iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091502

UUCD1 version

UUC-PaT-00361

Ensembl Protein ID

ENSPTRP00000016513.3

UniProt Accession

H2QDZ6; H2QDZ6_PANTR

Genbank Protein ID

JAA08428.1; JAA21443.1; JAA28967.1; JAA39822.1

Protein Name

Suppressor of cytokine signaling 3

Genbank Nucleotide ID

AACZ03109948; GABF01000702; GABD01004133; GABE01004917

Gene Name

SOCS3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000009709.3	ENSPTRT00000017822.3	ENSPTRP00000016513.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	100.00	1.00e-111	399.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCGACT TGGACTCCCT GCTCCGCTGC CGCCGCTTCG GCCCCGCACG CAGCCAGCCG 60
CCCGCCGCCC GCCCGGTCCA GCTCCCGCCG CGGCCCCTTG CCGCGGTCCC TCTCCTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

KEGG

ptr:454921

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	96.44	9.00e-108	382.00
IUUC-Apl-003607	Anas platyrhynchos	82.22	8.00e-97	345.00
IUUC-Aca-005063	Anolis carolinensis	82.38	2.00e-103	367.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	7.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	57.39	4.00e-71	260.00
IUUC-Bta-012817	Bos taurus	91.70	2.00e-111	394.00
IUUC-Bra-017963	Brassica rapa	30.00	5.20e-02	32.30
IUUC-Cja-019605	Callithrix jacchus	99.11	2.00e-114	404.00
IUUC-Cfa-021231	Canis familiaris	97.78	3.00e-109	387.00
IUUC-Cpo-022003	Cavia porcellus	91.23	1.00e-107	381.00
IUUC-Csa-023511	Chlorocebus sabaeus	100.00	6.00e-113	399.00
IUUC-Dre-028536	Danio rerio	59.57	8.00e-74	269.00
IUUC-Dno-029003	Dasypus novemcinctus	92.44	4.00e-110	390.00
IUUC-Eca-034205	Equus caballus	83.80	3.00e-68	250.00
IUUC-Fca-036317	Felis catus	95.96	2.00e-108	384.00
IUUC-Gmo-038777	Gadus morhua	63.89	8.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	83.11	6.00e-97	346.00
IUUC-Gac-041837	Gasterosteus aculeatus	55.90	2.00e-65	241.00
IUUC-Ggo-045620	Gorilla gorilla	100.00	6.00e-113	399.00
IUUC-Hsa-046909	Homo sapiens	100.00	6.00e-113	399.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	91.91	6.00e-112	396.00
IUUC-Lch-049510	Latimeria chalumnae	68.12	6.00e-85	306.00
IUUC-Loc-052863	Lepisosteus oculatus	63.04	1.00e-79	288.00
IUUC-Laf-054136	Loxodonta africana	92.54	2.00e-109	387.00
IUUC-Mcc-055383	Macaca mulatta	100.00	6.00e-113	399.00
IUUC-Meu-056153	Macropus eugenii	88.50	2.00e-110	391.00
IUUC-Mmr-061185	Microcebus murinus	95.13	3.00e-107	380.00
IUUC-Mdo-061819	Monodelphis domestica	89.33	1.00e-113	402.00
IUUC-Mmu-064231	Mus musculus	96.89	2.00e-119	421.00
IUUC-Mpu-066691	Mustela putorius furo	98.67	3.00e-109	387.00
IUUC-Mlu-067673	Myotis lucifugus	96.02	3.00e-116	410.00
IUUC-Ont-072406	Oreochromis niloticus	55.02	2.00e-68	251.00
IUUC-Oan-073249	Ornithorhynchus anatinus	74.67	6.00e-94	336.00
IUUC-Ocu-074935	Oryctolagus cuniculus	88.41	5.00e-32	128.00
IUUC-Ola-087373	Oryzias latipes	48.04	3.00e-48	184.00
IUUC-Oga-088041	Otolemur garnettii	92.89	1.00e-109	388.00
IUUC-Oar-089646	Ovis aries	90.39	2.00e-103	368.00
IUUC-Pan-091934	Papio anubis	100.00	6.00e-113	399.00
IUUC-Pfo-096412	Poecilia formosa	42.79	3.00e-48	184.00
IUUC-Pab-098554	Pongo abelii	100.00	6.00e-113	399.00
IUUC-Rno-105874	Rattus norvegicus	96.44	4.00e-119	420.00
IUUC-Sha-107151	Sarcophilus harrisii	87.28	3.00e-110	390.00
IUUC-Ssc-115722	Sus scrofa	88.37	2.00e-65	240.00
IUUC-Tgu-117151	Taeniopygia guttata	84.00	3.00e-97	347.00
IUUC-Tru-118428	Takifugu rubripes	54.15	2.00e-68	251.00
IUUC-Tni-120590	Tetraodon nigroviridis	54.59	3.00e-67	247.00
IUUC-Ttr-129065	Tursiops truncatus	93.01	3.00e-111	393.00
IUUC-Xtr-132167	Xenopus tropicalis	65.78	8.00e-82	295.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence