iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-055026

Ensembl Protein ID

ENSMMUP00000025241.3

UniProt Accession

F6QQC0; F6QQC0_MACMU

Genbank Protein ID

ENSMMUP00000025241

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

JSUE03040819

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019206.3	ENSMMUT00000026980.3	ENSMMUP00000025241.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.30e-14	52.4	60	117

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++ v +lydy a nd +L++ kG++++v+   +  ++W+ +++  +g++G +P+nFv+++e
   Q: 60   EHFVVALYDYAAMNDRDLQMLKGEKLQVL---KGTGDWWLAKSLVTGREGYVPSNFVARVE 117
           67899************************...999************************97 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDPPPLPP LVVFNHLTPP PPKEHLEEDE 60
HFVVALYDYA AMNDRDLQML KGEKLQVLKG TGDWWLAKSL VTGREGYVPS NFVARVESLE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAGCACTGT GCCCCATTGA GGCCTCTGCC TACATCTACT ATGCTCCACT GCAGTGATCT 60
CCTTATCAGG CCCCTTCCCC AAGCTCCTTA GGCTGAGACC CTCAGAGGAG GATGGAGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	89.90	0.00e+00	908.00
IUUC-Apl-003307	Anas platyrhynchos	76.85	0.00e+00	744.00
IUUC-Aca-004357	Anolis carolinensis	69.51	0.00e+00	676.00
IUUC-Ame-010642	Astyanax mexicanus	71.43	0.00e+00	691.00
IUUC-Bta-012400	Bos taurus	87.55	0.00e+00	895.00
IUUC-Cja-019717	Callithrix jacchus	89.68	0.00e+00	726.00
IUUC-Cfa-021056	Canis familiaris	88.32	0.00e+00	921.00
IUUC-Cpo-021779	Cavia porcellus	86.73	0.00e+00	874.00
IUUC-Csa-023557	Chlorocebus sabaeus	99.41	0.00e+00	988.00
IUUC-Dre-027517	Danio rerio	69.70	0.00e+00	698.00
IUUC-Eca-034218	Equus caballus	89.65	0.00e+00	896.00
IUUC-Eeu-035095	Erinaceus europaeus	68.12	0.00e+00	669.00
IUUC-Fca-036015	Felis catus	87.33	0.00e+00	907.00
IUUC-Fal-036946	Ficedula albicollis	76.85	0.00e+00	740.00
IUUC-Gga-040822	Gallus gallus	75.95	0.00e+00	748.00
IUUC-Ggo-044608	Gorilla gorilla	97.42	0.00e+00	865.00
IUUC-Hsa-046719	Homo sapiens	97.23	0.00e+00	966.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	89.31	0.00e+00	893.00
IUUC-Lch-050114	Latimeria chalumnae	72.10	0.00e+00	698.00
IUUC-Loc-052326	Lepisosteus oculatus	72.17	0.00e+00	712.00
IUUC-Laf-053387	Loxodonta africana	86.73	0.00e+00	899.00
IUUC-Mga-059427	Meleagris gallopavo	75.50	0.00e+00	736.00
IUUC-Mmr-061660	Microcebus murinus	90.30	0.00e+00	906.00
IUUC-Mdo-062318	Monodelphis domestica	75.54	0.00e+00	793.00
IUUC-Mmu-063325	Mus musculus	87.13	0.00e+00	900.00
IUUC-Mpu-066582	Mustela putorius furo	89.48	0.00e+00	904.00
IUUC-Nle-069624	Nomascus leucogenys	96.83	0.00e+00	938.00
IUUC-Opr-070656	Ochotona princeps	82.77	0.00e+00	815.00
IUUC-Ont-072266	Oreochromis niloticus	69.03	0.00e+00	675.00
IUUC-Ocu-073907	Oryctolagus cuniculus	86.53	0.00e+00	877.00
IUUC-Oga-088057	Otolemur garnettii	89.13	0.00e+00	910.00
IUUC-Oar-089332	Ovis aries	82.61	0.00e+00	849.00
IUUC-Ptr-091551	Pan troglodytes	96.30	0.00e+00	922.00
IUUC-Pan-092173	Papio anubis	99.21	0.00e+00	958.00
IUUC-Psi-093895	Pelodiscus sinensis	74.46	0.00e+00	744.00
IUUC-Pfo-096608	Poecilia formosa	69.91	0.00e+00	688.00
IUUC-Pab-097598	Pongo abelii	97.62	0.00e+00	927.00
IUUC-Pva-102135	Pteropus vampyrus	90.48	0.00e+00	885.00
IUUC-Rno-104891	Rattus norvegicus	87.52	0.00e+00	884.00
IUUC-Sha-107192	Sarcophilus harrisii	77.36	0.00e+00	811.00
IUUC-Ssc-115696	Sus scrofa	87.94	0.00e+00	909.00
IUUC-Tgu-117056	Taeniopygia guttata	76.13	0.00e+00	735.00
IUUC-Tru-117621	Takifugu rubripes	67.93	0.00e+00	653.00
IUUC-Tbe-127520	Tupaia belangeri	89.15	0.00e+00	687.00
IUUC-Ttr-128457	Tursiops truncatus	86.96	0.00e+00	902.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence