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Tag Content
UUCD2 ID IUUC-Pab-097578
UUCD1 version UUC-PoA-00912
Ensembl Protein ID ENSPPYP00000020352.1
UniProt Accession Q5R4G6; CUL1_PONAB
Genbank Protein ID CAH93350.1
Protein Name Cullin-1
Genbank Nucleotide ID CR861282
Gene Name CUL1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000018146.2 ENSPPYT00000021153.1 ENSPPYP00000020352.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/Cullin 3.20e-226 752.9 24 660
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...........................vgaklYkklkevleefikqvkkkveesed 62
    lr++++++++++s+ k++y+elyt+vyn+c+s vg +lYk+lke+l+++++++ k+ e+ +d
   Q: 24 LRAGIQQVYTRQSMaKSRYMELYTHVYNYCTSVhqsnqargagvppskskkgqtpggaqfVGLELYKRLKEFLKNYLTNLLKDGEDLMD 112
    7899***************************9999****************************************************** PP
   S: 63 eqlLktynreWekfreqlkvlrkifayldrtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrll 146
    e++Lk+y+++We++r ++kvl+ i+ayl+r++v++ +k ++e+++Lal +wr++++++++k++++++lklie+eR+ge++++rl+
   Q: 113 ESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRecdegRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLI 201
    ***********************************999999999********************************************* PP
   S: 147 sgvveslveLslnk.........laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlev 226
    sgvv+s+veL+ln+ l++ykesFE++fl t++fy++es+eflq+n v+eY+kk+earl ee++r++ yl+est+++L+++
   Q: 202 SGVVQSYVELGLNEddafakgptLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARK 290
    ***************************************************************************************** PP
   S: 227 vekeliakhlesllaelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqk 313
    +e++li+khle +++e+++ll+ +k+edl+rmy+L+sr+++gl el k le+hi++qg+aa++ e++ +dpk+yV+++l++++k++
   Q: 291 CEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEkcGEAALNDPKMYVQTVLDVHKKYNA 379
    ***************************************************************9999999******************* PP
   S: 314 lvseaFnndakFlkaldkafetfvnknsvlka....akspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkk 398
    lv++aFnnda F+ aldka+ +f+n+n+v+k+ +kspEllAry+D+lL+kssk+++e+ele++l++v++vfkyi++kdvF+k+Y+k
   Q: 380 LVMSAFNNDAGFVAALDKACGRFINNNAVTKMaqssSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAK 468
    ***************************************************************************************** PP
   S: 399 hLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsL 487
    +LakRL++++sas++aE+s+i+kLk++cg+e+tskL+rMfqd+ vS+dln+qFk++ +n+ e ++++s++vLs+g+Wp++++ ++L
   Q: 469 MLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNS-EPLDLDFSIQVLSSGSWPFQQSCT-FAL 555
    ******************************************************777776.99******************7755.*** PP
   S: 488 PaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLv 576
    P+ele+++++f++fY ++hsgRkL+W+++l+++el ++++k++y+lq+stfQma+LL++n++++++v++l+++t+++++ L ++lq L+
   Q: 556 PSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILL 644
    ***************************************************************************************** PP
   S: 577 sskkqvlkkepeskeiee 594
    +sk vl e+e+++++e
   Q: 645 KSKLLVL--EDENANVDE 660
    **95555..555555443 PP
   

Organism Pongo abelii
Functional Description
(View)

Functional Description



     Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Interacts with COPS9.
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Interacts with COPS9.
Protein Sequence
(Fasta)
MSSTRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN 60
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Pab-097578|E3,Cullin|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTCGCCGGG GCCCAGGCCC AGGGACCAGG CGGAGGCGTC GCGGAAGCCT TTGGGGCACC 60
ACAGAGATGC GGGTGAGTGT CGGCAGCCGC CGGGGCCGAG AGGAGGTGGC GGCGGCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Pab-097578|E3,Cullin|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0488--Methylation
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0009887--P:animal organ morphogenesis
GO:0006915--P:apoptotic process
GO:0008283--P:cell proliferation
GO:0006513--P:protein monoubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG pon:100173991
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002277 Ailuropoda melanoleuca 99.61 0.00e+00 1574.00
IUUC-Apl-003503 Anas platyrhynchos 99.18 0.00e+00 1269.00
IUUC-Aca-005030 Anolis carolinensis 87.36 0.00e+00 1226.00
IUUC-Ago-007977 Ashbya gossypii 32.76 6.00e-119 421.00
IUUC-Acl-008190 Aspergillus clavatus 49.09 0.00e+00 669.00
IUUC-Afl-008542 Aspergillus flavus 49.92 3.00e-157 548.00
IUUC-Afu-009007 Aspergillus fumigatus 48.75 0.00e+00 651.00
IUUC-Ani-009290 Aspergillus nidulans 46.89 0.00e+00 687.00
IUUC-Ang-009600 Aspergillus niger 48.40 0.00e+00 663.00
IUUC-Aor-009978 Aspergillus oryzae 47.61 3.00e-174 605.00
IUUC-Ate-010584 Aspergillus terreus 48.35 0.00e+00 687.00
IUUC-Ame-011861 Astyanax mexicanus 95.32 0.00e+00 1461.00
IUUC-Bgr-012209 Blumeria graminis 48.21 0.00e+00 652.00
IUUC-Bta-012878 Bos taurus 99.74 0.00e+00 1578.00
IUUC-Bci-013941 Botrytis cinerea 48.12 0.00e+00 714.00
IUUC-Cel-018294 Caenorhabditis elegans 46.54 0.00e+00 695.00
IUUC-Cja-018965 Callithrix jacchus 95.11 0.00e+00 1495.00
IUUC-Cfa-020671 Canis familiaris 99.74 0.00e+00 1578.00
IUUC-Cpo-021762 Cavia porcellus 99.74 0.00e+00 1579.00
IUUC-Csa-023873 Chlorocebus sabaeus 100.00 0.00e+00 1582.00
IUUC-Cho-024978 Choloepus hoffmanni 100.00 2.00e-116 412.00
IUUC-Cin-025547 Ciona intestinalis 72.94 0.00e+00 1121.00
IUUC-Csv-026083 Ciona savignyi 71.72 0.00e+00 1163.00
IUUC-Cgl-026452 Colletotrichum gloeosporioides 48.42 0.00e+00 684.00
IUUC-Cne-026919 Cryptococcus neoformans 42.93 0.00e+00 629.00
IUUC-Dre-027875 Danio rerio 95.75 0.00e+00 1478.00
IUUC-Dno-028931 Dasypus novemcinctus 99.61 0.00e+00 1572.00
IUUC-Dor-030846 Dipodomys ordii 99.61 0.00e+00 1016.00
IUUC-Dse-031472 Dothistroma septosporum 45.58 1.00e-178 620.00
IUUC-Dme-031793 Drosophila melanogaster 62.77 0.00e+00 944.00
IUUC-Ete-033112 Echinops telfairi 89.50 5.00e-169 587.00
IUUC-Eca-034309 Equus caballus 99.74 0.00e+00 1578.00
IUUC-Eeu-034450 Erinaceus europaeus 69.36 0.00e+00 716.00
IUUC-Fca-036330 Felis catus 96.29 0.00e+00 1513.00
IUUC-Fal-036899 Ficedula albicollis 99.85 0.00e+00 1377.00
IUUC-Fox-037705 Fusarium oxysporum 48.94 0.00e+00 653.00
IUUC-Fso-038367 Fusarium solani 49.36 0.00e+00 674.00
IUUC-Gmo-038708 Gadus morhua 94.23 0.00e+00 1464.00
IUUC-Ggr-039917 Gaeumannomyces graminis 47.74 0.00e+00 682.00
IUUC-Gga-041038 Gallus gallus 99.87 0.00e+00 1580.00
IUUC-Gac-041820 Gasterosteus aculeatus 94.62 0.00e+00 1514.00
IUUC-Ggo-045154 Gorilla gorilla 83.04 0.00e+00 1113.00
IUUC-Hsa-046034 Homo sapiens 100.00 0.00e+00 1582.00
IUUC-Itr-048285 Ictidomys tridecemlineatus 99.74 0.00e+00 1578.00
IUUC-Kpa-049231 Komagataella pastoris 38.61 9.00e-135 474.00
IUUC-Lch-049673 Latimeria chalumnae 98.45 0.00e+00 1558.00
IUUC-Loc-052490 Lepisosteus oculatus 97.55 0.00e+00 1519.00
IUUC-Lma-053191 Leptosphaeria maculans 48.51 0.00e+00 668.00
IUUC-Laf-054582 Loxodonta africana 99.61 0.00e+00 1577.00
IUUC-Mcc-055162 Macaca mulatta 99.10 0.00e+00 1563.00
IUUC-Meu-055904 Macropus eugenii 87.46 7.00e-160 557.00
IUUC-Mor-057035 Magnaporthe oryzae 47.14 0.00e+00 655.00
IUUC-Mpo-057555 Magnaporthe poae 47.74 0.00e+00 681.00
IUUC-Mla-059021 Melampsora laricipopulina 48.19 0.00e+00 659.00
IUUC-Mga-060078 Meleagris gallopavo 99.87 0.00e+00 1580.00
IUUC-Mvi-060519 Microbotryum violaceum 47.61 0.00e+00 684.00
IUUC-Mmr-061312 Microcebus murinus 100.00 0.00e+00 1582.00
IUUC-Mdo-062867 Monodelphis domestica 99.36 0.00e+00 1572.00
IUUC-Mmu-063336 Mus musculus 99.87 0.00e+00 1580.00
IUUC-Mpu-066400 Mustela putorius furo 99.70 0.00e+00 1376.00
IUUC-Mlu-067800 Myotis lucifugus 99.49 0.00e+00 1571.00
IUUC-Nfi-068384 Neosartorya fischeri 51.01 0.00e+00 652.00
IUUC-Ncr-068965 Neurospora crassa 48.10 0.00e+00 683.00
IUUC-Nle-069729 Nomascus leucogenys 100.00 0.00e+00 1582.00
IUUC-Ont-071729 Oreochromis niloticus 95.49 0.00e+00 1498.00
IUUC-Oan-073309 Ornithorhynchus anatinus 99.74 0.00e+00 1580.00
IUUC-Ocu-074661 Oryctolagus cuniculus 99.48 0.00e+00 1530.00
IUUC-Ola-087422 Oryzias latipes 94.09 0.00e+00 1494.00
IUUC-Oga-088130 Otolemur garnettii 100.00 0.00e+00 1582.00
IUUC-Oar-089510 Ovis aries 98.15 0.00e+00 1507.00
IUUC-Ptr-090665 Pan troglodytes 100.00 0.00e+00 1582.00
IUUC-Pan-092218 Papio anubis 100.00 0.00e+00 1582.00
IUUC-Psi-093175 Pelodiscus sinensis 99.74 0.00e+00 1579.00
IUUC-Pma-094502 Petromyzon marinus 90.45 0.00e+00 1432.00
IUUC-Pno-095067 Phaeosphaeria nodorum 47.97 0.00e+00 698.00
IUUC-Pfo-096705 Poecilia formosa 95.36 0.00e+00 1533.00
IUUC-Pca-100242 Procavia capensis 85.80 0.00e+00 1144.00
IUUC-Pva-102155 Pteropus vampyrus 87.89 0.00e+00 1350.00
IUUC-Pgr-103297 Puccinia graminis 45.92 0.00e+00 669.00
IUUC-Ptt-103706 Puccinia triticina 45.09 7.00e-94 339.00
IUUC-Pte-104257 Pyrenophora teres 48.29 0.00e+00 695.00
IUUC-Pyt-104795 Pyrenophora triticirepentis 48.84 0.00e+00 695.00
IUUC-Rno-105939 Rattus norvegicus 99.87 0.00e+00 1580.00
IUUC-Sce-106293 Saccharomyces cerevisiae 31.80 9.00e-117 414.00
IUUC-Sha-106949 Sarcophilus harrisii 99.74 0.00e+00 1579.00
IUUC-Sja-107737 Schizosaccharomyces japonicus 42.78 8.00e-158 550.00
IUUC-Spo-108280 Schizosaccharomyces pombe 41.91 3.00e-163 568.00
IUUC-Sre-114984 Sporisorium reilianum 45.96 0.00e+00 632.00
IUUC-Ssc-115829 Sus scrofa 99.10 0.00e+00 1561.00
IUUC-Tgu-116950 Taeniopygia guttata 99.87 0.00e+00 1580.00
IUUC-Tru-118558 Takifugu rubripes 94.97 0.00e+00 1507.00
IUUC-Tsy-118934 Tarsius syrichta 98.06 0.00e+00 738.00
IUUC-Tni-120460 Tetraodon nigroviridis 94.85 0.00e+00 1513.00
IUUC-Tre-122223 Trichoderma reesei 49.65 0.00e+00 638.00
IUUC-Tvi-122539 Trichoderma virens 44.59 5.00e-173 601.00
IUUC-Tme-126926 Tuber melanosporum 47.69 0.00e+00 675.00
IUUC-Tbe-127369 Tupaia belangeri 97.96 0.00e+00 652.00
IUUC-Ttr-129022 Tursiops truncatus 94.15 0.00e+00 1139.00
IUUC-Uma-129341 Ustilago maydis 46.16 2.00e-173 602.00
IUUC-Vda-129857 Verticillium dahliae 47.27 0.00e+00 647.00
IUUC-Vpa-130166 Vicugna pacos 93.36 0.00e+00 1222.00
IUUC-Xtr-131818 Xenopus tropicalis 98.97 0.00e+00 1560.00
IUUC-Xma-134206 Xiphophorus maculatus 95.49 0.00e+00 1494.00
IUUC-Yli-134486 Yarrowia lipolytica 39.92 2.00e-155 542.00
Created Date 25-Jun-2017

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