iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-021069

Ensembl Protein ID

ENSCAFP00000015791.3

UniProt Accession

F1PPM4; F1PPM4_CANLF

Genbank Protein ID

ENSCAFP00000015791

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03016632

Gene Name

AIRE

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000010724.3	ENSCAFT00000017065.3	ENSCAFP00000015791.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.20e-15	57.8	297	341

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC++gge    l++C+ C ++fH aCl+++   + p+ + w C++C 
   Q: 297  DECAVCRDGGE----LICCDGCPRAFHLACLSPP-LHDIPSGT-WRCSSCL 341
           57*********....*******************.*******6.******6 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

RAGGDAGLRR LLRLHRTEIA MAVDCAFPLL HALADHDVVP EDKFQETLRL KEKEGCPQAF 60
HALLSWLLTQ DAAAILDFWR VLFKDYNVER YARLQPILDS FPKDVDLSQP RKGRKPPPGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCCGGTG GGGATGCGGG GCTGCGCCGC CTCCTGAGGC TGCACCGCAC GGAGATCGCC 60
ATGGCTGTGG ACTGCGCCTT CCCGCTGCTG CACGCACTGG CCGACCACGA CGTGGTCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008087--AIRE
IPR004865--HSR_dom
IPR000770--SAND_dom
IPR010919--SAND_dom-like
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51414--HSR
PS50864--SAND
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF03172--HSR
PF00628--PHD
PF01342--SAND

PRINTS

PR01711--AIREGULATOR

SMART

SM00249--PHD
SM00258--SAND

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0042393--F:histone binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0045182--F:translation regulator activity
GO:0008270--F:zinc ion binding
GO:0002509--P:central tolerance induction to self antigen
GO:0032602--P:chemokine production
GO:0006959--P:humoral immune response
GO:0006955--P:immune response
GO:0045060--P:negative thymic T cell selection
GO:0002458--P:peripheral T cell tolerance induction
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000410--P:regulation of thymocyte migration
GO:0097536--P:thymus epithelium morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001612	Ailuropoda melanoleuca	83.04	0.00e+00	732.00
IUUC-Aca-004543	Anolis carolinensis	69.35	3.00e-24	102.00
IUUC-Bta-012988	Bos taurus	78.32	0.00e+00	697.00
IUUC-Bdi-014663	Brachypodium distachyon	59.57	5.00e-13	70.90
IUUC-Cja-019486	Callithrix jacchus	72.16	9.00e-103	366.00
IUUC-Cpo-021649	Cavia porcellus	68.74	1.00e-156	546.00
IUUC-Csa-023960	Chlorocebus sabaeus	77.80	9.00e-180	623.00
IUUC-Dre-028583	Danio rerio	42.22	6.00e-61	228.00
IUUC-Dno-029869	Dasypus novemcinctus	69.04	1.00e-137	483.00
IUUC-Dor-030263	Dipodomys ordii	84.04	1.00e-45	176.00
IUUC-Ete-032778	Echinops telfairi	90.82	6.00e-49	188.00
IUUC-Eca-034328	Equus caballus	78.22	0.00e+00	673.00
IUUC-Fca-035400	Felis catus	81.60	0.00e+00	691.00
IUUC-Fal-036644	Ficedula albicollis	52.21	1.00e-71	264.00
IUUC-Fox-038014	Fusarium oxysporum	40.00	5.00e-09	57.40
IUUC-Fso-038262	Fusarium solani	43.14	5.00e-09	57.40
IUUC-Ggo-045250	Gorilla gorilla	77.24	0.00e+00	645.00
IUUC-Hsa-046603	Homo sapiens	77.24	0.00e+00	645.00
IUUC-Hvu-047073	Hordeum vulgare	56.52	5.00e-13	70.50
IUUC-Itr-048977	Ictidomys tridecemlineatus	72.22	4.00e-167	581.00
IUUC-Lch-050310	Latimeria chalumnae	41.41	2.00e-100	359.00
IUUC-Loc-052508	Lepisosteus oculatus	39.36	1.00e-98	353.00
IUUC-Laf-054028	Loxodonta africana	68.49	5.00e-159	554.00
IUUC-Mcc-054935	Macaca mulatta	76.31	0.00e+00	656.00
IUUC-Mga-059318	Meleagris gallopavo	42.15	2.00e-54	205.00
IUUC-Mmr-061557	Microcebus murinus	63.24	6.00e-136	477.00
IUUC-Mdo-062475	Monodelphis domestica	53.08	2.00e-125	442.00
IUUC-Mmu-063994	Mus musculus	70.81	0.00e+00	689.00
IUUC-Mpu-066347	Mustela putorius furo	83.01	0.00e+00	791.00
IUUC-Mlu-068239	Myotis lucifugus	68.80	3.00e-93	335.00
IUUC-Nle-069544	Nomascus leucogenys	81.25	4.00e-26	111.00
IUUC-Opr-071199	Ochotona princeps	74.80	4.00e-73	268.00
IUUC-Ont-072571	Oreochromis niloticus	31.78	5.00e-38	152.00
IUUC-Oan-073739	Ornithorhynchus anatinus	55.37	4.00e-147	514.00
IUUC-Ogl-077865	Oryza glaberrima	56.52	2.00e-12	68.20
IUUC-Olo-080499	Oryza longistaminata	48.21	2.00e-12	68.60
IUUC-Opu-083209	Oryza punctata	56.52	3.00e-12	68.20
IUUC-Ola-086528	Oryzias latipes	35.69	1.00e-43	171.00
IUUC-Oga-088353	Otolemur garnettii	77.90	0.00e+00	677.00
IUUC-Oar-090065	Ovis aries	77.14	2.00e-151	528.00
IUUC-Ptr-091347	Pan troglodytes	77.99	0.00e+00	631.00
IUUC-Pan-092423	Papio anubis	77.21	0.00e+00	661.00
IUUC-Psi-093798	Pelodiscus sinensis	51.31	2.00e-126	445.00
IUUC-Pfo-096145	Poecilia formosa	65.52	3.00e-20	93.20
IUUC-Pab-098369	Pongo abelii	80.85	1.00e-124	439.00
IUUC-Pca-100537	Procavia capensis	71.56	3.00e-170	591.00
IUUC-Ppe-101215	Prunus persica	60.42	4.00e-14	73.90
IUUC-Pva-102639	Pteropus vampyrus	78.74	0.00e+00	659.00
IUUC-Rno-105285	Rattus norvegicus	71.61	0.00e+00	680.00
IUUC-Sha-107159	Sarcophilus harrisii	50.63	2.00e-124	439.00
IUUC-Sit-110355	Setaria italica	62.50	4.00e-13	71.20
IUUC-Sbi-113930	Sorghum bicolor	37.72	2.00e-13	72.40
IUUC-Ssc-115773	Sus scrofa	79.47	0.00e+00	714.00
IUUC-Tgu-116922	Taeniopygia guttata	50.00	3.00e-71	261.00
IUUC-Tru-118263	Takifugu rubripes	31.76	2.00e-56	213.00
IUUC-Tsy-119270	Tarsius syrichta	70.61	2.00e-92	333.00
IUUC-Tni-120138	Tetraodon nigroviridis	29.76	1.00e-55	210.00
IUUC-Tca-121757	Theobroma cacao	52.83	5.00e-13	70.90
IUUC-Tae-124715	Triticum aestivum	56.52	6.00e-13	70.50
IUUC-Tme-127204	Tuber melanosporum	53.19	2.00e-13	71.60
IUUC-Tbe-128077	Tupaia belangeri	70.49	0.00e+00	642.00
IUUC-Ttr-128781	Tursiops truncatus	82.87	8.00e-79	287.00
IUUC-Xma-133054	Xiphophorus maculatus	30.05	2.00e-52	200.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence