestica 87.04 0.00e+00 638.00
IUUC-Mmu-063587 Mus musculus 90.89 0.00e+00 804.00
IUUC-Mpu-066137 Mustela putorius furo 93.79 0.00e+00 851.00
IUUC-Mlu-068132 Myotis lucifugus 93.33 0.00e+00 819.00
IUUC-Nle-069753 Nomascus leucogenys 98.73 2.00e-177 615.00
IUUC-Opr-071048 Ochotona princeps 78.21 6.00e-129 454.00
IUUC-Ont-072048 Oreochromis niloticus 41.25 1.00e-77 283.00
IUUC-Oan-072845 Ornithorhynchus anatinus 75.74 0.00e+00 635.00
IUUC-Ocu-074564 Oryctolagus cuniculus 71.26 5.00e-172 597.00
IUUC-Ola-087233 Oryzias latipes 41.18 1.00e-74 273.00
IUUC-Oga-088508 Otolemur garnettii 92.18 0.00e+00 836.00
IUUC-Oar-089268 Ovis aries 95.40 0.00e+00 830.00
IUUC-Ptr-091072 Pan troglodytes 99.77 0.00e+00 873.00
IUUC-Pan-092136 Papio anubis 97.24 0.00e+00 846.00
IUUC-Psi-093721 Pelodiscus sinensis 75.74 0.00e+00 662.00
IUUC-Pfo-096731 Poecilia formosa 40.40 2.00e-74 273.00
IUUC-Pab-097737 Pongo abelii 99.31 0.00e+00 868.00
IUUC-Pca-100695 Procavia capensis 91.72 0.00e+00 824.00
IUUC-Pva-103115 Pteropus vampyrus 94.02 0.00e+00 848.00
IUUC-Rno-105648 Rattus norvegicus 89.04 0.00e+00 781.00
IUUC-Sha-107219 Sarcophilus harrisii 88.24 0.00e+00 657.00
IUUC-Sar-112990 Sorex araneus 92.41 0.00e+00 827.00
IUUC-Tgu-117413 Taeniopygia guttata 71.43 1.00e-178 619.00
IUUC-Tru-118484 Takifugu rubripes 41.18 5.00e-73 268.00
IUUC-Tbe-127785 Tupaia belangeri 94.94 0.00e+00 861.00
IUUC-Ttr-128226 Tursiops truncatus 85.98 0.00e+00 766.00
IUUC-Vpa-130406 Vicugna pacos 93.33 0.00e+00 802.00
Created Date 25-Jun-2017

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